Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug-naïve restless legs syndrome: a proof-of-concept clinical trial

Koo, Yong Seo; Kim, Sung Min; Lee, Chany; Lee, Byeong Uk; Moon, Yeji; Cho, Yong Won; Im, Chang-Hwan; Choi, Jeong Woo; Kim, Kyung Hwan; Jung, Ki Young

doi:10.1016/j.sleep.2014.07.032

Cited by 27 publications

(28 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Not only are the specific effects of interest in supporting people with this condition, but the impact of group interaction needs to be partitioned in outcomes analysis in future trials of therapies. None of the eleven randomized controlled trials investigating nonpharmacological therapies for RLS [12][13][14][15][16][17][18][19][20][21][22] have provided insight into the potential effects of group therapy on symptoms, so this seems to be an important target for future attention.…”

Section: Discussionmentioning

confidence: 99%

“…However, high-quality guidelines published by Aurora et al 10 (AGREE assessment "recommended" 11 ) concluded that there was insufficient evidence for nonpharmacological therapy. A recent review by the authors of eleven randomized trials [12][13][14][15][16][17][18][19][20][21][22] concluded that some nonpharmacological interventions including exercise and acupuncture seem beneficial for RLS symptoms; however, few studies were identified and the level of evidence was often not high. Given common unwanted side effects associated with pharmacological management, nonpharmacological treatment options may be valuable for symptom reduction.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

2018

View full text Add to dashboard Cite

show abstract

“…The age of the participants varied from 12.3 to 73.4 years. Only 8 studies out of 40 reported transient adverse effects associated to the tES procedure (41)(42)(43)(44)(45)(46)(47)(48). Overall, the quality assessment was satisfactory (mean: 22.1 ± 3.99).…”

Section: Literature Searchmentioning

confidence: 99%

The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Transcranial Electrical Stimulation (tES) is a promising non-invasive brain modulation tool. Over the past years, there have been several attempts to modulate sleep with tES-based approaches in both the healthy and pathological brains. However, data about the impact on measurable aspects of sleep remain scattered between studies, which prevent us from drawing firm conclusions. We conducted a systematic review of studies that explored the impact of tES on neurophysiological sleep oscillations, sleep patterns measured objectively with polysomnography, and subjective psychometric assessments of sleep in both healthy and clinical samples. We searched four main electronic databases to identify studies until February 2020. Forty studies were selected including 511 healthy participants and 452 patients. tES can modify endogenous brain oscillations during sleep. Results concerning changes in sleep patterns are conflicting, whereas subjective assessments show clear improvements after tES. Possible stimulation-induced mechanisms within specific cortico-subcortical sleep structures and networks are discussed. Although these findings cannot be directly transferred to the clinical practice and sleep-enhancing devices development for healthy populations, they might help to pave the way for future researches in these areas. PROSPERO registration number 178910.

show abstract

“…Nevertheless, such effects have not been observed after cortical stimulation [ 108 ]. Those authors implemented tDCS on bilateral M1 (CZ position, legs representation) with a current intensity of 2 mA during 20 min for 5 sessions/2 weeks.…”

Section: Effect Of Tdcs On the Motor Function In Clinical Populationmentioning

confidence: 99%

Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review

Sánchez-Kuhn

Pérez-Fernández

Cánovas³

et al. 2017

BioMed Eng OnLine

View full text Add to dashboard Cite

The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity. These local changes additionally have shown long-lasting effects, evidenced by its promotion of the brain-derived neurotrophic factor. Due to its easy and safe application and its neuromodulatory effects, tDCS has attracted a big attention in the motor neurorehabilitation field among the last years. Therefore, the present manuscript updates the knowledge available about the main concept of tDCS, its practical use, safety considerations, and its underlying mechanisms of action. Moreover, we will focus on the empirical data obtained by studies regarding the application of tDCS on the motor function of healthy and clinical population, comprising motor deficiencies of a variety of pathologies as Parkinson’s disease, stroke, multiple sclerosis and cerebral palsy, among others. Finally, we will discuss the main current issues and future directions of tDCS as a motor neurorehabilitation tool.Electronic supplementary materialThe online version of this article (doi:10.1186/s12938-017-0361-8) contains supplementary material, which is available to authorized users.

show abstract

Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug-naïve restless legs syndrome: a proof-of-concept clinical trial

Cited by 27 publications

References 52 publications

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review

Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review

Contact Info

Product

Resources

About