Transamniotic fetal feeding II. A model of intrauterine growth retardation using the relationship of “Natural runting” to uterine position

Flake, Alan W.; Villa, Robin L.; Adzick, N. Scott; Harrison, Michael R.

doi:10.1016/s0022-3468(87)80643-7

Cited by 28 publications

(24 citation statements)

References 15 publications

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“…The control group reflected previous results with a IUGR to Fav ratio of 0.81. 3 EGF infusion normalized IUGR weights with EGF-Fav versus EGF-IUGR showing no significant differences (47.7 Ϯ 5.8 g v. 44.4 Ϯ 5.9 g; P ϭ .5; weight ratio 0.93; Fig 2). EGF levels in fetal gastric fluid were higher in infused fetuses vs. controls (Table 1).…”

Section: Resultsmentioning

confidence: 91%

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Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development

Cellini

Jian

Arriaga

et al. 2004

Journal of Pediatric Surgery

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Section: Resultsmentioning

confidence: 91%

“…At term, the weight ratio of the IUGR fetus (ovarian end fetus 3) to the "favored" (Fav), or normal fetus (ovarian end fetus 1) is consistently 0.85 (Fig 1). 3 Epidermal growth factor (EGF) is a 53-amino-acid peptide that has extensive proliferative and maturative effects. EGF is present in amniotic fluid 4 and has a putative role in fetal development.…”

mentioning

confidence: 99%

Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development

Cellini

Jian

Arriaga

et al. 2004

Journal of Pediatric Surgery

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“…Thus, these results support our hypothesis that it is possible to induce a progressive model of fetal growth restriction. It could be argued that fetal position in the uterine horn, which is a 'natural model' of fetal growth restriction [10][11][12][13][14][15][16] , could influence these results. However, we have found that in our model, mortality rate and biometries of growth-restricted fetuses is not influenced by uterine position (results not shown).…”

Section: Discussionmentioning

confidence: 99%

“…The rabbit provides a natural model of IUGR based on fetal position within the uterus, but with an uncontrollable and mild effect on birth weight [10][11][12][13][14][15][16] . Food restriction models do not decrease fetal oxygen supply, which may be a critical factor in the pathogenesis of brain injury [17] .…”

Section: Introductionmentioning

confidence: 99%

An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

et al. 2009

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Introduction: To describe an animal model of growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit. Material and Methods: Two experimental protocols (+21 and +25 days of gestation) with three groups were defined: controls, mild (20–30%) and severe (40–50%) uteroplacental vessel ligature. Fetuses were delivered 120 h after the procedure by cesarean section. Biometrical measurements were carried out. Brains were obtained and glial response and cell proliferation were studied by S100β and Ki-67 immunohistochemistry. Results: Mortality rate and biometrical restriction increased across experimental groups according to the time and severity of the procedure. S100β expression was significantly higher in the severe reduction group at 25 days. Ki-67 expression was significantly higher in the mild reduction group at 21 days and in the severe reduction group at 25 days. Discussion: Selective ligature of uteroplacental vessels in the pregnant rabbit results in a gradual model of growth restriction in terms of mortality, biometrical restriction and histological brain changes.

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“…Models that use spontaneous differences in the perinatal environment stemming from different litter sizes (e.g., rodents [Kennedy, 1957;Aubert et al, 1980;Faust et al, 1980;Oscai, 1982;Bunag et al, 1990;Young, 2002]) or different positions in utero (e.g., rabbits [Flake et al, 1987;Buchmiller-Crair et al, 2001]) are valuable tools for determining the effects of the perinatal environment on growth, metabolism, cardiovascular function, and nervous system function. The marmoset monkey could be used in a similar fashion to examine the pre-and postnatal effects of litter size on growth, health, and lifespan in primates, given that marmosets have a variable litter size and a relatively short lifespan.…”

Section: Discussionmentioning

confidence: 99%

Relations among birth condition, maternal condition, and postnatal growth in captive common marmoset monkeys (Callithrix jacchus)

Tardif

Bales

2004

American J Primatol

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The present study characterizes the relations among maternal condition, litter size, birth condition, and growth in body weight for a population of common marmosets. The subjects of the study were marmosets born into a single colony between 1994 and 2001. Three sets of analyses were conducted to answer the following questions: 1) Is there a relationship between litter size, maternal condition, and birth condition? In the study population, maternal body weight, maternal age, litter size, and birth condition were related in a complex fashion. Birth weight and prenatal long-bone growth, as reflected in knee-heel length, were both related to maternal age, with older mothers supporting higher prenatal growth. Age and maternal condition appeared to interact as determinants of long-bone growth, as the combination of older and larger mothers resulted in significantly longer knee-heel lengths in their offspring. 2) Is there a relationship between birth condition or maternal condition and subsequent growth or final adult size? The early growth rate in this population was similar to early growth rates reported for three different marmoset colonies, suggesting that early growth may be relatively inflexible in this species. However, within this population, the variation that did occur in early growth rate was related to birth weight and maternal weight. Later growth and adult weight were related to birth weight and litter size: small twin infants displayed slower later growth rates and were smaller as adults than twins that began life at a higher birth weight, while the birth weight of triplets was not related to adult size. In these marmosets, small infants that were the result of increased litter size differed from small infants whose small birth size resulted from other factors. This reinforces the proposal that the causes of low birth weight will be relevant to the development of the marmoset as a model of prenatal environmental effects.

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Transamniotic fetal feeding II. A model of intrauterine growth retardation using the relationship of “Natural runting” to uterine position

Cited by 28 publications

References 15 publications

Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development

Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development

An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

Relations among birth condition, maternal condition, and postnatal growth in captive common marmoset monkeys (Callithrix jacchus)

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