2017
DOI: 10.1016/j.neuron.2017.10.006
|View full text |Cite
|
Sign up to set email alerts
|

Transcellular Nanoalignment of Synaptic Function

Abstract: Summary At each of the brain’s vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a trans-cellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to understand how these compartments are structurally registered and functionally integrated with one another. This review will describe the organization of each compartment and then discuss … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

8
268
1

Year Published

2018
2018
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 304 publications
(301 citation statements)
references
References 239 publications
(333 reference statements)
8
268
1
Order By: Relevance
“…Amongst these critical scaffold proteins are Rab-interacting molecules (RIMs), Munc13/Unc13, RIM-binding proteins (RBPs), and ELKs family proteins [5]. By super-resolution imaging, these scaffolds form nanoclusters typically of ~60 to 80 nm within the AZ [2**, [6, [7**].…”
Section: Transsynaptic Alignment Can Control Synaptic Functionmentioning
confidence: 99%
See 2 more Smart Citations
“…Amongst these critical scaffold proteins are Rab-interacting molecules (RIMs), Munc13/Unc13, RIM-binding proteins (RBPs), and ELKs family proteins [5]. By super-resolution imaging, these scaffolds form nanoclusters typically of ~60 to 80 nm within the AZ [2**, [6, [7**].…”
Section: Transsynaptic Alignment Can Control Synaptic Functionmentioning
confidence: 99%
“…1). Such alignment is important because the surprisingly small amount of glutamate released from a single vesicle is not likely to activate relatively distant receptors before dispersing by diffusion [5, [14, [17, [18]. Direct experimental support for the idea that spatially confined subsets of receptors are activated by single vesicles remains elusive, but there is substantial indirect evidence [19, [20, [21, [22].…”
Section: Transsynaptic Alignment Can Control Synaptic Functionmentioning
confidence: 99%
See 1 more Smart Citation
“…Whereas most AMPARs are mainly permeable for Na + (and K + ), NMDARs also conduct Ca 2+ (Fig ). AMPARs and NMDARs are clustered at the postsynaptic density (PSD), a protein‐dense meshwork, and precisely juxtaposed to the presynaptic active zone (Tang et al, ; Biederer et al, ) for fast and efficient postsynaptic responses (Clements et al, ).…”
Section: Ampars and Nmdarsmentioning
confidence: 99%
“…Localization of AMPARs in those nanoclusters is thought to be functionally important because affinity of AMPARs for glutamate is fairly low and only AMPARs that are exactly juxtaposed to presynaptic release sites might be effectively activated (Franks et al, 2003;Lisman & Raghavachari, 2006). In fact, those nanoclusters appear to be closely aligned with presynaptic release sites for fast and efficient synaptic transmission (Tang et al, 2016;Biederer et al, 2017;Hruska et al, 2018). New functional evidence for this hypothesis has recently been provided by optogenetically induced binding of GluA1 to postsynaptic proteins (Sinnen et al, 2017).…”
Section: Postsynaptic Distribution Of Ampars and Nmdarsmentioning
confidence: 99%