Transabdominal ultrasonography in preoperative staging of gastric cancer

Liao, Shengri; Dai, Ying; Huo, Ling; Yan, Kun; Zhang, Lin; Zhang, Hui; Gao, Wen; Chen, Minhua

doi:10.3748/wjg.v10.i23.3399

Cited by 40 publications

(35 citation statements)

References 35 publications

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“…These results indicated that gastric cancers that were detected using US were at a more advanced stage compared with those that were not detectable using US. The advancement of gastric cancer is represented with T staging (23), which can be evaluated using transabdominal US with patients drinking water prior to the scan, or using endoscopic US (24,25). In the current study, it was difficult to evaluate pT staging using US as the patients did not consume water prior to screening, and thus pT staging was evaluated subsequent to surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Detection of gastric cancer using transabdominal ultrasonography is associated with tumor diameter and depth of invasion

Tomizawa

Shinozaki

Fugo

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Gastric cancer is occasionally diagnosed using transabdominal ultrasonography (US) during screening or investigation of patients with abdominal symptoms. Therefore, the present study analyzed the association of the tumor diameter, pathological T (pT) staging and depth of invasion with the detection of gastric cancer using US. Patient records were analyzed retrospectively and 13 patients were enrolled, who underwent US screening prior to endoscopic mucosal resection, endoscopic submucosal dissection or surgery. In total, 5 patients were diagnosed with gastric cancer using US (positive detection group), while US was unable to detect the gastric cancer in 8 patients (negative detection group). The tumor diameter and depth of invasion were determined by pathologists. One-way analysis of variance or the χ 2 test was performed. Wall thickness in gastric cancer cases ranged between 7 and 20 mm (mean, 12.2±5.9 mm), as measured using abdominal US. The hemoglobin level was significantly lower in the positive detection patients compared with the negative detection patients (P=0.0455). In addition, the diameters of the gastric wall in the negative and positive detection patients were 24.5±16.4 and 54.4±26.2 mm, respectively (P=0.0266). These results indicate that gastric cancer in the positive detection patients were at a more advanced-stage compared with that in the negative detection patients. Furthermore, gastric cancer with a stage over pT2 was diagnosed using abdominal US (P=0.0242), whereas stage pT1a gastric cancer was not detected by abdominal US. Gastric tumors invading deeper than the submucosa were diagnosed using US (P=0.0242). However, the gastric cancer cases limited to the mucosa remained undetected. In conclusion, the detection of gastric cancer correlated well with the tumor diameter, pT staging and depth of invasion.

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Section: Discussionmentioning

confidence: 99%

Detection of gastric cancer using transabdominal ultrasonography is associated with tumor diameter and depth of invasion

Tomizawa

Shinozaki

Fugo

et al. 2015

Experimental and Therapeutic Medicine

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“…• The sensitivity and specifi city of AUS for the detection of LN metastasis varied between 12.2% and [33] 2004 − − − − − + − + + + − − − 2 2 31 Lee et al [42] 2001 − − − + + + − + + + + + + 4 5 69 Düx et al [53] 1997 + − + + − + − + + − + + + 5 4 69 Kim et al [54] 1997 − − + − + + − − + + − + + 3 4 54 Stell et al [57] 1996 − − − − + − − + + + + + + 2 5 54 EUS Lok et al [17] 2008 − − − − + − − − + + + − + 1 4 38 Bentrem et al [19] 2007 + − − + + + − + + − + + + 5 4 69 Tan et al [20] 2007 − − + + + + − + + + − − − 5 2 54 Arocena et al [24] 2006 + − − − + + − − + + − + + 3 4 54 Ganpathi et al [25] 2006 − − − − + + − + + + + − + 3 4 54 Tsendsuren et al [26] 2006 − − − + + + − + + + − − − 4 2 46 Ang et al [27] 2006 + − − − + + − − + − − + − 3 2 38 Potrc et al [29] 2006 + + − + + + − + + − − + + 6 3 69 Polkowski et al [34] 2004 + − − − + + − + + + + + + 4 5 69 Bhandari et al [35] 2004 + − − − + + − + + + − − + 4 3 54 Javaid et al [36] 2004 − − − + + + − + + + − + − 4 3 54 Habermann et al [37] 2004 + − − + + + − + + + + − + 5 4 69 Xi et al [40] 2003 − − − + + + − + + + − + − 4 3 54 Chen et al [41] 2002 − − + + + + − + + + + + + 5 5 77 Willis et al [43] 2000 + − − + + + − + + + + + − 5 4 69 Tseng et al [44] 2000 − − − + + + − + + + − + + 4 4 62 Mancino et al [46] 2000 − − − + + + − + + + − − − 4 2 46 Akahoshi et al [48] 1998 + − − − + + − + + + + + − 4 4 62 Hunerbein et al [49] 1998 + − − − + + − + + − − − + 4 2 46 Wang et al [50] 1998 + − − + + + − + + + − + − 5 3 62 Hamada et al [52] 1997 − − − + + + − + + + − − − 4 2 46 Hunerbein et al [55] 1996 + − − − − + − + + − + + − 3 3 46 François et al [56] 1996 + − − − + + − + + + − + − 4 3 54 Perng et al [58] 1996 + − − + + − − − + + − + − 3 3 46 Smith et al [60] 1993 − − − + + + − + + − − − + 4 2 46 Ziegler et al [61] 1993...…”

Section: Staging Performanceunclassified

Imaging in assessing lymph node status in gastric cancer

2009

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“…We included only 2 studies that reported pre-operative T staging values (Appendix 1 of the electronic supplementary material), one of which had fair agreement (j, 95% confidence interval [CI]: 0.40, 0.20-0.60) and another with substantial agreement (0.66, 0.55-0.77). This variation may be explained by the difficulty in staging tumors found in the gastric fundus and greater curvature [7,8,42,43], as well as the highly subjective nature of AUS staging and thus its strong operator dependence [42,43].…”

Section: Evaluation Of T Stagingmentioning

confidence: 99%

“…Electronic literature searches were conducted using Medline and Embase from January 1, 1998 [42,43]. b Adapted from [28,53].…”

Section: Data Sourcesmentioning

confidence: 99%

How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis

et al. 2011

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Background Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning. Methods Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed. Results For pre-operative T staging MRI scans had better performance accuracy than CT and AUS; CT scanners using C4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with \4 detectors and axial images only. For pre-operative N staging PET had the lowest sensitivity, but the highest specificity among modalities; CT performance did not significantly differ by detector number or addition of MPR images. For pre-operative M staging performance did not significantly differ by modality, detector number, or MPR images. Conclusions The agreement between pre-operative TNM staging by imaging scans and post-operative staging by pathology is not perfect and may affect treatment decisions. Operator dependence and heterogeneity of data may Electronic supplementary material The online version of this article

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Transabdominal ultrasonography in preoperative staging of gastric cancer

Abstract: Transabdominal US is useful for preoperative staging in gastric cancer, although it is difficult to differentiate benign from malignant lymph nodes.

Cited by 40 publications

References 35 publications

Detection of gastric cancer using transabdominal ultrasonography is associated with tumor diameter and depth of invasion

Detection of gastric cancer using transabdominal ultrasonography is associated with tumor diameter and depth of invasion

Imaging in assessing lymph node status in gastric cancer

How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis

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