Transcortin: A Corticosteroid-Binding Protein of Plasma. XI. Effects of Estrogens or Pregnancy in Guinea Pigs

He, Rosenthal; Wr, Slaunwhite; Aa, Sandberg

doi:10.1210/endo-85-5-825

Cited by 26 publications

(12 citation statements)

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“…Support for this hypothesis may be found in those studies that demonstrate that the biosynthesis of transcortin is induced by estrogen and that increases in plasma estrogen during pregnancy are paralleled by increases in maternal plasma transcortin (25,26). We feel that during the first trimester, the increased level of transcortin in maternal plasma is the result of its induced biosynthesis by the liver in response to estrogenic increases.…”

Section: Discussionmentioning

confidence: 69%

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Placenta, transcortin, and localized immune response.

Werthamer¹,

Govindaraj²,

Amaral³

1976

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 69%

“…Transcortin is markedly and continuously increased during pregnancy (23,24). This increase is due to increased synthesis induced by elevations of plasma estrogens (25,26) and occurs exclusively in the liver (27,28). It is possible, therefore, that increased levels of transcortin could result in the suppression of cell-mediated immunity.…”

Section: Introductionmentioning

confidence: 99%

Placenta, transcortin, and localized immune response.

Werthamer¹,

Govindaraj²,

Amaral³

1976

J. Clin. Invest.

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“…It is probable that high-affinity proteins in the blood reduce hepatic uptake. The concentration of plasma transcortin is higher in non-pregnant guinea-pigs than in man (Rosenthal, Slaunwhite & Sandberg, 1969) and has an association constant for progesterone even greater than that for cortisol and corticosterone (Westphal, 1967). Hence, if splanchnic extraction is similar to that in man (about 70%, Little, Bougas, Tait & Tait, 1963), the extra-hepatic clearance of progesterone could be 62 % of the total.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Metabolic Clearance Rate of Progesterone in the Guinea-Pig

Illingworth¹,

Heap²,

Perry³

1970

Journal of Endocrinology

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The metabolic clearance rate (MCR) of progesterone was measured by continuous infusion of the tritium-labelled steroid in guinea-pigs under light sodium pentobarbitone anaesthesia. In normal animals during the oestrous cycle, the MCR was 112\m=.\8 \ m=+-\ 7\m=.\0 (S.E.) 1 plasma/day/kg. In pregnant animals there was a sharp decrease in MCR between days 15 and 20, to 8\ m=. \ 3\ m=+-\ 0\ m=. \ 81/ day/kg. This low clearance rate was observed throughout the remainder of gestation. After parturition MCR returned slowly to non-pregnant levels, reaching 85 1/day/kg by day 12 post partum.The decrease in metabolic clearance rate occurred at the same time as the increase in plasma concentration of progesterone. This may be related to an increase in binding proteins with a high affinity for progesterone. The stimulus for the decrease in MCR in pregnancy is obscure but appears to depend on the presence of a viable conceptus. In the non-pregnant guineapig the MCR is not reduced by exogenous oestrogen, hysterectomy or hypophysectomy.

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“…Kenagy and Place (2000) found that lactating female yellow-pine chipmunks had significantly higher total cortisol concentrations than pregnant and mating females or post-lactation females. However, given that the CBG concentration increases markedly with pregnancy and lactation in rodents (e.g., Rosenthal et al 1969aRosenthal et al , 1969bWestphal 1971;McDonald et al 1988;Boonstra and Boag 1992; Fig. 2), lactating chipmunks may be well buffered from these high concentrations.…”

Section: Changes In Glucocorticoid Concentrationmentioning

confidence: 99%

“…Pregnancy and lactation cause a major increase in concentrations of corticosteroid and corticosteroid-binding globulin (the blood carrier protein for glucocorticoids) in a variety of rodent species (Rosenthal et al 1969a(Rosenthal et al , 1969bMcDonald et al 1988), and prenatal and postnatal maternal stresses may affect offspring fitness (e.g., Dahlof et al 1977;Herrenkohl 1979;Crump and Chevins 1989;Sachser and Kaiser 1996). Reproduction is particularly stressful, especially for males, often being associated with intense intrasexual competition, and in some species, with pronounced negative effects on survival.…”

Section: Introductionmentioning

confidence: 99%

Seasonal changes in glucocorticoid and testosterone concentrations in free-living arctic ground squirrels from the boreal forest of the Yukon

Boonstra¹,

Hubbs²,

Lacey³

et al. 2001

Can. J. Zool.

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We examined how glucocorticoid and testosterone concentrations changed from spring to summer by livetrapping free-living populations of arctic ground squirrels (Spermophilus parryii). The primary glucocorticoid was found to be cortisol, with corticosterone below measurable concentrations in most individuals. Livetrapping elicited a strong stress response in both sexes: breeding males and females trapped in spring had free cortisol concentrations 4 and 34 times, respectively, those of base-line animals. The maximum corticosteroid-binding capacity (MCBC) was unaffected by trapping and was about 3 times higher in breeding females than in breeding males. Over the active season, MCBC values were lowest in all male classes (juveniles, nonreproductive adults, and reproductive adults), being less than half those in all female classes; pregnant females had values approximately twice those of juvenile females. However, free cortisol concentrations were similar in all female classes and in juvenile males and about half those in adult males. Livetrapping increased testosterone concentrations in males over those found in samples from base-line males, and testosterone concentrations did not affect MCBC values. Testosterone concentrations in livetrapped animals differed significantly among male classes, with nonreproductive males maintaining concentrations 64% of those in breeding males and 10 times those in juveniles.Résumé : Nous avons examiné les variations des concentrations de glucocorticoïdes et de testostérone du printemps à l'été par piégeage d'animaux vivants dans des populations de Spermophiles arctiques (Spermophilus parryii) en nature. Le principal glucocorticoïde est le cortisol; la corticostérone est présente en quantité trop faible pour être décelée chez la plupart des individus. Le piégeage déclenche une forte réaction de stress chez les deux sexes; chez les individus reproducteurs, mâles et femelles, au printemps les animaux piégés avaient des concentrations de cortisol 4 et 34 fois plus élevées respectivement que les valeurs de base. La capacité maximale de liaison des corticostéroïdes (MCBC) n'a pas été affectée par le piégeage et était environ 3 fois plus élevée chez les femelles reproductrices que chez les mâles.

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Transcortin: A Corticosteroid-Binding Protein of Plasma. XI. Effects of Estrogens or Pregnancy in Guinea Pigs

Cited by 26 publications

References 0 publications

Placenta, transcortin, and localized immune response.

Placenta, transcortin, and localized immune response.

Changes in the Metabolic Clearance Rate of Progesterone in the Guinea-Pig

Seasonal changes in glucocorticoid and testosterone concentrations in free-living arctic ground squirrels from the boreal forest of the Yukon

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