Transcatheter Arterial Infusion with Heated Saline Changes the Vascular Permeability of Rabbit Hepatic Tumors

Cao, Wei; Lü, Qiang; Liu, Jinghua; Zhou, Changxi; Zhu, Jiang; Wan, Yi; Liu, Yufeng

doi:10.1016/j.acra.2011.08.010

Cited by 4 publications

(3 citation statements)

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“…Because the VEGF protein expression in tumors may respond to heat [11] and the viable tumor vascular endothelial cells are sensitive to heat injury [20], and mass spectrometric analysis of drug showed that cisplatin is not affected by heat [21], and doxorubicin and mitomycin-C are also not degraded at temperatures of 60 degrees C [21], heated lipiodol as a new embolic agent via hepatic artery administration can distribute heat and emulsify conventional TACE drugs (doxorubicin, mitomycin-C, cisplatin) to the entire tumor and may affect VEGF protein expression levels in the tumor or the tumor vasculature.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, this treatment affects serum AST levels similar to lipiodol at 37°C [10]. In vivo studies have also demonstrated that heated saline infusion via the hepatic artery can alter the tumor vascular permeability by affecting the expression levels of VEGF or VEGFR [11], [12] because these two proteins are two important factors related to tumor angiogenesis [13], [14]. Therefore, the aim of this study was to observe the changes in tumor angiogenesis and analyze the underlying causes after trans-hepatic, arterial, heated (60°C) lipiodol embolization via the hepatic artery in a rabbit model of VX2 liver cancer.…”

Section: Introductionmentioning

confidence: 98%

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Tumor Angiogenesis after Heated Lipiodol Infusion via the Hepatic Artery in a Rabbit Model of VX2 Liver Cancer

Cao

Zhang

et al. 2013

PLoS ONE

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ObjectivesThis study aimed to observe the changes in tumor angiogenesis after heated lipiodol (60°C) infusion via the hepatic artery in a rabbit model of VX2 liver cancer.Materials and MethodsTwenty rabbits with VX2 hepatic tumors were randomly divided into 2 groups (10 rabbits in each group). Under anesthesia, a trans-catheter hepatic arterial infusion was performed, and lipiodol (37°C; control group) or heated lipiodol (60°C; treated group) was injected into the hepatic arteries of the animals. Then, changes in tumor angiogenesis were assessed using the following markers and methods. 1. Vascular endothelial growth factor receptor (VEGFR) and vascular endothelial growth factor (VEGF) expression levels in the tumor were assessed using western blotting and real-time quantitative polymerase chain reaction (PCR). 2. Proliferating cell nuclear antigen (PCNA) expression in the tumor was assessed through immunohistochemical staining. 3. The morphological changes in tumor vascular endothelial cells were observed using transmission electron microscopy (TEM).ResultsVEGFR and VEGF mRNA and protein expression levels were reduced in the treated group compared to the control group. PCNA protein showed reduced expression levels in the treated group compared to the control group. TEM indicated that the endothelial cell endoplasmic reticulum expanded, the chondriosome was swollen, and the endothelial cell microvilli were decreased after heated lipiodol infusion.ConclusionsThe tumor angiogenesis of rabbits with VX2 cancer was inhibited after arterial heated lipiodol infusion compared to lipiodol infusion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Tumor Angiogenesis after Heated Lipiodol Infusion via the Hepatic Artery in a Rabbit Model of VX2 Liver Cancer

Cao

Zhang

et al. 2013

PLoS ONE

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“…By comparison, ablative level temperatures would be expected to cause vascular damage, coagulation, vessel occlusion, and ischemia. Examples of heated solutions used to deliver heat energy in a locoregional manner include warmed saline and heated ethiodized oil [43][44][45][46][47]. The use of hyperthermia for ablation delivered via catheter seems initially to be an appealing strategy, but it does have limitations.…”

Section: Adjunct Strategies: Transcatheter Hyperthermia and Nanotechnologiesmentioning

confidence: 99%

Combining Chemistry and Engineering for Hepatocellular Carcinoma: Nano-Scale and Smaller Therapies

et al. 2020

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Primary liver cancer, or hepatocellular carcinoma (HCC), is a major worldwide cause of death from carcinoma. Most patients are not candidates for surgery and medical therapies, including new immunotherapies, have not shown major improvements since the modest benefit seen with the introduction of sorafenib over a decade ago. Locoregional therapies for intermediate stage disease are not curative but provide some benefit. However, upon close scrutiny, there is still residual disease in most cases. We review the current status for treatment of intermediate stage disease, summarize the literature on correlative histopathology, and discuss emerging methods at micro-, nano-, and pico-scales to improve therapy. These include transarterial hyperthermia methods and thermoembolization, along with microfluidics model systems and new applications of mass spectrometry imaging for label-free analysis of pharmacokinetics and pharmacodynamics.

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Changes in Hepatic Blood Flow During Transcatheter Arterial Infusion with Heated Saline in Hepatic VX2 Tumor

Cao

et al. 2012

Cardiovasc Intervent Radiol

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Transcatheter Arterial Infusion with Heated Saline Changes the Vascular Permeability of Rabbit Hepatic Tumors

Cited by 4 publications

References 20 publications

Tumor Angiogenesis after Heated Lipiodol Infusion via the Hepatic Artery in a Rabbit Model of VX2 Liver Cancer

Tumor Angiogenesis after Heated Lipiodol Infusion via the Hepatic Artery in a Rabbit Model of VX2 Liver Cancer

Combining Chemistry and Engineering for Hepatocellular Carcinoma: Nano-Scale and Smaller Therapies

Changes in Hepatic Blood Flow During Transcatheter Arterial Infusion with Heated Saline in Hepatic VX2 Tumor

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