Transcranial Brain Stimulation to Treat Aphasia: A Clinical Perspective

Fridriksson, Julius; Hubbard, Heidi; Hudspeth, Sarah Grace

doi:10.1055/s-0032-1320039

Cited by 15 publications

(14 citation statements)

References 84 publications

(263 reference statements)

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“…Results showed that 3 weeks of intensive SLT enhanced verbal communication in patients following SRA. Thus, while SLT can lead to improvements, Fridriksson et al [7] also observed that progress is often very slow, especially in the chronic stage.…”

Section: Introductionmentioning

confidence: 99%

Further Evidence of the Positive Influence of Repetitive Transcranial Magnetic Stimulation on Speech and Language in Patients with Aphasia after Stroke: Results from a Double-Blind Intervention with Sham Condition

et al. 2017

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Background: After a stroke, up to 20% of patients suffer from aphasia. The preferred treatment for stroke-related aphasia (SRA) is regular speech and language training (SLT). In the present study, we investigated to what extent adjuvant repetitive transcranial magnetic stimulation (rTMS) might enhance recovery. While there is growing evidence of the positive effect of adjuvant rTMS on aphasia, no study has yet been based on an Iranian sample. Method: A total of 12 patients (mean age: 55 years; right-handed; 7 women) underwent treatment for SRA 1 month after stroke. The standard treatment consisted of regular 45-min SLT sessions 5 times a week for 2 consecutive weeks. Additionally, patients were randomly assigned either to adjuvant rTMS (5 times a week for 30 min) or to a sham condition (5 times a week for 30 min). At baseline and after 2 weeks of intervention, the degree of aphasia was assessed with the Farsi version of the Western Aphasia Battery. rTMS was applied to the inferior posterior frontal gyrus of the right hemisphere. Results: Speech and language improved over time, but more so in the rTMS than in the sham condition. Large effect sizes were observed for content, fluency, and the aphasia quotient; medium effect sizes were observed for command comprehension and repetition, while effect sizes were small for auditory comprehension and naming. Conclusions: Among patients with SRA, compared to a sham condition, adjuvant rTMS improved speech and language skills. The present results add to the accumulating evidence that rTMS as a neuromodulation technique has the capacity to enhance the effect of conventional SLT.

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Section: Introductionmentioning

confidence: 99%

Further Evidence of the Positive Influence of Repetitive Transcranial Magnetic Stimulation on Speech and Language in Patients with Aphasia after Stroke: Results from a Double-Blind Intervention with Sham Condition

et al. 2017

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“…The clinical importance of tDCS requires establishing therapy generalization and maintenance of treatment in clinical populations. Two research groups have provided relevant evidence: Fridriksson’s group in spoken naming remediation in post-stroke aphasia 70, 75, 76 and Boggio’s group in associative memory remediation in AD 77–79 . After five consecutive stimulations, therapy gains were found to last up to four weeks 62, 75, 77, 80 .…”

Section: Introductionmentioning

confidence: 99%

Treatment of Primary Progressive Aphasia

Tippett

Hillis

Tsapkini

2015

Curr Treat Options Neurol

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Primary progressive aphasia (PPA) is a neurodegenerative disease that primarily affects language functions and often begins in the fifth or sixth decade of life. The devastating effects on work and home life call for the investigation of treatment alternatives. In this paper, we present a review of the literature on treatment approaches for this neurodegenerative disease. We also present new data from two intervention studies we have conducted, a behavioral one and a neuromodulatory one using transcranial direct current stimulation (tDCS) combined with written production intervention. We show that speech-language intervention improves language outcomes in individuals with PPA; and especially in the short term, tDCS augments generalization and maintenance of positive language outcomes. We also outline current issues and challenges in intervention approaches in PPA.

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“…The potential of tDCS for improving performance in naming tasks has been repeatedly demonstrated (e.g. Holland et al, 2011; Monti et al, 2013) and there are already several comprehensive reviews of this literature (Fridriksson, Hubbard, & Hudspeth, 2012; Málly, 2013). In this review, we will instead concentrate on those studies that tested the impact of tES on speech perception or comprehension.…”

Section: Historical Backgroundmentioning

confidence: 97%

Transcranial electric stimulation for the investigation of speech perception and comprehension

Zoefel

Davis

2016

Language, Cognition and Neuroscience

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Transcranial electric stimulation (tES), comprising transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), involves applying weak electrical current to the scalp, which can be used to modulate membrane potentials and thereby modify neural activity. Critically, behavioural or perceptual consequences of this modulation provide evidence for a causal role of neural activity in the stimulated brain region for the observed outcome. We present tES as a tool for the investigation of which neural responses are necessary for successful speech perception and comprehension. We summarise existing studies, along with challenges that need to be overcome, potential solutions, and future directions. We conclude that, although standardised stimulation parameters still need to be established, tES is a promising tool for revealing the neural basis of speech processing. Future research can use this method to explore the causal role of brain regions and neural processes for the perception and comprehension of speech.

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Transcranial Brain Stimulation to Treat Aphasia: A Clinical Perspective

Cited by 15 publications

References 84 publications

Further Evidence of the Positive Influence of Repetitive Transcranial Magnetic Stimulation on Speech and Language in Patients with Aphasia after Stroke: Results from a Double-Blind Intervention with Sham Condition

Further Evidence of the Positive Influence of Repetitive Transcranial Magnetic Stimulation on Speech and Language in Patients with Aphasia after Stroke: Results from a Double-Blind Intervention with Sham Condition

Treatment of Primary Progressive Aphasia

Transcranial electric stimulation for the investigation of speech perception and comprehension

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