Transactivation of Receptor Tyrosine Kinases by Dopamine Receptors

Kruk, Jeff S.; Kouchmeshky, Azita; Grimberg, Nicholas; Rezkella, Marina; Beazely, Michael A.

doi:10.1007/978-1-4939-2196-6_12

Cited by 1 publication

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“…Growth factor receptors such as the PDGFb receptor can be activated directly by their endogenous ligand or be transactivated by signals initiated through other receptors in the absence of PDGF ligand [82,83] . Classic transactivation of growth factor receptors occurs within minutes after activation of GPCRs.…”

Section: Neuroprotective Effects Of Pdgf Receptor Transactivationmentioning

confidence: 99%

Neuroprotective effects of direct activation and transactivation of PDGFβ receptors

Vasefi¹,

Beazely²

2020

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Platelet-derived growth factor (PDGF) receptors are expressed throughout the body, including the central nervous system (CNS). Although the physiological role of PDGF receptors in the developed CNS is not fully characterized, PDGF signaling appears to provide neuroprotective effects against several neuronal insults. One of the bestcharacterized neuroprotective effects of PDGF type-b receptors is against human immunodeficiency virus (HIV) protein-induced neurotoxicity, with potential physiological relevance to HAD. PDGFb receptors are also neuroprotective against glutamate excitotoxicity, which is associated with both stroke and neurodegenerative diseases, including Alzheimer's disease. The neuroprotective effects of PDGFb receptors occur both via direct activation by ligand (PDGF-BB), as well as by PDGFb receptors activated downstream of G protein-coupled receptor signaling. In addition to the involvement of PDGF signaling in various pathologies and potential therapies, there is also an emerging body of evidence that PDGF may serve as a biomarker for neurological or psychiatric diseases.

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Section: Neuroprotective Effects Of Pdgf Receptor Transactivationmentioning

confidence: 99%