Transcranial direct current stimulation in mild cognitive impairment: methodology for a randomized controlled trial

Alencastro, Aline S; Pereira, Danilo Assis; Brasil‐Neto, Joaquim P.

doi:10.7287/peerj.preprints.1610v1

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Medications such as rivastigmine and donepezil have been tried for the treatment of MCI, but there are limitations in terms of their efficacy and safety [ 7 , 8 ]. Nonpharmaceutical treatments, such as transcranial magnetic stimulation, have been attempted as well [ 9 ], but there is currently no established treatment for MCI.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Auricular Acupuncture for Cognitive Impairment and Dementia: A Systematic Review

Kwon

Lee

Suh

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives To analyze the efficacy and safety of auricular acupuncture (AA) in patients with cognitive impairment and dementia. Methods Twelve electronic databases were searched for randomized controlled trials evaluating effects of AA in patients with cognitive impairment and/or dementia, from their inception to August 2017. The primary outcome was cognitive function, and secondary outcomes were self-care ability, quality of life, clinical efficacy rate, and incidences of adverse events. Results Nine studies were included, and five involving 677 participants were analyzed quantitatively. Compared with Western medications (WM), AA had mixed effects on cognitive functions (Mini-Mental State Examination [MMSE], mean difference [MD] 0.73, 95% confidence interval [CI] −0.02 to 1.48; Hierarchic Dementia Scale [HDS], MD 2.21, 95% CI 1.09 to 3.33); there was no significant improvement in the activities of daily living (ADL) score (MD 0.20, 95% CI −3.51 to 3.91) in patients with vascular dementia (VD). Compared to WM, AA combined with WM showed better clinical efficacy rate (risk ratio [RR] 1.42, 95% CI 1.06 to 1.91) in patients with VD; there was no significant improvement in cognitive functions (MMSE, MD 0.97, 95% CI −0.44 to 2.38; Montreal Cognitive Assessment [MoCA], MD 0.22, 95% CI −1.83 to 2.27) in patients with mild cognitive impairment (MCI). Compared to herbal medicine (HM), AA plus HM showed significant improvements in cognitive function (MMSE, MD 1.31, 95% CI 0.13 to 2.49) in patients with MCI and patients with vascular cognitive impairment, no dementia (VCIND) and in ADL score (MD −6.70, 95% CI −8.78 to −4.62) in patients with MCI. No adverse event associated with AA was reported. Conclusion The evidence reveals mixed efficacy of AA in patients with cognitive impairment and/or dementia. However, the results were inconclusive because of the small number and poor methodological quality of the included studies.

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Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Auricular Acupuncture for Cognitive Impairment and Dementia: A Systematic Review

Kwon

Lee

Suh

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

Transcranial direct current stimulation in mild cognitive impairment: methodology for a randomized controlled trial

Abstract: Background: Transcranial direct current stimulation (tDCS) is a non-invasive

Cited by 1 publication

References 15 publications

Efficacy and Safety of Auricular Acupuncture for Cognitive Impairment and Dementia: A Systematic Review

Efficacy and Safety of Auricular Acupuncture for Cognitive Impairment and Dementia: A Systematic Review

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