Transarterial Embolization and Chemoembolization

Boston, Sarah E.

doi:10.1002/9781118910924.ch65

Cited by 2 publications

(4 citation statements)

References 11 publications

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“…5 There are also various potential side effects and complications, for example, ischemic pain, hemorrhage, post-embolization syndrome, and damage of normal tissues and their function. 6,7 Most importantly, all present embolic materials have both merits and demerits in clinical applications, such as adhesion to the catheter, using of organic solvents, incomplete embolization or nontargeted embolization, vascular recanalization, toxicity, and difficulties in use. 8−10 In situ gelling polymer systems have certain advantages like minimal involvement of toxic byproducts or solvents, and they also exhibit viscoelastic flow under constant and low-frequency stress or lack ionic moieties to interact with a wide range of applied therapeutic agents.…”

Section: ■ Introductionmentioning

confidence: 99%

“…TAE, with quick and efficient effects, can be combined with other therapeutic methods easily; , however, it also has some insurmountable disadvantages in clinical practice, such as complicated procedures, catheter intervention required, and professional operation needed, and it is also highly affected by tumors, patterns, operators, and techniques . There are also various potential side effects and complications, for example, ischemic pain, hemorrhage, post-embolization syndrome, and damage of normal tissues and their function. , Most importantly, all present embolic materials have both merits and demerits in clinical applications, such as adhesion to the catheter, using of organic solvents, incomplete embolization or nontargeted embolization, vascular recanalization, toxicity, and difficulties in use. − In situ gelling polymer systems have certain advantages like minimal involvement of toxic byproducts or solvents, and they also exhibit viscoelastic flow under constant and low-frequency stress or lack ionic moieties to interact with a wide range of applied therapeutic agents. ,− …”

Section: Introductionmentioning

confidence: 99%

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A Simple and Efficient Embolization-Combined Therapy for Solid Tumors by Smart Poly(amino acid)s Nanocomposites

Chen

et al. 2022

ACS Appl. Bio Mater.

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Interventional embolization and minimally invasive thermal ablation are common clinical methods for treatment of unresectable solid tumors, but they both have many insurmountable disadvantages. Inspired by pH-responsive drug delivery systems, we report the tumor microenvironment-gelled nanocomposites with poly[(l-glutamic acid-ran-l-tyrosine)-b-l-threonine-b-l-cysteine]s (PGTTCs) coating nanoparticles (NPs, Au or Fe3O4) for noninterventional targeted embolization combined with noninvasive thermal ablation therapy of solid tumors by intravenous injection without catheter use. The results of the animal trial in vivo with tumor-bearing mice and rabbits showed superior targeted embolization and therapy and fluorescence/single-photon emission computed tomography/magnetic resonance multimodal imaging effects. Tumors treated with NPs@PGTTCs were shrunken and necrotized within 30 days, the long-term survival rate was more than 80%, and the same effects can be achieved within 15 days when combined with thermal ablation. The method is so simple and efficient for many hard-to-treat tumors within an acidic microenvironment, which is not only a great improvement and innovation in tumor theranostics but also an important development in nanomedicine.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Simple and Efficient Embolization-Combined Therapy for Solid Tumors by Smart Poly(amino acid)s Nanocomposites

Chen

et al. 2022

ACS Appl. Bio Mater.

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“…There also are many potential risks of side effects and complications, including nontarget embolization, ischemic pain, tumoral hemorrhage, postembolization syndrome, damage of normal tissue and its function, toxicity of the high dosage contrast agent, etc. 21 − 23 …”

Section: Introductionmentioning

confidence: 99%

“…The procedure of TAE is complicated and demanding, with one (or more) superselective catheterization requiring repeat contrast-injected real-time angiography throughout the procedure. There also are many potential risks of side effects and complications, including nontarget embolization, ischemic pain, tumoral hemorrhage, postembolization syndrome, damage of normal tissue and its function, toxicity of the high dosage contrast agent, etc. − …”

Section: Introductionmentioning

confidence: 99%

Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s

Wang

et al. 2020

ACS Cent. Sci.

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Transcatheter arterial embolization (TAE) has been widely applied in treatments of unresectable or hypervascular tumors, but the procedure of TAE is complicated possibly brings inherent risks. Here, inspired by pH-responsive drug delivery systems, a new method of noninvasive and target embolization therapy by intravenous injection was developed. This method is based on a type of acidic microenvironment-responsive hyperbranched poly(amino acid) (HPTTG) to avoid using catheterization and real-time image guidance angiography, simplifying the procedure, elevating compliance and general applicability of embolization therapy. The pH value of the sol-to-gel phase transition with decreasing pH of HPTTG was controlled by adjusting the ratio of acidic amino acids in copolymers. The results of the tumor-bearing animal experiment indicate that the HPTTG have an excellent target and embolic ability; they accumulate the most at the tumor site in 8 h postinjection. Blood vessels of the tumors were occluded, and the tumors were inhibited and necrotized in about 20 days. Therefore, it is expected that HPTTG not only can be used as novel embolic materials for efficient noninvasive embolization therapy of many solid tumors but also can be used as a multifunctional platform for combined theranostics, for example, combination with controlled release, thermal ablation, multimodal imaging, synergistic therapy, etc.

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Transarterial Embolization and Chemoembolization

Cited by 2 publications

References 11 publications

A Simple and Efficient Embolization-Combined Therapy for Solid Tumors by Smart Poly(amino acid)s Nanocomposites

A Simple and Efficient Embolization-Combined Therapy for Solid Tumors by Smart Poly(amino acid)s Nanocomposites

Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s

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