Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

Nitsche, Michael A.; Polanía, Rafael; Kuo, Min‐Fang

doi:10.1002/9781118568323.ch13

Cited by 9 publications

(7 citation statements)

References 129 publications

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“…Alternatively, an electrode configuration has been developed to optimize stimulation focality on the basis of the modelling of electrical field strength. The so-called high definition tDCS (HD-tDCS) is one of these approaches (Nitsche et al, 2015). Relatively small electrodes are placed in the vicinity of the stimulation electrode for this approach (Datta et al, 2009).…”

Section: High Definition Transcranial Direct Current Stimulationmentioning

confidence: 99%

“…Transcranial alternating current stimulation (tACS) is relatively a newly developed stimulation technique that non-invasively modulates cortical excitability and activity. While tDCS induces neuroplasticity via the constant polarization of neuronal membrane potentials with the application of a tonic subthreshold direct current, tACS is thought to affect neuronal membrane potentials by oscillatory electrical stimulation with a specific frequency (Nitsche et al, 2015). The stimulation used for tACS and its duration are quite similar to tDCS.…”

Section: High Definition Transcranial Alternating Current Stimulationmentioning

confidence: 99%

See 1 more Smart Citation

Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond

Takeuchi

Berényi

2020

Neuroscience Research

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Oscillatory brain activities support many physiological functions from motor control to cognition. Disruptions of the normal oscillatory brain activities are commonly observed in neurological and psychiatric disorders including epilepsy, Parkinson's disease, Alzheimer's disease, schizophrenia, anxiety/traumarelated disorders, major depressive disorders, and drug addiction. Therefore, these disorders can be considered as common oscillation defects despite having distinct behavioral manifestations and genetic causes. Recent technical advances of neuronal activity recording and analysis have allowed us to study the pathological oscillations of each disorder as a possible biomarker of symptoms. Furthermore, recent advances in brain stimulation technologies enable time-and space-targeted interventions of the pathological oscillations of both neurological disorders and psychiatric disorders as possible targets for regulating their symptoms.

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Section: High Definition Transcranial Direct Current Stimulationmentioning

confidence: 99%

Section: High Definition Transcranial Alternating Current Stimulationmentioning

confidence: 99%

Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond

Takeuchi

Berényi

2020

Neuroscience Research

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“…Non-invasive brain stimulation techniques may constitute promising approaches to investigate the relationship between brain structure and function and to develop cognitive enhancement strategies (Fertonani and Miniussi, 2016;Kuo and Nitsche, 2012;Nitsche et al, 2015). Importantly, such techniques have been discussed as a potential intervention to counteract age-related cognitive decline and reduced neural efficacy (Mameli et al, 2014;Perceval et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Age-dependent effects of brain stimulation on network centrality

et al. 2018

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Functional magnetic resonance imaging (fMRI) studies have suggested that advanced age may mediate the effects of transcranial direct current stimulation (tDCS) on brain function. However, studies directly comparing neural tDCS effects between young and older adults are scarce and limited to task-related imaging paradigms. Resting-state (rs-) fMRI, that is independent of age-related differences in performance, is well suited to investigate age-associated differential neural tDCS effects. Three "online" tDCS conditions (anodal, cathodal, sham) were compared in a cross-over, within-subject design, in 30 young and 30 older adults. Active stimulation targeted the left sensorimotor network (active electrode over left sensorimotor cortex with right supraorbital reference electrode). A graph-based rs-fMRI data analysis approach (eigenvector centrality mapping) and complementary seed-based analyses characterized neural tDCS effects. An interaction between anodal tDCS and age group was observed. Specifically, centrality in bilateral paracentral and posterior regions (precuneus, superior parietal cortex) was increased in young, but decreased in older adults. Seed-based analyses revealed that these opposing patterns of tDCS-induced centrality modulation originated from differential effects of tDCS on functional coupling of the stimulated left paracentral lobule. Cathodal tDCS did not show significant effects. Our study provides first evidence for differential tDCS effects on neural network organization in young and older adults. Anodal stimulation mainly affected coupling of sensorimotor with ventromedial prefrontal areas in young and decoupling with posteromedial areas in older adults.

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“…The same applies to age-specific neurochemical, functional, and morphological differences (Antonenko et al, 2017 , 2019 ). Moreover, intra- and interindividual differences in neurotransmitter concentration (e.g., in dopamine, GABA, glutamate) as well as concentration and genotype of brain-derived neurotrophic factor or catechol-O-methyl transferase may lead to distinct tDCS-induced modulatory neural and behavioral effects (Teo et al, 2014 ; Li et al, 2015 ; Nitsche et al, 2015 ; Stephens et al, 2017 ; Horne et al, 2020 ). For instance, Horne et al ( 2020 ) reported a transfer effect in visual episodic memory in Val/Val carriers of aforementioned genes after tDCS coupled with decision-making training, whereas no beneficial training or transfer effect was observed in carriers of other genotypes.…”

Section: Discussionmentioning

confidence: 99%

Functional Effects of Bilateral Dorsolateral Prefrontal Cortex Modulation During Sequential Decision-Making: A Functional Near-Infrared Spectroscopy Study With Offline Transcranial Direct Current Stimulation

Schommartz

Dix

Passow

et al. 2021

Front. Hum. Neurosci.

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The ability to learn sequential contingencies of actions for predicting future outcomes is indispensable for flexible behavior in many daily decision-making contexts. It remains open whether such ability may be enhanced by transcranial direct current stimulation (tDCS). The present study combined tDCS with functional near-infrared spectroscopy (fNIRS) to investigate potential tDCS-induced effects on sequential decision-making and the neural mechanisms underlying such modulations. Offline tDCS and sham stimulation were applied over the left and right dorsolateral prefrontal cortex (dlPFC) in young male adults (N = 29, mean age = 23.4 years, SD = 3.2) in a double-blind between-subject design using a three-state Markov decision task. The results showed (i) an enhanced dlPFC hemodynamic response during the acquisition of sequential state transitions that is consistent with the findings from a previous functional magnetic resonance imaging (fMRI) study; (ii) a tDCS-induced increase of the hemodynamic response in the dlPFC, but without accompanying performance-enhancing effects at the behavioral level; and (iii) a greater tDCS-induced upregulation of hemodynamic responses in the delayed reward condition that seems to be associated with faster decision speed. Taken together, these findings provide empirical evidence for fNIRS as a suitable method for investigating hemodynamic correlates of sequential decision-making as well as functional brain correlates underlying tDCS-induced modulation. Future research with larger sample sizes for carrying out subgroup analysis is necessary in order to decipher interindividual differences in tDCS-induced effects on sequential decision-making process at the behavioral and brain levels.

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Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

Cited by 9 publications

References 129 publications

Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond

Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond

Age-dependent effects of brain stimulation on network centrality

Functional Effects of Bilateral Dorsolateral Prefrontal Cortex Modulation During Sequential Decision-Making: A Functional Near-Infrared Spectroscopy Study With Offline Transcranial Direct Current Stimulation

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