Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery

Souza, J. C.; Dias, Karina; Silva, Silas Arandas Monteiro e; Rezende, Lucas Cunha Dias de; Rocha, Eduardo Melani; Emery, Flávio da Silva; Lopez, Renata Fonseca Vianna

doi:10.1016/j.jconrel.2014.12.037

Cited by 46 publications

(30 citation statements)

References 44 publications

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“…Dendrimers of different generations (G2, G3, and G4) and surface groups (carboxyl, amine, and hydroxyl) have been synthesized and applied for effective ocular drug delivery including both anterior and posterior segments (Figure ).…”

Section: Nanostructured Drug Delivery Systemsmentioning

confidence: 99%

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

Bisht

Mandal

Jaiswal

et al. 2017

WIREs Nanomed Nanobiotechnol

102

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Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high drug concentrations in vitreous and retina. However, these repetitive injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery could overcome some of these unmet needs and various preclinical studies conducted to date have demonstrated promising results of nanotherapies in the treatment of retinal diseases. Compared to the majority of commercially available ocular implants, the biodegradable nature of most nanoparticles (NPs) avoids the need for surgical implantation and removal after the release of the payload. In addition, the sustained drug release from NPs over an extended period of time reduces the need for frequent intravitreal injections and the risk of associated side effects. The nanometer size and highly modifiable surface properties make NPs excellent candidates for targeted ocular drug delivery. Studies have shown that nanocarriers enhance the intravitreal half-life and thus bioavailability of a number of drugs including proteins and peptides. In addition, they have shown promising results in delivering genetic material to the retinal tissues by protecting it from possible intravitreal degradation. This review covers the various challenges associated with drug delivery to the posterior segment of the eye, particularly the retina, and highlights the application of nanocarriers to overcome these challenges in context with recent advances in preclinical studies. WIREs Nanomed Nanobiotechnol 2018, 10:e1473. doi: 10.1002/wnan.1473 This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanomaterials and Implants.

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Section: Nanostructured Drug Delivery Systemsmentioning

confidence: 99%

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

Bisht

Mandal

Jaiswal

et al. 2017

WIREs Nanomed Nanobiotechnol

102

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“…In a recent study, fourth‐generation PAMAM dendrimers were employed for iontophoresis targeted sustained DEX delivery to cornea. Ex vivo and in vivo corneal penetration was evaluated and it was reported that dendrimer complexation significantly increased the water solubility of DEX and transcorneal iontophoresis increased the amount of DEX that penetrated into the cornea, and also the sustained delivery of DEX from PAMAM prevented the rapid elimination . These results suggested that PAMAM dendrimers are promising topical drug delivery systems for cornea; however, the drug transport to the back of the eye has not been investigated in this study.…”

Section: Resultsmentioning

confidence: 88%

In Vitro/In Vivo Evaluation of Dexamethasone—PAMAM Dendrimer Complexes for Retinal Drug Delivery

Yavuz

Pehlivan

Vural

et al. 2015

Journal of Pharmaceutical Sciences

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“…1,2 Several studies evaluated the influence of iontophoresis on enhancing the skin penetration of drugs, and assessed its applicability as a tool in treating skin and eye diseases. 3,4,5 One of the advantages of using iontophoresis in dentistry is that it is a non-invasive method, whereby the drugs are administered directly at the treatment site with minimized adverse effects. 6,7 Data on the use of iontophoresis with dental substances or compounds is still sparse in the Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

Effect of iontophoresis on fluoride uptake in enamel with artificial caries lesion

et al. 2019

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Iontophoresis is a noninvasive technique, based on the application of a constant low-intensity electric current to facilitate the release of a variety of drugs, whether ionized or not, through biological membranes. The objective of this research was to evaluate the effect of iontophoresis using different electric current intensities on the uptake of fluoride in dental enamel with artificial caries lesions. In this in vitro operator-blind experiment, bovine enamel blocks (n = 10/group) with caries-like lesions and predetermined surface hardness were randomized into 6 groups: placebo gel without fluoride applied with a current of 0.8 mA (negative control), 2% NaF gel without application of any current, and 2% NaF gel applied with currents of 0.1, 0.2, 0.4 and 0.8 mA. Cathodic iontophoresis was applied for 4 min. The concentration of loosely bound fluoride (calcium fluoride) and firmly bound fluoride (fluorapatite) was determined. The results were analyzed by the nonparametric Kruskal-Wallis and Dunn tests. Iontophoresis at 0.8 mA, combined with the application of fluoridated gel (2% NaF), increased fluoride uptake in enamel with caries-like lesions, as either calcium fluoride or fluorapatite.

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Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery

Cited by 46 publications

References 44 publications

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

In Vitro/In Vivo Evaluation of Dexamethasone—PAMAM Dendrimer Complexes for Retinal Drug Delivery

Effect of iontophoresis on fluoride uptake in enamel with artificial caries lesion

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