Transcatheter edge to edge repair using the ease-of-use valve clamp system for functional mitral regurgitation: a primary report

Li, Wei; Long, Yuliang; Pan, Wenzhi; Wei, Lai; Pan, Cuizhen; Guan, Lina; Zhou, Daxin; Ge, Junbo

doi:10.1007/s00595-022-02559-8

Cited by 2 publications

(9 citation statements)

References 22 publications

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“…[25][26][27] Data on short-term all-cause mortality for both groups was available in four studies. [23][24][25]27 Two studies assessed mortality at 30 days, 24,27 while another assessed in-hospital mortality (median hospital stay: 4 [interquartile range 2-7]). 23 Li et al reported no deaths during the follow-up period.…”

Section: Results Of Individual Studies and Synthesis Of Resultsmentioning

confidence: 99%

“…A total of eight studies had data available for short‐term outcomes of postprocedural MR ≤ 2 in both AFMR and VFMR groups, with a total of 539 and 3486 individuals, respectively 14–16,23–27 . Meanwhile, three studies with a total of 192 and 694 individuals reported long‐term postprocedural MR ≤ 2 outcomes in both groups 16,26,27 .…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, there was no statistical difference in short‐ or long‐term outcomes of postprocedural NYHA ≤ 2 between the two groups (RR, 1.09 [95% CI, 0.93–1.29], p = 0.28, I 2 = 0% for short term and RR, 1.07 [95% CI, 0.86–1.34], p = 0.52, I 2 = 0% for long term; Figure 3). 25–27 …”

Section: Resultsmentioning

confidence: 99%

“…Two studies assessed mortality at 30 days, 24,27 while another assessed in‐hospital mortality (median hospital stay: 4 [interquartile range 2–7]) 23 . Li et al reported no deaths during the follow‐up period 25 . No statistical significance was observed in the short‐term all‐cause mortality between the two groups (pooled RR, 0.91 [95% CI, 0.30–2.75]; p = 0.87, I 2 = 0%).…”

Section: Resultsmentioning

confidence: 99%

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Outcomes of transcatheter edge‐to‐edge repair for atrial functional mitral regurgitation: A meta‐analysis of observational studies

Hamada,

Ueyama,

Aikawa

et al. 2023

Cathet Cardio Intervent

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BackgroundTranscatheter edge‐to‐edge repair (TEER) may have potential benefits in the treatment of atrial functional mitral regurgitation (AFMR), but robust evidence is currently lacking. We conducted a systematic review and meta‐analysis to investigate the clinical outcomes of TEER for AFMR, including comparisons to ventricular functional MR (VFMR).MethodsMEDLINE and EMBASE were searched through January 2023 to identify studies eligible for analysis. The primary outcome was postprocedural MR severity. Postprocedural New York Heart Association (NYHA) functional class classification and all‐cause mortality were also evaluated. Outcomes were stratified into short term (postprocedure to 6 months) and long term (6 months to 2 years).ResultsA total of eight observational studies met the inclusion criteria, enrolling 539 AFMR and 3486 VFMR patients. Postprocedural MR grade ≤2 in the AFMR group was observed in 93.7% (454/491 patients; 95% confidence interval (CI), 91.1%–96.2%, I2 = 24.3%) and 97.1% (89/93 patients; 95% CI, 92.9%–100%, I2 = 26.4%) in short‐ and long‐term follow‐up, respectively. There was no difference in the rates of postprocedural MR grade ≤2 between AFMR and VFMR either in short‐term (risk ratio [RR], 1.00 [95% CI, 0.95–1.06]; p = 0.90; I2 = 53%) or long‐term follow‐up (RR, 1.08 [95% CI, 0.89–1.32]; p = 0.44; I2 = 22%). Similarly, no difference was observed between AFMR and VFMR in the rates of postprocedural NYHA class ≤2 or all‐cause mortality.ConclusionTEER provides similar clinical outcomes for AFMR and VFMR. A high rate of MR grade ≤2 was observed in patients at both short‐ and long‐term follow‐ups. Further prospective studies with TEER versus medical therapy and/or rhythm control for AFMR are warranted.

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Section: Results Of Individual Studies and Synthesis Of Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Outcomes of transcatheter edge‐to‐edge repair for atrial functional mitral regurgitation: A meta‐analysis of observational studies

Hamada,

Ueyama,

Aikawa

et al. 2023

Cathet Cardio Intervent

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“…FMR patients with baseline New York Heart Association functional Class III/IV (100%) showed improvement of at least 1 class after TEER with the ValveClamp system at the 3-month follow-up. 9 …”

Section: Introductionmentioning

confidence: 99%

A case report of transcatheter repair of severe functional mitral regurgitation in cardiac amyloidosis

Fangmin

Wei

et al. 2022

European Heart Journal - Case Reports

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Background Transcatheter therapy has become an alternative for functional mitral regurgitation (FMR) in patients at high surgical risk. However, the intervention of FMR in cardiac amyloidosis (CA) with transcatheter edge-to-edge repair (TEER) is controversial due to the potential risk of left atrial pressure (LAP) elevation. Case summary An 83-year-old woman with repeated heart failure (HF) and severe mitral regurgitation (MR) was referred to our centre for TEER. Pre-procedural transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) confirmed the degree of MR and a functional aetiology. A peculiar LAP increase in this patient occurred immediately after successful TEER clip implantation and her N-terminal prohormone of brain natriuretic peptide significantly increased post-operatively. The diagnosis of CA was suspected and was subsequently established through endomyocardial biopsy. Aggressive anti-HF therapy was initiated and the patient was discharged after her HF symptoms were relieved. At 6-month follow-up, the patient was still alive and no episode of acute HF was experienced. Discussion Severe functional MR in CA treated with TEER has the potential risk of increasing LAP. During the short-term follow-up, TEER appears beneficial for left-heart function (reduction of MR) but harmful for right-heart function (increase of LAP). CA patients with severe FMR should be carefully evaluated about the benefits and potential harm of TEER intervention.

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Transcatheter edge to edge repair using the ease-of-use valve clamp system for functional mitral regurgitation: a primary report

Cited by 2 publications

References 22 publications

Outcomes of transcatheter edge‐to‐edge repair for atrial functional mitral regurgitation: A meta‐analysis of observational studies

Outcomes of transcatheter edge‐to‐edge repair for atrial functional mitral regurgitation: A meta‐analysis of observational studies

A case report of transcatheter repair of severe functional mitral regurgitation in cardiac amyloidosis

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