Transcranial Bioimpedance Measurement as a Non-invasive Estimate of Intracranial Pressure

Hawthorne, Christopher; Shaw, Martin; Piper, Ian; Moss, Laura; Kinsella, John

doi:10.1007/978-3-319-65798-1_19

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…Because the penetrability of nearinfrared light on human tissues is very weak, especially the skull, the detection sensitivity of the lesions in the deeper position of the brain is significantly reduced [25]. Bioelectrical impedance technology determines whether the ICP is increased by injecting current into the skull from the skull surface through electrodes and measuring the change in boundary potential [26]. However, in practice, it is difficult to guarantee the electrical contact effect between the electrode and the scalp.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive real-time assessment of intracranial pressure after traumatic brain injury based on electromagnetic coupling phase sensing technology

Zhao

et al. 2021

BMC Neurol

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Background To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase shift (ECPS) test system and conducted a comparison with invasive ICP. Methods TBI rabbits’ model were all synchronously monitored for 24 h by ECPS testing and invasive ICP. We investigated the abilities of the ECPS to detect targeted ICP by feature extraction and traditional classification decision algorithms. Results The ECPS showed an overall downward trend with a variation range of − 13.370 ± 2.245° as ICP rose from 11.450 ± 0.510 mmHg to 38.750 ± 4.064 mmHg, but its change rate gradually declined. It was greater than 1.5°/h during the first 6 h, then decreased to 0.5°/h and finally reached the minimum of 0.14°/h. Nonlinear regression analysis results illustrated that both the ECPS and its change rate decrease with increasing ICP post-TBI. When used as a recognition feature, the ability (area under the receiver operating characteristic curve, AUCs) of the ECPS to detect ICP ≥ 20 mmHg was 0.88 ± 0.01 based on the optimized adaptive boosting model, reaching the advanced level of current noninvasive ICP assessment methods. Conclusions The ECPS has the potential to be used for noninvasive continuous monitoring of elevated ICP post-TBI.

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Section: Discussionmentioning

confidence: 99%

Noninvasive real-time assessment of intracranial pressure after traumatic brain injury based on electromagnetic coupling phase sensing technology

Zhao

et al. 2021

BMC Neurol

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“…Although TCBI changes could be detected in babies that suffered intra-partum hypoxia, increased TCBI could not be used to predict neurological outcome (Lingwood et al 2009). In a small trial involving 10 patients, no significant relationship could be found between TCBI and invasively measured ICP (Hawthorne et al 2018). Lingwood and colleagues considered a baseline measurement to be important in assessing TCBI changes in piglets undergoing a hypoxic insult (Lingwood et al 2003).…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Transcranial bioimpedance measurement in horses: a pilot study

Gregson

Shaw

Piper

et al. 2019

Veterinary Anaesthesia and Analgesia

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“…An automatic detection algorithm was developed for ICP waveform analysis based on a similar observation as REG pulse wave distortion described here [41]. The relationship between non-invasive multi-frequency transcranial impedance measurements of the brain and skull and ICP in TBI patients in a previous study resulted in no correlation [42]. This type of measurement does not record the pulse wave.…”

Section: Icp and Regmentioning

confidence: 99%

Noninvasive Neuromonitoring with Rheoencephalography: A Case Report

Cannizzaro

Iwuchukwu

Rahaman

et al. 2022

Preprint

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Purpose Cerebral blood flow (CBF) autoregulation (AR) can be monitored using invasive modalities, such as intracranial pressure (ICP) and arterial blood pressure (ABP) to calculate the CBF AR index (PRx). Monitoring PRx can reduce the extent of secondary brain damage in patients. Rheoencephalography (REG) is an FDA-approved non-invasive method to measure CBF. REGx, a CBF AR index, is calculated from REG and arm bioimpedance pulse waves. Our goal was to test REG for neuromonitoring. Methods 28 measurement sessions were performed on 13 neurocritical care patients. REG/arm bioimpedance waveforms were recorded on a laptop using a bioimpedance amplifier and custom-built software. The same program was used for offline data processing. Results Case #1: The patient’s mean REGx increased from − 0.08 on the first day to 0.44 on the second day, indicating worsening intracranial compliance (ICC) (P < 0.0001, CI 0.46–0.58). Glasgow Coma Scale (GCS) was 5 on both days. Case #2: REGx decreased from 0.32 on the first recording to 0.07 on the last (P = 0.0003, CI-0.38 to -0.12). GCS was 7 and 14, respectively. Case #3: Within a 36-minute recording, REGx decreased from 0.56 to -0.37 (P < 0.0001, 95%, CI: -1.10 to -0.76). Central venous pressure changed from 14 to 9 mmHg. REG pulse wave morphology changed from poor ICC to good ICC morphology. Conclusion Bioimpedance recording made it possible to quantify the active/passive status of CBF AR, indicate the worsening of ICC, and present it in real-time. REGx can be a suitable, non-invasive alternative to PRx for use in head-injured patients.

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Transcranial Bioimpedance Measurement as a Non-invasive Estimate of Intracranial Pressure

Abstract: These pilot results confirm some degree of relationship between TCB parameters and invasively measured ICP. The magnitude of this relationship is small and, on the basis of the current study, TCB is unlikely to provide a clinically useful estimate of ICP in patients admitted with TBI.

Cited by 12 publications

References 7 publications

Noninvasive real-time assessment of intracranial pressure after traumatic brain injury based on electromagnetic coupling phase sensing technology

Noninvasive real-time assessment of intracranial pressure after traumatic brain injury based on electromagnetic coupling phase sensing technology

Transcranial bioimpedance measurement in horses: a pilot study

Noninvasive Neuromonitoring with Rheoencephalography: A Case Report

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