Transcatheter obliteration of the renal artery by ethanol injection: Experimental results

Ekelund, Leif; Jonsson, Nils; Treugut, H.

doi:10.1007/bf02552398

Cited by 56 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Organization of these initially thrombotic occlusions into mature, fibrotic CTOs was evident at 4 weeks in the porcine model and by 10 weeks in the rabbit model. Other CTO models have included stents with occluded outflow 46 and even direct alcohol injection 47 to promote thrombosis.…”

Section: Preclinical Models Of Ctosmentioning

confidence: 99%

Percutaneous Recanalization of Chronically Occluded Coronary Arteries

et al. 2005

View full text Add to dashboard Cite

R emarkable progress in the percutaneous management of coronary artery disease has been achieved over the last decade. The scaffolding properties of coronary stents have resulted in percutaneous coronary intervention (PCI) becoming a predictable procedure, with reduced rates of acute closure and late restenosis compared with balloon angioplasty alone. 1,2 More recently, the site-specific delivery of antiproliferative agents from drug-eluting stents has been demonstrated to markedly attenuate vascular responses leading to neointimal hyperplasia, further reducing the occurrence of clinical and angiographic restenosis to Ͻ10% in most patients. 3,4 PCI in patients with acute coronary syndromes and acute myocardial infarction (AMI) has also been proven to save lives, reduce rates of myocardial infarction (MI), and enhance quality of life compared with alternative treatment modalities. [5][6][7] With these advances in perspective, it is often stated that successful recanalization of chronic total occlusions (CTOs) of native coronary arteries represents the "last frontier" of PCI. This statement is made in deference to the fact that CTOs represent the most technically challenging lesion subset that interventional cardiologists face, with procedural success rates considerably lower than those achieved in nonoccluded coronary vessels or acutely occluded arteries. Moreover, no consensus exists with regard to the definition of CTO, the factors related to procedural failure and/or complications, and the optimal technical approach. Indeed, until recently, the clinical benefits of PCI in CTOs had not been demonstrated.An international panel of 47 physicians from 9 countries was therefore convened in New York City for 2 days in January 2004, the purpose of which was to reach consensus on the current state of the art of CTO angioplasty (see Appendix in the online-only Data Supplement for a complete participant list). This goal was approached through a series of didactic lectures, roundtable discussions, breakout focus groups, and the performance of 14 live case demonstrations of CTO angioplasty by many of the world's most skilled operators in this subspecialty. The present report represents a synthesis of the findings from this meeting and also incorporates a literature review from the field of CTO intervention. Topics covered in Part I of this review include definitions, prevalence, and clinical presentation of CTOs; the anatomy and histopathology of coronary occlusions; experimental CTO models; and the clinical relevance and rationale for CTO revascularization. Part II will review the technical approach to and clinical outcomes after percutaneous intervention of CTOs and describe the novel devices and drugs approved and undergoing investigation for CTO recanalization.

show abstract

Section: Preclinical Models Of Ctosmentioning

confidence: 99%

Percutaneous Recanalization of Chronically Occluded Coronary Arteries

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The advantages of absolute ethanol over other embolic agents are that it is (1) inexpensive, (2) easy to handle, (3) easy to deliver through small catheters, (4) provides complete infarction with both cellular death and second ary vascular thrombus without evidence of collateraliza tion, and (5) shows a low risk of complications such as abscess formation and reflux to other organs [13,14].…”

Section: Methodsmentioning

confidence: 99%

Renal Ablation with Absolute Ethanol for Nonfunctioning Hydronephrosis

Hirao¹,

Okajima²,

Yoshida³

et al. 1993

Eur Urol

View full text Add to dashboard Cite

“…One of the techniques available for permanent vascular occlusion seems to be the use of the Gianturco stainless steel coil [4,18,19]. Ekelund et al used steel coils for therapeutic embolic occlusion of the renal artery in nine human patients with inoperable renal carcinoma, and no complications were seen without any evidence of recanalization at follow-up arteriograms [8]. However, they reported the risk of peripheral embolization, pseudoaneurysm formation and drawback of Gianturco coils and therefore, obliteration of the renal artery by ethanol injection was very safe and convenient in experimental model.…”

Section: Discussionmentioning

confidence: 99%

“…Iohexol-ethanol solution was employed for the treatment of hydronephrosis because it is easy to deliver through small catheters. Also, it is inexpensive, easy to handle, and it provides complete infarction with both cellular death and secondary vascular thrombus without evidence of collateralization, and shows a low risk of complications such as reflux to other organs [8,9].…”

Section: Discussionmentioning

confidence: 99%

Application of Transarterial Embolization of Renal Artery in Rabbits with Experimental Hydronephrosis.

Chang

Seo

Choi

et al. 2002

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. This study was performed to validate the procedure of transarterial embolization of the renal artery (TAE-RA) using iohexolethanol solution in rabbits with unilateral experimental hydronephrosis and to evaluate the embolized kidney and contralateral normal kidney using B-mode ultrasonography and color Doppler ultrasonography. Experimental hydronephrosis was induced at 17 days after ligation of unilateral ureter in 13 rabbits. Renal artery embolization was performed using selective catheterization in the hyd ronephrotic kidney of eight rabbits and electrocardiography, oxygen saturation, body temperature, pulse, and respiratory rate were within normal ranges during procedures. Iohexol-ethanol solution was used as embolic material. Average ethanol dose for renal artery embolization was 1.4 ± 0.7 ml/kg. There were no rabbits expired after TAE-RA and no side effects associated with regurgitation of iohexol-ethanol solution. In color Doppler ultrasonographic findings, there was no blood flow into the embolized kidneys treated by TAE-RA, how ever, blood flow signal was found in hydronephrotic kidney not treated by TAE-RA. Ultrasonographically, the mean longitudinal length of the embolized kidney significantly decreased at 2 and 3 months after TAE-RA. No significant difference of resistive index values was found between contralateral normal kidney of rabbits treated by TAE-RA and contralateral normal kidneys of rabbits treated with nephrectomy. We may conclude that TAE-RA with iohexol-ethanol solution is a viable alternative to nephrectomy in rabbits with unilateral hydronephrosis. KEY WORDS: color Doppler ultrasonography, hydronephrosis, iohexol-ethanol, rabbit, renal artery embolization.

show abstract

Transcatheter obliteration of the renal artery by ethanol injection: Experimental results

Cited by 56 publications

References 22 publications

Percutaneous Recanalization of Chronically Occluded Coronary Arteries

Percutaneous Recanalization of Chronically Occluded Coronary Arteries

Renal Ablation with Absolute Ethanol for Nonfunctioning Hydronephrosis

Application of Transarterial Embolization of Renal Artery in Rabbits with Experimental Hydronephrosis.

Contact Info

Product

Resources

About