Transcranial color Doppler sonography of basal cerebral arteries in 182 healthy subjects: age and sex variability and normal reference values for blood flow parameters.

Krejza, Jarosław; Mariak, Zenon; Walecki, Jerzy; Szydlik, Piotr; Lewko, Jolanta; Ustymowicz, Andrzej

doi:10.2214/ajr.172.1.9888770

Cited by 172 publications

(124 citation statements)

References 18 publications

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“…While increases in delta and theta EEG activity accompany larger deficits in cerebral perfusion, subtle deficits in perfusion were accompanied by decreases in alpha and beta activity (Jordan, 2004) as we have observed in the present study. In a similar sample of young marijuana abusers, cerebral resistance measured by the transcranial Doppler parameter, Pulsatilty Index (PI), was similar to that observed in healthy individuals over 60 years of age (Herning et al, 2005;Krejza et al 1999). Cerebral resistance as measured by PI remained elevated over the month of monitored abstinence in the heavy marijuana abusers (Herning et al, 2005).…”

Section: Discussionmentioning

confidence: 57%

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

Herning

Better

Cadet

2008

Clinical Neurophysiology

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Objective-Marijuana abuse is associated with neurological changes including increases in frontal EEG alpha during abstinence. Research is needed to assess to what extent these EEG patterns are indicative of cerebral perfusion deficits.Methods-We recorded the resting eyes closed EEG of 75 abstinent marijuana users and 33 control subjects. Fifty-six marijuana users used marijuana for less than eight years and 19 used for eight years or more. The EEG evaluation occurred within 72 hours of admission to an inpatient unit. Fiftynine marijuana users remained abstinent for a month and were tested twice. Supplemental psychological and physiological data were also collected.Results-Log alpha2 and beta2 power at posterior sites were significantly lower for the marijuana abusers that used eight years or more than the other marijuana abusers and the control subjects. These EEG changes continued for the month of abstinence. The marijuana users who used marijuana for more than eight years, also, had lower heart rates and thyroid function (T4) compared to the other marijuana users and the control subjects.Conclusions-Chronic marijuana use was also associated with reduced EEG power in alpha and beta bands at posterior sites. These reductions in EEG power appear to be related to cerebral perfusion deficits and/or thyroid function in marijuana abusers.Significance-Our results suggest EEG, cerebral blood flow velocity, cardiovascular and thyroid function alterations in marijuana abuser with an extended period of use. These alterations reflect under arousal in these systems.

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Section: Discussionmentioning

confidence: 57%

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

Herning

Better

Cadet

2008

Clinical Neurophysiology

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“…Several investigators have previously described sex-related differences in CBF in humans (Grolimund, Seiler 1988, Vriens et al 1989, Marinoni et al 1998, Muller, Schimrigk 1994, Krejza et al 1999, Deegan et al 2009), although in most cases, the number of subjects tended to be relatively small and only a few studies reported on CBFV (Deegan et al 2009). Most studies report higher mean blood flow velocities in females over males; however it is questioned whether this difference is limited to specific ages (Vriens et al 1989, Krejza et al 1999).…”

Section: Influence Of Sexmentioning

confidence: 99%

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

et al. 2016

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Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex.Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15-minute stabilisation, and a 5-minute baseline recording.Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males.Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes. Key wordsCerebral haemodynamics, cerebral autoregulation, ageing, sex differences, cerebral blood

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“…In the brain, the number of endothelial cells is very similar to that of neurons (GarciaAmado and Prensa 2012) and nearly every neuron is supplied by its own capillary, with an average distance of 8-20 μm between the neuron and the microvessels. Importantly, there is strong evidence that aging is associated with a decline in cerebral capillary density ("microvascular rarefaction") and that decreases in cerebromicrovascular density contribute to the agerelated decline in regional cerebral blood flow (Mitschelen et al 2009;Riddle et al 2003;Khan et al 2001;Lynch et al 1999;Sonntag et al 1997;Martin et al 1991;Moeller et al 1996;Farkas and Luiten 2001;Kawamura et al 1993;Krejza et al 1999;Schultz et al 1999;Bentourkia et al 2000;Hagstadius and Risberg 1989;Pagani et al 2002). The resulting mismatch between energy supply and demand has been causally linked to significant cognitive impairment (reviewed in Sonntag et al 1997;Ingraham et al 2008;Sonntag et al 2000;Warrington et al 2011;Warrington et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini

Tucsek

Valcarcel‐Ares

et al. 2016

AGE

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Strong epidemiological and experimental evidence indicate that both age and hypertension lead to significant functional and structural impairment of the cerebral microcirculation, predisposing to the development of vascular cognitive impairment (VCI) and Alzheimer's disease. Preclinical studies establish a causal link between cognitive decline and microvascular rarefaction in the hippocampus, an area of brain important for learning and memory. Age-related decline in circulating IGF-1 levels results in functional impairment of the cerebral microvessels; however, the mechanistic role of IGF-1 deficiency in impaired hippocampal microvascularization remains elusive. The present study was designed to characterize the additive/synergistic effects of IGF-1 deficiency and hypertension on microvascular density and expression of genes involved in angiogenesis and microvascular AGE (2016) 38:273-289

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Transcranial color Doppler sonography of basal cerebral arteries in 182 healthy subjects: age and sex variability and normal reference values for blood flow parameters.

Cited by 172 publications

References 18 publications

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

EEG of chronic marijuana users during abstinence: Relationship to years of marijuana use, cerebral blood flow and thyroid function

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

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