This study investigates the effects of project network characteristics (i.e., network density and centrality) and transactive memory systems on project performance. Based on 361 valid questionnaires from megaproject teams, a structural equation modeling (SEM) approach is used for data analysis. The findings discover that high network density is positively associated with specialization, credibility, and project performance, without a significant link with coordination. Meanwhile, a high degree of network centrality negatively affects three dimensions of transactive memory systems, as well as project performance. Regarding the mediating role of transactive memory systems dimensions, specialization and credibility serve as the dominant mediating effects. Interestingly, the interactive relationships among transactive memory systems dimensions are empirically examined. These findings provide a network perspective to integrate and utilize organizational knowledge, thus improving organizational flexibility and resilience.