Transabdominal amnioinfusion: An evaluation of its adverse events

Nagai, Ryuhei; Takahashi, Yuichiro; Iwagaki, Shigenori; Chiaki, Rika; Asai, Kazuhiko; Koike, Masako; Katsura, Daisuke; Yasumi, Shunsuke; Kawabata, Ichiro

doi:10.1016/j.ejogrb.2022.01.032

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Oligohydramnios/anhydramnios can make both amniocentesis and morphological evaluation via ultrasound more difficult. These cases highlight the benefit of using amnioinfusion as a meaningful technique that facilitates sampling of amniotic fluid for genetic diagnosis 5 …”

Section: Discussionmentioning

confidence: 99%

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Prenatal diagnosis of autosomal recessive renal tubular dysgenesis caused by variants in the ACE gene: Two fetuses with anhydramnios

Nguyen Thi,

Nguyen Duy,

Luong Thi Lan

et al. 2023

Prenatal Diagnosis

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IntroductionAutosomal recessive renal tubular dysgenesis (ARRTD) is a rare genetic disorder with a very high mortality rate. The typical symptoms of the disease during pregnancy are oligohydramnios, anhydramnios, and nearly all affected fetuses die after birth or have a stillbirth in late gestation, which can adversely increase maternal risks.MethodsOligohydramnios/anhydramnios can make both amniocentesis for diagnostic testing and morphological evaluation via ultrasound more difficult. In cases of oligohydramnios/anhydramnios suspicious for urinary tract anomalies, amnioinfusion is a meaningful technique that facilitates sampling of amniotic fluid for genetic diagnosis.ResultsWe report two cases of fetuses with anhydramnios and invisible urinary bladder. Clinical exome sequencing from amniotic fluid revealed a biparentally inherited homozygous pathogenic nonsense ACE variant c.2503G 〉 T [p.Glu853Ter] in proband 1 and a biparentally inherited homozygous pathogenic nonsense ACE variant c.2992C 〉 T [p.Gln998Ter] in proband 2. The prognosis was poor and the patients elected to terminate the pregnancies. Additional post‐mortem histopathological examination from the renal tissue of the second fetus showed renal tubular hypoplasia.ConclusionTo our knowledge for the first time, we describe the prenatal diagnosis of ARRTD in Vietnam, and highlight the benefit of detecting ACE variants associated with ARRTD in fetuses with oligohydramnios/anhydramnios through amnioinfusion and amniocentesis, which improves genotype‐phenotype correlations and provides valuable information for reproductive counseling.

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Section: Discussionmentioning

confidence: 99%

“…These cases highlight the benefit of using amnioinfusion as a meaningful technique that facilitates sampling of amniotic fluid for genetic diagnosis. 5 Amniotic fluid testing in 2 probands revealed homozygous nonsense variants in the ACE gene, which were classified as…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of autosomal recessive renal tubular dysgenesis caused by variants in the ACE gene: Two fetuses with anhydramnios

Nguyen Thi,

Nguyen Duy,

Luong Thi Lan

et al. 2023

Prenatal Diagnosis

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“…Uma pesquisa realizada em 2013 pelo Sistema de Informação de Nascidos Vivos (SINASC), mostra que de 100% dos nascidos vivos, 11% são gestantes com faixa etária igual ou superior a 35 anos. Tratando-se de um o apoio e cuidado de alguém mais próximo, como um filho (9,10) .…”

Section: Questões Sociais Da Concepção Tardiaunclassified

Técnicas De Reprodução Assistida Utilizadas Em Mulheres Acima De 50 Anos: Desafios, Riscos E Benefícios

Do Carmo Siqueira,

Duarte Mendes,

Alves Geishofer

et al. 2023

RECIMA21

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Atualmente, mais mulheres vêm optando por uma gravidez “tardia”, devido às responsabilidades pessoais, como estudos, trabalho e outras questões. Dessa forma, a procura por técnicas de reprodução tem aumentado significativamente, o que ainda não é bem aceito em nossa sociedade, ocasionando uma batalha psicológica e até fisiológica para o casal. Durante o envelhecimento, o corpo feminino diminui sua capacidade reprodutiva, tornando, assim, mais difícil uma gravidez natural. Por isso, existem técnicas abordadas em mulheres com idade superior a 50 anos, que representam um menor risco para a mãe e para o feto. Tratando-se de uma gravidez tardia, é extremamente importante que haja o acompanhamento médico para que a saúde física e psicológica do casal seja preservada. A Fertilização In Vitro (FIV), Transferência de embrião congelado (TEC) e Injeção Intracitoplasmática de Espermatozoides (ICSI) são as três técnicas com maior taxa de sucesso, tendo como maior fator de intercorrência a idade da mulher. Embora ainda existam riscos à saúde da mãe e do feto, com os avanços na área da reprodução assistida, é possível tornar esse sonho realidade, facilitando a vida de casais que não vivenciaram uma gravidez antes de alcançarem seus objetivos pessoais e profissionais. Nesta revisão, abordamos a taxa de sucesso de algumas técnicas de reprodução assistida em mulheres acima dos 50 anos de idade, dando ênfase àquelas com maior probabilidade de sucesso, tendo em vista que determinados procedimentos possuem uma idade máxima para sua realização.

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Amnioinfusion compared with expectant management in oligohydramnios with intact amnions in the second and early third trimesters

Yang,

Yao,

Yin

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionTreatment of oligohydramnios in the mid‐trimester is challenging, because of the high incidence of adverse perinatal outcomes mainly due to bronchopulmonary dysplasia. Antenatal amnioinfusion has been proposed as a possible treatment for oligohydramnios with intact amnions, but there are few relevant studies. This study aimed to evaluate the effectiveness of transabdominal amnioinfusion in the management of oligohydramnios without fetal lethal malformations in the second and early third trimesters.Material and MethodsIt is a historical cohort study. A total of 79 patients diagnosed with oligohydramnios at 18–32 weeks gestation were enrolled. In the amnioinfusion group (n = 39), patients received transabdominal amnioinfusion with the assistance of real‐time ultrasound guidance. In the expectant group (n = 41), patients were treated with 3000 mL of intravenous isotonic fluids daily. The perioperative complications and perinatal outcomes were analyzed.ResultsCompared with the expectant group, the delivery latency was significantly prolonged, and the rate of cesarean delivery was significantly reduced in the amnioinfusion group (p < 0.05). Although the rate of intrauterine fetal death was significantly reduced, the incidence of spontaneous miscarriage, premature rupture of membranes (PROMs), and threatened preterm labor were significantly higher in the amnioinfusion group than in the expectant group (p < 0.05). There was no significant difference in terms of perinatal mortality (28.9% vs. 41.4%, p > 0.05). Multivariate logistic regression revealed that amnioinfusion (odds ratio [OR] 0.162, 95% confidence interval [CI] 0.04–0.61, p = 0.008) and gestational age at diagnosis (OR 0.185, 95% CI 0.04–0.73, p = 0.016) were independently associated with neonatal adverse outcomes. Further subgrouping showed that amnioinfusion significantly reduced the frequency of bronchopulmonary hypoplasia for patients ≤26 weeks (26.7% vs. 75.0%, p = 0.021). The rates of other neonatal complications were similar in both groups.ConclusionsAmnioinfusion has no significant effect on improving the perinatal mortality of oligohydramnios in the second and early third trimesters. It may lead to a relatively high rate of PROM and spontaneous abortion. However, amnioinfusion may significantly improve the latency period, the rate of cesarean delivery, and neonatal outcomes of oligohydramnios, especially for women ≤26 weeks with high risk of neonatal bronchopulmonary hypoplasia.

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Transabdominal amnioinfusion: An evaluation of its adverse events

Cited by 4 publications

References 15 publications

Prenatal diagnosis of autosomal recessive renal tubular dysgenesis caused by variants in the ACE gene: Two fetuses with anhydramnios

Prenatal diagnosis of autosomal recessive renal tubular dysgenesis caused by variants in the ACE gene: Two fetuses with anhydramnios

Técnicas De Reprodução Assistida Utilizadas Em Mulheres Acima De 50 Anos: Desafios, Riscos E Benefícios

Amnioinfusion compared with expectant management in oligohydramnios with intact amnions in the second and early third trimesters

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