Transcranial alternating current stimulation modulates spontaneous low frequency fluctuations as measured with fMRI

Cabral‐Calderín, Yuranny; Williams, Kathleen A.; Opitz, Alexander; Dechent, Peter; Wilke, Melanie

doi:10.1016/j.neuroimage.2016.07.005

Cited by 62 publications

(61 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A suitable frequency of gamma band tACS might be higher than that of our study (30 Hz) because Cabral-Calderin et al . found effects of 40 Hz tACS 24 .…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Theta band transcranial alternating current stimulations modulates network behavior of dorsal anterior cingulate cortex

Onoda

Kawagoe

Zheng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Dorsal anterior cingulate cortex (dACC) is an important region in the processing of both cognition and affect. Recently, transcranial brain stimulation has been used to modulate cortical activity, but it is unclear whether this stimulation has a specific effect on dACC. Based on EEG evidence that frontal midline theta activity is generated in dACC, we hypothesized that transcranial alternating current stimulation (tACS) with theta band frequency would modulate neural networks including dACC. In this study, we examined the effects of theta band tACS on functional networks and emotional state. Graph theory analysis for resting-state functional MRI data revealed that theta band tACS decreased functional integration and hub capacity in dACC, and the attenuation of dACC network function was associated with emotional state change. Overall, these results demonstrate that theta band stimulation can modulate dACC.

show abstract

“…A suitable frequency of gamma band tACS might be higher than that of our study (30 Hz) because Cabral-Calderin et al . found effects of 40 Hz tACS 24 .…”

Section: Discussionmentioning

confidence: 95%

“…A recent study of Cabral-Calderin et al ., which examined the effects of alpha and gamma band tACS (Cz/Oz and P5/P6) on resting-state networks, also reported frequency-dependent manner 24 . Their finding was that alpha band tACS increased functional connectivity while gamma band tACS decreased it.…”

Section: Discussionmentioning

confidence: 99%

Theta band transcranial alternating current stimulations modulates network behavior of dorsal anterior cingulate cortex

Onoda

Kawagoe

Zheng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Future clinical trials using tACS in generalized epilepsy potentially need to use frequencies higher than 10 Hz to modulate functional connectivity between the stimulated area and more distant but anatomically and functionally connected regions (32). Also, choosing the stimulation intensity is also a key consideration during tACS studies (33).…”

Section: Discussionmentioning

confidence: 99%

Transcranial Alternating Current Stimulation: A Potential Risk for Genetic Generalized Epilepsy Patients (Study Case)

et al. 2016

View full text Add to dashboard Cite

Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoclonic epilepsy to 3 antiepileptic’s drugs characterized by 4 myoclonic and 20 absence seizures monthly. She received tACS at 1 mA at 3 Hz pulse train during 60 min over Fp1–Fp2 (10–20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device® (Natus Medical Incorporated, Middleton, WI, USA). At the 1-month follow-up, she reported a 75% increase in seizures frequency (only myoclonic and tonic–clonic events) and developed a 24-h myoclonic status epilepticus that resolved with oral clonazepam and intravenous valproate. At the 2-month follow-up, the patient reported a 15-day seizure-free period.

show abstract

“…Large variability in tES-outcome has been shown within and across studies. This variability is likely to be explained by the large number of factors influencing outcome (Fertonani and Miniussi, 2016), including current strength/density (Teo et al, 2011; Moos et al, 2012; Bastani and Jaberzadeh, 2013; Batsikadze et al, 2013; Hoy et al, 2013; Benwell et al, 2015; Ho et al, 2016), electrode montage (Moliadze et al, 2010; Sehm et al, 2013; Scheldrup et al, 2014; Mehta et al, 2015), stimulation duration (Nitsche and Paulus, 2000; Stagg and Nitsche, 2011), stimulation frequency (Kanai et al, 2010; Feurra et al, 2011; Brignani et al, 2013; Wach et al, 2013; Cabral-Calderin et al, 2016), timing of stimulation relative to task engagement (Pirulli et al, 2013; Scheldrup et al, 2014; Bortoletto et al, 2015; Cabral-Calderin et al, 2016), baseline trait/task performance levels of participants (Dockery et al, 2009; Tseng et al, 2012; Hsu et al, 2014; Sarkar et al, 2014; Benwell et al, 2015; Learmonth et al, 2015; Li et al, 2015b; London and Slagter, 2015), task demands (Li et al, 2015a; Roe et al, 2016) and the initial excitatory/oscillatory state of the stimulated region (Feurra et al, 2013). In addition to the difficulty of understanding all of the potential contributors to tES outcome, its effects tend to be relatively small and difficult to replicate (Walsh, 2013).…”

Section: Introductionmentioning

confidence: 99%

Inconsistent Effects of Parietal α-tACS on Pseudoneglect across Two Experiments: A Failed Internal Replication

et al. 2017

View full text Add to dashboard Cite

Transcranial electrical stimulation (tES) is being investigated as an experimental and clinical interventional technique in human participants. While promising, important limitations have been identified, including weak effect sizes and high inter- and intra-individual variability of outcomes. Here, we compared two “inhibitory” tES-techniques with supposedly different mechanisms of action as to their effects on performance in a visuospatial attention task, and report on a direct replication attempt. In two experiments, 2 × 20 healthy participants underwent tES in three separate sessions testing different protocols (10 min stimulation each) with a montage targeting right parietal cortex (right parietal–left frontal, electrode-sizes: 3cm × 3cm–7 cm × 5 cm), while performing a perceptual line bisection (landmark) task. The tES-protocols were compared as to their ability to modulate pseudoneglect (thought to be under right hemispheric control). In experiment 1, sham-tES was compared to transcranial alternating current stimulation at alpha frequency (10 Hz; α-tACS) (expected to entrain “inhibitory” alpha oscillations) and to cathodal transcranial direct current stimulation (c-tDCS) (shown to suppress neuronal spiking activity). In experiment 2, we attempted to replicate the findings of experiment 1, and establish frequency-specificity by adding a 45 Hz-tACS condition to α-tACS and sham. In experiment 1, right parietal α-tACS led to the expected changes in spatial attention bias, namely a rightward shift in subjective midpoint estimation (relative to sham). However, this was not confirmed in experiment 2 and in the complete sample. Right parietal c-tDCS and 45 Hz-tACS had no effect. These results highlight the importance of replication studies, adequate statistical power and optimizing tES-interventions for establishing the robustness and reliability of electrical stimulation effects, and best practice.

show abstract

Transcranial alternating current stimulation modulates spontaneous low frequency fluctuations as measured with fMRI

Cited by 62 publications

References 88 publications

Theta band transcranial alternating current stimulations modulates network behavior of dorsal anterior cingulate cortex

Theta band transcranial alternating current stimulations modulates network behavior of dorsal anterior cingulate cortex

Transcranial Alternating Current Stimulation: A Potential Risk for Genetic Generalized Epilepsy Patients (Study Case)

Inconsistent Effects of Parietal α-tACS on Pseudoneglect across Two Experiments: A Failed Internal Replication

Contact Info

Product

Resources

About