“…Previous studies, however, did not find an association between this polymorphism and either holotranscolbalamin [41] or Hcy [38,42]. Furthermore, an increase in Hcy concentration was shown to be associated with the heterozygous TCN2 776 CG genotype when compared to the homozygous genotypes [36]. The discrepancy between these studies may be the result of several variables, such as differences in age, ethnicity, gender of the study subjects, folate intake, vitamin B 12 and B 6 intakes, genetic factors, and study design [4,43,44].…”