Transcranial Direct Current Stimulation in Substance Use Disorders

Lupi, M.; Martinotti, Giovanni; Santacroce, Rita; Cinosi, Eduardo; Carlucci, Melissa; Marini, Stefano; Acciavatti, T.; Giannantonio, Massimo Di

doi:10.1097/yct.0000000000000401

Cited by 79 publications

(52 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DLPFC findings are particularly important given the role of this region in cognitive control and other executive functions that contribute to drinking decisions (Niendam et al 2012). The DLPFC is also commonly targeted via neuromodulation interventions using non-invasive brain stimulation techniques (e.g., Boggio et al, 2008;Coles, Kozak, & George, 2018;Lupi et al, 2017;Mishra, Nizamie, Das, & Praharaj, 2010) and cognitive interventions such as executive function or working memory training (Duda and Sweet, In Press;Olesen, Westerberg and Klingberg, 2004;Takeuchi et al, 2011). Furthermore, by demonstrating that no regions are associated with alcohol use beyond their shared associations with the DLPFC, the current study highlights the importance of DLPFC in understanding how alcohol use is linked with the brain.…”

Section: Discussionmentioning

confidence: 99%

Associations between drinking and cortical thickness in young adult drinkers: Findings from the Human Connectome Project

Morris¹,

Syan²,

Petker³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background. Previous neuroimaging studies examining relations between alcohol misuse and cortical thickness have revealed that increased drinking quantity and alcohol use disorder severity are associated with thinner cortex. Although conflicting regional effects are often observed, associations are generally localized to frontal regions (e.g., dorsolateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG), and anterior cingulate cortex), with parietal and temporal cortex also implicated in some studies. Inconsistent findings may be attributed to methodological differences, modest sample sizes, and limited consideration of sex differences.Method. This study examined neuroanatomical correlates of drinking quantity and heavy episodic drinking in a large sample of young adults (N=706; M age = 28.8; 51% female) using magnetic resonance imaging data from the Human Connectome Project (HCP). Results.Hierarchical linear regression models (controlling for age, sex, education, income, smoking, drug use, twin status, and intracranial volume) revealed significant inverse associations between drinks/week and frequency of heavy drinking and cortical thickness in a majority of regions examined. The largest effect sizes were found for frontal regions (i.e., DLPFC, IFG, and the precentral gyrus). Follow-up regression models revealed that the left DLPFC was uniquely associated with both drinking variables. Sex differences were also observed, with significant effects largely specific to men. Conclusions. This study adds to the understanding of brain correlates of alcohol use in a large, gender-balanced sample of young adults who exhibit a range of drinking levels. Although the cross-sectional methodology used in the present study preclude causal inferences, these findings provide a foundation for rigorous hypothesis testing in future longitudinal investigations.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations between drinking and cortical thickness in young adult drinkers: Findings from the Human Connectome Project

Morris¹,

Syan²,

Petker³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Growing attention has been given to noninvasive brain stimulation techniques in addictive disorders as novel therapeutic modalities. Noninvasive brain stimulation techniques of repeated transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have demonstrated significant effects in controlling of substance or food cravings [87,88].…”

Section: Neuromodulationmentioning

confidence: 99%

Prevention Strategies and Interventions for Internet Use Disorders Due to Addictive Behaviors Based on an Integrative Conceptual Model

2019

View full text Add to dashboard Cite

Purpose of Review With increasing use of the Internet throughout our daily lives, Internet use disorders (IUDs) due to addictive behaviors are gaining recognition. As an umbrella term, IUD covers an array of online behaviors that are potentially addictive. The growing population of Internet and smartphone users also raised public health concerns over IUD in regard to adverse cognitive, developmental, psychosocial, and physical consequences. While scientific literature to date has tended to focus on specific forms of IUD such as gaming or pornography, confining our attention to only these specific areas may impede research on the combined effects of multiple online addictive behaviors-often the clinical reality in maladapted Internet use. Taking this broader approach may also facilitate prioritization in policymaking and more efficient allocation of public health and clinical resources. This paper discusses conceptual application of a public health model at the society level and an integrative model at the individual level in IUD intervention strategies. Current treatment modalities of IUD are also reviewed from a biopsychosocial perspective. Recent Findings We propose that the harms of IUD are mediated by (1) risky/harmful content, (2) excessive/maladaptive use, and (3) financial burden. Prevention strategies that reduce the potential negative effects of these mediators may be useful against IUD. Summary Prevention and intervention efforts against IUD should not only target the "host" (individual vulnerabilities) but also the "agent" (media-related risks) and "environment" risks to better address complexities in the phenomena. The current mainstream therapeutic modality is psychosocial intervention. Further studies on psychopharmacology and neuromodulation are needed to broaden our therapeutic options for IUD.tf

show abstract

“…Considerable evidence has demonstrated that modulating the activities of addiction-related brain areas is a promising strategy to control drug use and relapse [75]. Although there are various ways to modulate the activity of a specific brain area, such as random noise stimulation, ultrasound stimulation, electoral stimulation, and magnetic stimulation, recent research has been focusing on the latter two [76,77]. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are two of the best-studied approaches for treating drug addiction and other mental disorders [76][77][78][79].…”

Section: Brain Stimulationmentioning

confidence: 99%

“…Although there are various ways to modulate the activity of a specific brain area, such as random noise stimulation, ultrasound stimulation, electoral stimulation, and magnetic stimulation, recent research has been focusing on the latter two [76,77]. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are two of the best-studied approaches for treating drug addiction and other mental disorders [76][77][78][79]. Studies have shown that stimulating dorsal lateral PFC by TMS and tDCS were effective to reduce craving, improve cognition, and ameliorate the mood states in subjects using major drugs of abuse [76,80].…”

Section: Brain Stimulationmentioning

confidence: 99%

“…Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are two of the best-studied approaches for treating drug addiction and other mental disorders [76][77][78][79]. Studies have shown that stimulating dorsal lateral PFC by TMS and tDCS were effective to reduce craving, improve cognition, and ameliorate the mood states in subjects using major drugs of abuse [76,80]. Importantly, TMS and tDCS showed greater advantages than other invasive strategies including deep brain stimulation (DBS) that requires invasive electrodes to be implanted into the target brain areas [80].…”

Section: Brain Stimulationmentioning

confidence: 99%

See 1 more Smart Citation

Drug addiction: a curable mental disorder?

Liu

2018

Acta Pharmacol Sin

View full text Add to dashboard Cite

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain including the reward system (e.g., the mesocorticolimbic system), the anti-reward/stress system (e.g., the extended amygdala), and the central immune system, are involved in the development of drug addiction and relapse after withdrawal from drugs of abuse. Preclinical and clinical studies have demonstrated that it is promising to control drug addiction by pharmacologically targeting the addiction-related systems in the brain. Here we review the pharmacological targets within the dopamine system, glutamate system, trace amine system, antireward system, and central immune system, which are of clinical interests. Furthermore, we discuss other potential therapies, e.g., brain stimulation, behavioral treatments, and therapeutic gene modulation, which could be effective to treat drug addiction. We conclude that, although drug addiction is a complex disorder that involves complicated neural mechanisms and psychological processes, this mental disorder is treatable and may be curable by therapies such as gene modulation in the future.

show abstract

Transcranial Direct Current Stimulation in Substance Use Disorders

Cited by 79 publications

References 39 publications

Associations between drinking and cortical thickness in young adult drinkers: Findings from the Human Connectome Project

Associations between drinking and cortical thickness in young adult drinkers: Findings from the Human Connectome Project

Prevention Strategies and Interventions for Internet Use Disorders Due to Addictive Behaviors Based on an Integrative Conceptual Model

Drug addiction: a curable mental disorder?

Contact Info

Product

Resources

About