2020
DOI: 10.1002/clc.23454
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Transcatheter vs surgical aortic valve replacement in low to intermediate surgical risk aortic stenosis patients: A systematic review and meta‐analysis of randomized controlled trials

Abstract: Background: Transcatheter aortic valve replacement (TAVR) is regarded as the most superior alternative treatment approach for patients with aortic stenosis (AS) who are associated with high surgical risk, whereas the effectiveness of TAVR vs surgical aortic valve replacement (SAVR) in low to intermediate surgical risk patients remained inconclusive. This study aimed to determine the best treatment strategies for AS with low to intermediate surgical risk based on published randomized controlled trials (RCTs).

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Cited by 8 publications
(13 citation statements)
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“…The duration of intensive care unit stay was also shorter in the TAVR group than in the SAVR group. These merits of TAVR have already been discussed in previous studies [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 58%
“…The duration of intensive care unit stay was also shorter in the TAVR group than in the SAVR group. These merits of TAVR have already been discussed in previous studies [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 58%
“…6 They demonstrate that in the RCT meta-analysis, although TAVR compared with SAVR was associated with a lower risk of operative mortality (0.66% vs 1.5%;individualstudiesdidnotshowdifference),therewasno difference in 1-year all-cause mortality in low-surgical risk patients.Thisfindingisconsistentwithotherrecentmeta-analyses of the data. [7][8][9] The low-risk cohort also had lower perioperative stroke with TAVR than SAVR (0.4% vs 1.4%) but individual RCTs for either low-or intermediate-risk patients have not shown significantdifferenceon1-yearto2-yearfollow-up. 2,4,10 Despite these recent trials of low-to intermediate-surgical risk patients, the decision to undertake TAVR or SAVR is a nuanced one.…”
mentioning
confidence: 88%
“…This finding is consistent with other recent meta-analyses of the data. 7 -9 The low-risk cohort also had lower perioperative stroke with TAVR than SAVR (0.4% vs 1.4%) but individual RCTs for either low- or intermediate-risk patients have not shown significant difference on 1-year to 2-year follow-up. 2,4,10…”
mentioning
confidence: 90%
“…59,60 In addition to the complication of paravalvular leak, transcatheter aortic valves frequently require pacemaker implantation, but have a decreased risk for stroke when compared to surgical aortic valve replacement. 61,62 The CHOICE trial examined the differences in clinical outcomes after 5 years between Nitinol self-expanding valves and balloon-expanding valves. They noted no difference in all-cause mortality or paravalvular leak.…”
Section: Shape Memory Alloys In Transcatheter Valvesmentioning
confidence: 99%