Transcatheter aortic valve replacement (TAVR) is traditionally indicated for calcific aortic stenosis. Rheumatic aortic valve disease is treated surgically due to the younger age of patients and a lack of significant calcification that can anchor transcatheter valves. However, severe comorbidities may increase surgical risk, necessitating less invasive therapeutic modalities. Here, we present the first case report of severe rheumatic aortic stenosis with prior mechanical mitral valve prosthesis and liver cirrhosis that was successfully treated by TAVR.