Transcranial direct current stimulation for memory enhancement: from clinical research to animal models

Bennabi, Djamila; Pedron, Solã ̈Ne; Haffen, Emmanuel; Monnin, Julie; Peterschmitt, Yvan; Waes, Vincent Van

doi:10.3389/fnsys.2014.00159

Cited by 76 publications

(63 citation statements)

References 66 publications

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“…However, the results of that particular experiment have not been peer-reviewed yet, and questions may be raised about the generalizability of results from cadaver studies to living human beings. Recently, several animal studies have been performed to gain more insight into how tES modulates neural function (Bennabi et al, 2014). Translational studies may help to shed light on the exact working mechanisms of tES in the future.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Electrical Stimulation to Enhance Cognitive Performance of Healthy Minors: A Complex Governance Challenge

Schuijer

Jong

Kupper

et al. 2017

Front. Hum. Neurosci.

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An increasing number of healthy adolescents are consuming products that can enhance their cognitive performance in educational settings. Currently, the use of pharmaceuticals is the most widely discussed enhancement method in the literature, but new evidence suggests that other methods based on Transcranial Electrical Stimulation (tES) also have potential as cognitive enhancer. Just like pharmaceutical enhancers, the availability and education-related use of tES-devices raise a broad range of ethical, legal, and societal issues that need to be addressed by policy-makers. Few studies, however, have specifically explored these issues in relation to child wellbeing. In this narrative review with systematic search, we describe the issues for child wellbeing that could arise from the availability and education-related use of tES-based enhancers by healthy minors. We demonstrate that the issues form a complex web of uncertainties and concerns, which are mainly incited by two factors. First is the high level of factual uncertainty due to gaps in empirical evidence about the exact working mechanisms and efficacy of tES. Moreover, a lack of insight into the technique’s (long-term) effects on healthy developing brains, and uncertainties about potential cognitive trade-offs have fueled concerns about the technique’s safety and impact. The second factor that contributes to the complexity of issues is the presence of moral diversity in our society. Different opinions exist on whether a certain enhancement effect would be desirable and whether potential risks would be acceptable. These opinions depend on one’s moral perspective, and the way one interprets and weights values such as the child’s autonomy and authenticity. The challenge for proper governance resides in the design of an appropriate framework that is capable of balancing the different moral perspectives in society, while recognizing the uncertainties that still exist. We therefore argue for a responsible innovation approach, which encourages an adaptive attitude toward emerging knowledge and dynamic societal values, to deal with the identified issues regarding tES-based enhancement appropriately.

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Section: Introductionmentioning

confidence: 99%

Transcranial Electrical Stimulation to Enhance Cognitive Performance of Healthy Minors: A Complex Governance Challenge

Schuijer

Jong

Kupper

et al. 2017

Front. Hum. Neurosci.

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“…TDCS effects on underlying cortical excitability (Nitsche and Paulus, 2000; Nitsche et al, 2005) have led to measurable changes in behavior following stimulation over lateral prefrontal (Gladwin et al, 2012; Leite et al, 2013; Minati et al, 2012; Nelson et al, 2014; Pope et al, 2015) or posterior parietal cortex (Berryhill & Jones, 2012; Manenti, Brambilla, Petesi, Ferrari, & Cotelli, 2013; Moos, Vossel, Weidner, Sparing, & Fink, 2012; Pergolizzi & Chua, 2016, 2015; Pisoni et al, 2015). Of particular interest here is that tDCS has been useful for investigating the causal role of various neocortical regions in memory processes (Bennabi et al, 2014; Brasil-Neto, 2012; Manenti et al, 2012). For example, administration of bilateral tDCS over lateral parietal cortex during retrieval resulted in increased false recognition using a paradigm known to elicit high rates of false recognition (Pergolizzi & Chua, 2015), and decreased false recognition on an item and source memory paradigm (Pergolizzi and Chua, 2016), consistent with task dependent changes in decision bias.…”

Section: Introductionmentioning

confidence: 99%

Increased contextual cue utilization with tDCS over the prefrontal cortex during a recognition task

Pergolizzi

Chua

2017

Brain Research

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The precise role of the prefrontal and posterior parietal cortices in recognition performance remains controversial, with questions about whether these regions contribute to recognition via the availability of mnemonic evidence or via decision biases and retrieval orientation. Here we used an explicit memory cueing paradigm, whereby external cues probabilistically predict upcoming memoranda as old or new, in our case with 75% validity, and these cues affect recognition decision biases in the direction of the cue. The present study applied bilateral transcranial direct current stimulation (tDCS) over prefrontal or posterior parietal cortex, or sham tDCS, to test the causal role of these regions in recognition accuracy or decision biasing. Participants who received tDCS over prefrontal cortex showed increased cue utilization compared to tDCS over posterior parietal cortex and sham tDCS, suggesting that the prefrontal cortex is involved in processes that contribute to decision biases in memory.

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“…Berlim et al, 2013; Brunoni et al, 2012; Kuo et al, 2014), memory disorders ( e.g. Bennabi et al, 2014) and addiction (Feil and Zangen, 2010). For example, studies found that repeated tDCS over the prefrontal cortex decreased craving for, and the consumption of, cigarettes (Boggio et al, 2009; Fecteau et al, 2014; Fregni et al, 2008) and alcohol (Boggio et al, 2008; Klauss et al, 2014) in chronic users.…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits

et al. 2016

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Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability. This technique is a promising emerging tool to treat several neuropathologies, including addiction. We have previously shown in mice that repeated tDCS normalizes pathological behaviors associated with chronic nicotine exposure. Here, we evaluated, in adult female mice, the impact of tDCS on cocaine-induced behavior and gene regulation in corticostriatal circuits implicated in psychostimulant addiction. Anodal tDCS was applied transcranially over the frontal cortex. Three weeks after repeated tDCS, we investigated the induction of a gene expression marker (Zif268) by cocaine (25 mg/kg) in 26 cortical and 23 striatal regions using in situ hybridization histochemistry. We also assessed place preference conditioning by cocaine (5, 10, and 25 mg/kg). tDCS pretreatment increased basal expression and attenuated cocaine (25 mg/kg)-induced expression of Zif268 in specific corticostriatal circuits. Cocaine-induced locomotor activation (25 mg/kg) and place preference conditioning (5 and 25 mg/kg) were also reduced. These results demonstrate that tDCS can attenuate molecular and behavioral responses to cocaine for several weeks. Together, our findings provide pre-clinical evidence that such electrical brain stimulation may be useful to modify the psychostimulant addiction risk.

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Transcranial direct current stimulation for memory enhancement: from clinical research to animal models

Cited by 76 publications

References 66 publications

Transcranial Electrical Stimulation to Enhance Cognitive Performance of Healthy Minors: A Complex Governance Challenge

Transcranial Electrical Stimulation to Enhance Cognitive Performance of Healthy Minors: A Complex Governance Challenge

Increased contextual cue utilization with tDCS over the prefrontal cortex during a recognition task

Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits

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