“…However, these routes were abandoned after unfavorable outcomes due to difficulties in achieving a coaxial alignment of the THV and the mitral prosthesis. Thereafter, the team successfully performed all MVIVI via a transapical approach (10), which has been adopted as the default route by most other centers performing THV implantation in the mitral position(9,(11)(12)(13). Nevertheless, our results, associated with reports from other groups(8,22), suggest that THV implantation in the mitral position may be alternatively performed using the transseptal approach.…”