Transcranial direct current stimulation during treadmill training in children with cerebral palsy: A randomized controlled double-blind clinical trial

Grecco, Luanda André Collange; Duarte, Natália de Almeida Carvalho; Mendonça, Mariana E.; Cimolin, Verônica; Galli, Manuela; Fregni, Felipe; Oliveira, Cláudia Santos

doi:10.1016/j.ridd.2014.07.030

Cited by 91 publications

(132 citation statements)

References 39 publications

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“…The impact of tDCS on symptoms of cerebral palsy and dystonia has been investigated by a few studies in children and adolescents. Most published studies report some clinical improvements without important adverse effects (Grecco et al, 2013(Grecco et al, , 2014aYoung et al, 2013Young et al, , 2014Duarte et al, 2014;Gillick et al, 2014Gillick et al, , 2015aCollange Grecco et al, 2015), with one exception that will be mentioned in the discussion section (Ekici, 2015). A null effect was also reported in one case ( Bhanpuri et al, 2015).…”

Section: Cerebral Palsy and Dystoniamentioning

confidence: 98%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2016

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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Section: Cerebral Palsy and Dystoniamentioning

confidence: 98%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2016

Reviews in the Neurosciences

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“…47 These findings led to an investigation in which children with spastic diplegia underwent treadmill training and concurrent anodal tDCS over the primary motor cortex contralateral to the dominant side of the body. 48 Some improvements in gait variables and functional mobility were reported, and were maintained for at least 1 month. 48 A similar approach is paired associative stimulation, in which peripheral sensory stimulation is paired with TMS of the motor cortex; this approach is thought to induce long-term potentiation in sensorimotor networks.…”

Section: Introductionmentioning

confidence: 94%

Rehabilitation and neuroplasticity in children with unilateral cerebral palsy

2015

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Cerebral palsy is a childhood-onset, lifelong neurological disorder that primarily impairs motor function. Unilateral cerebral palsy (UCP), which impairs use of one hand and perturbs bimanual co-ordination, is the most common form of the condition. The main contemporary upper limb rehabilitation strategies for UCP are constraint-induced movement therapy and bimanual intensive therapy. In this Review, we outline the factors that are crucial to the success of motor rehabilitation in children with UCP, including the dose of training, the relevance of training to daily life, the suitability of training to the age and goals of the child, and the ability of the child to maintain close attention to the tasks. Emerging evidence suggests that the first 2 years of life are a critical period during which interventions for UCP could be more effective than in later life. Abnormal brain organization in UCP, and the effects of development on rehabilitation, must also be understood to develop new effective interventions. Therefore, we also consider neuroimaging methods that can provide insight into the neurobiology of UCP and how the condition responds to existing therapies. We discuss how these methods could shape future rehabilitative strategies based on the neurobiology of UCP and the therapy-induced changes seen in the brain.

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“…(12,13) The development of new therapeutic techniques in physical rehabilitation programs is important to enhancing functional outcomes. (14) Transcranial direct current stimulation (tDCS) is a promising, easily administered, well-tolerated technique involving inexpensive equipment and minimal adverse effects. This method stimulates the cortex with a direct, low-intensity (1 to 2 mA) electric current and two electrodes.…”

Section: Introductionmentioning

confidence: 99%

Treadmill training combined with transcranial direct current stimulation over the primary motor cortex in a child with cerebral palsy and hydrocephalus: A case report.

Rezende¹,

Duarte²,

Grecco³

et al. 2014

mtprehabjournal

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Transcranial direct current stimulation during treadmill training in children with cerebral palsy: A randomized controlled double-blind clinical trial

Cited by 91 publications

References 39 publications

Applications of transcranial direct current stimulation in children and pediatrics

Applications of transcranial direct current stimulation in children and pediatrics

Rehabilitation and neuroplasticity in children with unilateral cerebral palsy

Treadmill training combined with transcranial direct current stimulation over the primary motor cortex in a child with cerebral palsy and hydrocephalus: A case report.

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