Transcranial direct current stimulation in psychiatric disorders

Tortella, Gabriel; Casati, Roberta; Aparicio, Luana V. M.; Mantovani, Antonio; Senço, Natasha Malo de; D’Urso, Giordano; Brunelin, Jérôme; Guarienti, Fabiana Amaral; Selingardi, Priscila Mara Lorencini; Muszkat, Débora; Pereira, Bruno; Valiengo, Leandro; Moffa, Adriano H.; Simis, Marcel; Borrione, Lucas; Brunoni, André R.

doi:10.5498/wjp.v5.i1.88

Cited by 138 publications

(89 citation statements)

References 134 publications

(165 reference statements)

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“…A number of techniques for therapeutic brain stimulation are entering clinical use for treatment-resistant psychiatric illnesses. These include deep brain stimulation (DBS; Lozano and Lipsman, 2013), repetitive transcranial magnetic stimulation (rTMS; Lefaucheur et al, 2014) and transcranial direct current stimulation (tDCS; Tortella et al, 2015). …”

Section: Targeting the Sn-cstc With Therapeutic Brain Stimulationmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

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The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the network’s associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. The SN’s cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of psychiatric illnesses and their available treatments. Functional imbalances within the SN loop appear to impair cognitive control, and specifically may impair self-regulation of cognition, behavior and emotion, thereby leading to symptoms of psychiatric illness. Furthermore, treating such psychiatric illnesses using invasive or non-invasive brain stimulation techniques appears to modulate SN cortical-subcortical loop integrity, and these effects may be central to the therapeutic mechanisms of brain stimulation treatments in many psychiatric illnesses. Here, we review clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED). We also review emergent therapeutic evidence that novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop, thereby restoring the capacity for cognitive control. Finally, we consider a series of promising directions for future investigations on the role of SN cortico-striatal-thalamic loop circuits in the pathophysiology and treatment of psychiatric disorders.

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Section: Targeting the Sn-cstc With Therapeutic Brain Stimulationmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

View full text Add to dashboard Cite

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“…While still in relatively early stages, tDCS is thought to work via short-term modulation of membrane potential (81–83) with longer-term effects due to changes in synaptic connectivity (84). In patients with schizophrenia, there have been efforts to use tDCS to modify specific symptoms, such as auditory hallucinations (85).…”

Section: Open Questions and Future Directionsmentioning

confidence: 99%

Diffusion Imaging of White Matter in Schizophrenia: Progress and Future Directions

Karlsgodt

2016

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Diffusion tensor imaging (DTI) is a powerful tool for the in-vivo assessment of white matter microstructure. The application of DTI methodologies to the study of schizophrenia has supported and advanced the hypothesis of schizophrenia as a disorder of disrupted connectivity. In the context of impaired structural connectivity, the extended time frame of white matter development may offer unique opportunities for treatment that can capitalize on the neural flexibility that is still present in the period leading up to and after disease onset. Therefore, it is important to gain a clear understanding of white matter deficits and how they may emerge and change across the illness. However, while there is broad consistency in the findings of white matter deficits in patients with schizophrenia, there is also a great deal of variability in specific findings across studies. In this review, the aim is to move beyond summarizing case-control analyses, to consider the many factors that may impact DTI measures, to explain variability of findings, and to explore future directions for the field. The topics explored include ways to parse DTI patterns associated with different disease subtypes, ways in which novel and established treatments might interact with or enhance white matter, ways of dissociating developmental change from the disease process itself, and understanding the role of emerging analytic methodologies.

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“…Recently, neuromodulation therapy has been clinically recommended for treating cognitive deficits in psychiatric disorders [64][65][66][67][68]. Our results in this study may suggest that prefrontal modulation in OD patients might be treated by using repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) in a dental clinic.…”

Section: Discussionmentioning

confidence: 76%

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

et al. 2018

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Objectives Neuropsychological associations can be considerable in occlusal dysesthesia (OD) patients who routinely complain of persistent occlusal discomfort, and somatization effects in the superior medial prefrontal cortex and the temporal and parietal regions are also present. However, the relationship between physical activity, i.e., chewing, prefrontal cognitive demand, and psychiatric states in OD patients remains unclear. We investigated this relationship in this study. Materials and methods OD patients (n = 15) and healthy control (n = 15; HC) subjects were enrolled in this study. Occlusal contact, chewing activities of the masticatory muscles, prefrontal activities, and psychiatric states such as depression and somatization, of the participants were evaluated. Functional near-infrared spectroscopy was used to determine prefrontal hemodynamics and the Symptom Checklist-90-R was used to score the psychiatric states. Results We observed a significant association between prefrontal deactivation during chewing and somatization subscales in OD patients. Further, there were no significant differences with regard to the occlusal state and chewing physical activities between the OD patients and HC subjects. Conclusions Chewing-related prefrontal deactivation may be associated with somatization severity in OD patients. Clinical relevance fNIRS is a functional imaging method that uses the principal of neuro-vascular couplings. It is applicable for evaluation of psychiatric state based on prefrontal cortex blood flow in patients with psychiatric disorders.

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Transcranial direct current stimulation in psychiatric disorders

Cited by 138 publications

References 134 publications

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Diffusion Imaging of White Matter in Schizophrenia: Progress and Future Directions

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

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