Transcatheter Aortic Valve Implantation in Singapore: Reflecting on the First Decade

Tay, Edgar

doi:10.47102/annals-acadmedsg.202082

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…This is in accordance with 7.8-19.4% in previous studies (Aquilanti et al, 2021;Bhaskar, 1968;Daley et al, 1994;de Souza et al, 2010;Grossmann et al, 2007;Jaeger et al, 2017;Jones et al, 2006;Kambalimath et al, 2014;Kammer et al, 2020;Mosqueda-Taylor et al, 2002;Ochsenius et al, 2007;Sharifian & Khalili, 2011;Tamiolakis et al, 2019;Tay, 1999;Tortorici et al, 2008), but higher than 4.56% reported by Butt et al (2011). OCs accounted for 89.47% of all CsOJ which is comparable to 92.9%-99.3% from previous studies (Aquilanti et al, 2021;Daley et al, 1994;Del Corso et al, 2014;Grossmann et al, 2007;Johnson et al, 2013 Soft tissue 0 (0%) 13 (0.16%) c 0 (0%) 0 (0%) Abbreviations: NOS, not otherwise specified; SD, standard deviation.…”

Section: Discussionsupporting

confidence: 93%

“…The oral cavity can be afflicted by myriad pathologies ranging from developmental lesions, infections, inflammatory lesions, immunologic disorders, cysts and benign and malignant tumours. Cysts of the jaws (CsOJ) constitute 1.11%–19.42% of all biopsy cases (Aquilanti et al, 2021; Bhaskar, 1968; Butt et al, 2011; Daley et al, 1994; de Souza et al, 2010; Grossmann et al, 2007; Jaeger et al, 2017; Jones et al, 2006; Kambalimath et al, 2014; Kammer et al, 2020; Mosqueda‐Taylor et al, 2002; Ochsenius et al, 2007; Sharifian & Khalili, 2011; Tamiolakis et al, 2019; Tay, 1999; Tortorici et al, 2008). They can be classified into odontogenic cysts (OCs) arising from epithelium associated with tooth forming apparatus or its remnants entrapped within the bone or gingival tissue; epithelial rest of Malassez, dental lamina or reduced enamel epithelium and non‐odontogenic cysts (NOCs) arising from ectoderm involved in the development of facial tissue (Jones et al, 2006; Ochsenius et al, 2007; Tekkesin et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Cysts of the jaws: A multicentre study

Dhanuthai,

Chantarangsu,

Klanrit

et al. 2023

Oral Diseases

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ObjectivesTo determine the relative frequency, demographic and pathologic profiles of patients diagnosed with cysts of the jaws.Materials and MethodsBiopsy records of the participating institutions from 2000 to 2020 were reviewed for lesions diagnosed in the cyst category. Demographic data, the location of the cysts and pathologic diagnoses were collected. Data were analyzed by appropriate statistics using IBM SPSS software version 28.0.ResultsFrom 148,353 accessioned cases, 25,628 cases (17.28%) were diagnosed in the cyst category. Mean age of the patients ± SD = 42.62 ± 19.36 years. Paediatric patients (aged ≤ 16 years) accounted for 9.63%, while geriatric patients (aged ≥ 65) comprised 14.22% of all the patients. The male‐to‐female ratio was 1.27:1. The majority of the lesions were encountered in the mandible. The most prevalent cyst was radicular cyst followed by dentigerous cyst and odontogenic keratocyst. In the paediatric group, dentigerous cyst was the most prevalent, whereas in the geriatric group, radicular cyst was the most common.ConclusionsIn general, the results of this study are in accordance with previous studies. This study provides an invaluable database for clinicians when formulating clinical differential diagnoses as well as for pathologists in rendering the final diagnosis.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Cysts of the jaws: A multicentre study

Dhanuthai,

Chantarangsu,

Klanrit

et al. 2023

Oral Diseases

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“…A few previous studies showed that cancer was the most common finding in oral specimens [1,4,18,[24][25]. Malignant tumors constituted 10% of the specimens in our series, which is close to what was reported in Libya (8%), the UAE (14.9%) and Iraq (14.5%) but higher than in Kuwait (3.6%), Spain (3.9%) and the UK (5.4%) [6,[24][25][26][27].…”

Section: Discussionsupporting

confidence: 88%

“…Odontogenic cysts are heterogenous diseases that arise from odontogenic epithelium [3]. Similar to our study, radicular cysts were the most common odontogenic cyst, followed by dentigerous and then keratocysts [17][18][19][20][21]. Radicular cysts typically complicate inflammatory conditions such as trauma or dental caries, while dentigerous cysts are a developmental anomaly associated with an unerupted tooth.…”

Section: Discussionsupporting

confidence: 84%

The Spectrum of Oral Pathology Specimens: A Histopathologic Analysis of 442 Specimens

Aladily¹,

Eid²,

Waia³

et al. 2023

Jordan Med. J.

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Background Aims: Diseases of the oral cavity are heterogenous regarding their etiology, pathogenesis, histogenesis and clinical outcomes. The aim of this study was to examine the frequency of oral diseases encountered in our experience. Methods: The archives of pathology at Jordan University Hospital were retrospectively searched for oral cavity specimens from 2013–2020. Fisher’s exact test was performed to examine the statistical difference between the pathologic diagnosis and clinical variables. One-way ANOVA was used to analyze the differences in the mean of age between the different pathologic groups. Results: A total of four-hundred and forty-two cases were retrieved. There were 232 (52%) females and 210 (48%) males, ranging in age from 3–87 years (mean 43). Inflammatory and reactive diseases were the most common, constituting 147 (33%) of all specimens, followed by 139 (31%) benign neoplasms, 114 (26%) cysts, and 42 (10%) malignant diseases. Lichen planus was the most common inflammatory disease (26/147, 18%) in patients older than 40 (p=0.0039). Keratocysts predominated in children and adolescents more than adults (p=0.0015). Buccal mucosa represented the most frequent site for biopsy (76, 17%), followed by tongue and maxillary bone, respectively at 70 (16%) each. Conclusion: Inflammatory and benign neoplasms were the most common lesions in oral diseases. Oral malignancy appeared in low to intermediate frequency compared to previous reports. The study provides a general overview of the spectrum of oral pathology specimens and points to some novel epidemiologic findings that suggest further investigation.

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Cost-Effectiveness of Transcatheter Aortic Valve Implantation in Intermediate and Low Risk Severe Aortic Stenosis Patients in Singapore

Kuntjoro

Tay

Hon

et al. 2020

Ann Acad Med Singap

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Introduction: Singapore has the world’s second most efficient healthcare system while costing less than 5% GDP. It remains unclear whether transcatheter aortic valve implantation (TAVI) is cost-effective for treating intermediate-low risk severe aortic stenosis (AS) patients in a highly efficient healthcare system. Materials and Methods: A two-phase economic model combining decision tree and Markov model was developed to assess the costs, effectiveness, and the incremental cost-effectiveness ratio (ICER) of transfemoral (TF) TAVI versus surgical aortic valve replacement (SAVR) in intermediate-low risk patients over an 8-year time horizon. Mortality and complications rates were based on PARTNER 2 trial cohort A and Singapore life table. Costs were mainly retrieved from Singapore National University Health System database. Health utility data were obtained from Singapore population based on the EuroQol-5D (EQ-5D). A variety of sensitivity analyses were conducted. Results: In base case scenario, the incremental effectiveness of TF-TAVI versus SAVR was 0.19 QALYs. The ICER of TF-TAVI was S$33,833/QALY. When time horizon was reduced to 5 years, the ICER was S$60,825/QALY; when event rates from the propensity analysis was used, the ICER was S$21,732/QALY and S$44,598/QALY over 8-year and 5-year time horizons, respectively. At a willingness to pay threshold of S$73,167/QALY, TF-TAVI had a 98.19% probability of being cost-effective after 100,000 simulations. The model was the most sensitive to the costs of TF-TAVI procedure. Conclusion: TF-TAVI is a highly cost-effective option compared to SAVR for intermediate-low risk severe AS patients from a Singapore healthcare system perspective. Increased procedure experience, reduction in device cost, and technology advance may have further increased the cost-effectiveness of TF-TAVI per scenario analysis. Keywords: Surgical aortic valve replacement, Quality of life, Transfemoral TAVI, Reimbursement

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Transcatheter Aortic Valve Implantation in Singapore: Reflecting on the First Decade

Cited by 3 publications

References 7 publications

Cysts of the jaws: A multicentre study

Cysts of the jaws: A multicentre study

The Spectrum of Oral Pathology Specimens: A Histopathologic Analysis of 442 Specimens

Cost-Effectiveness of Transcatheter Aortic Valve Implantation in Intermediate and Low Risk Severe Aortic Stenosis Patients in Singapore

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