Trans ε-viniferin is an amyloid-β disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer's disease

Vion, Elodie; Page, Guylène; Bourdeaud, Eric; Pocard, Marc; Guillard, Jérôme; Bilan, Agnès Rioux

doi:10.1016/j.mcn.2017.12.003

Cited by 51 publications

(31 citation statements)

References 42 publications

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“…AD is accepted as the most common form of dementia and WHO estimates that there are about 50 million people having dementia worldwide. Vion et al, demonstrated that trans-ϵ-viniferin could induce the disaggregation of the amyloid ß (Aß) peptide which accumulates during the progression of AD and also prevent neuroinflammation in a murine model [ 163 ]. Trans-ϵ-viniferin has been also shown to inhibit the intestinal calcium activated chloride channel which added a new pharmacological potential role of trans-ϵ-viniferin as an antisecretory therapy for rotaviral diarrhea [ 164 ].…”

Section: Therapeutic Importance Of Some Naturally Occurring Sirtuimentioning

confidence: 99%

Natural Products as Modulators of Sirtuins

2020

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Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developments and progress in technology. Natural compounds were shown to bear an inherent ability to bind to biomacromolecules and cover an unparalleled chemical space in comparison to most libraries used for high-throughput screening. Thus, natural products hold a great potential for the drug discovery of new scaffolds for therapeutic targets such as sirtuins. Sirtuins are Class III histone deacetylases that have been linked to many diseases such as Parkinson`s disease, Alzheimer’s disease, type II diabetes, and cancer linked to aging. In this review, we examine the revitalization of interest in natural products for drug discovery and discuss natural product modulators of sirtuins that could serve as a starting point for the development of isoform selective and highly potent drug-like compounds, as well as the potential application of naturally occurring sirtuin inhibitors in human health and those in clinical trials.

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Section: Therapeutic Importance Of Some Naturally Occurring Sirtuimentioning

confidence: 99%

Natural Products as Modulators of Sirtuins

2020

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“…Currently, the drugs available for treating AD are not completely effective and do not alter the disease progression 13,22,23 . It is, therefore, critical that new therapies aimed to prevent and manage this chronic and debilitating disease be developed 24 .…”

Section: Alzheimer's Disease: Clinical and Pathophysiological Aspectsmentioning

confidence: 99%

“…Polyphenols are natural compounds derived from plants, fruits and vegetables, whose biological properties have demonstrated several beneficial effects, such as antioxidant and anti-inflammatory activities 23 .…”

Section: Resveratrolmentioning

confidence: 99%

“…Resveratrol is a non-flavonoid polyphenol 8 part of the stilbene family 23 , which can be found in grape skin and seeds, blackberries, peanuts, and vegetables 25 . Red wine is therefore also a good source of resveratrol, to which the potential beneficial health effects of this beverage has been attributed 26 .…”

Section: Resveratrolmentioning

confidence: 99%

“…Treatment with only either antioxidants or anti-inflammatory drugs has been shown ineffective in preventing AD. Therefore, the development of multi-target drugs is an alternative approach 23 .…”

Section: Perspectivesmentioning

confidence: 99%

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Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential

Sousa

Santana

Magalhães

2020

Arq. Neuro-Psiquiatr.

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ABSTRACT Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible loss of cognitive function. The presence of senile plaques is one of the pathological markers of the disease and is associated with the onset of neuroinflammatory mechanisms. The exact pathophysiology of AD has not been completely understood, and there are no curative therapies yet. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol that is noted for its antioxidant and anti-inflammatory properties. Objective: To review the role of resveratrol in the pathophysiological aspects of AD. Methods: This study carried out a literature review using PubMed/Medline, Virtual Health Library (VHL), Web of Sciences, SCOPUS and the Cochrane Library databases. Original research articles, describing both in vitro and in vivo experiments, published between 2008 and 2018, were included. Results: We identified 667 articles, of which 619 were excluded because they were repeated or did not follow the inclusion criteria. The present study includes the remaining 48 articles. Discussion: Resveratrol demonstrates beneficial and protective effects in AD models and seems to provide a promising therapeutic alternative. Conclusion: Although resveratrol appears to mitigate some pathophysiological aspects of AD, further studies are needed to prove the safety and efficacy of this compound in humans.

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