Transcranial duplex sonography for monitoring circle of Willis artery occlusion in a rat embolic stroke model

High-density Lipoprotein–based Therapy Reduces the Hemorrhagic Complications Associated With Tissue Plasminogen Activator Treatment in Experimental Stroke

“…31 The percentage of hematoma and death differed significantly between the 2 models probably because of the difference in MCA occlusion time. As we have shown in a duplex sonography study, in a similar embolic stroke model, 29% of rats with confirmed MCAO occlusion had undergone recanalization between 1 and 4 hours after stroke onset, 32 whereas MCA occlusion induced by a filament lasted exactly 4 hours.…”

Impact of intracranial blood-flow redistribution on stroke size during ischemia–reperfusion in 7-day-old rats

“…This could allow generating homogeneous groups of animal for neuroprotective studies, making them more specific, less expensive and time-consuming. US imaging is also a reliable tool to monitor the time-course of arterial recanalization, and is able to predict infarct volume in an adult rat embolic-stroke model (Lapergue et al, 2011).…”

Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia–ischemia

“…A rise in mean blood-flow velocities (mBFVs) both in the contralateral ICA, and the BT was observed during ischemia [permanent MCA occlusion (pMCAo) and transient ipsilateral CCA occlusion]. In contrast, such a rise in mBFVs was not detected during ischemia in a similar stroke model applied in the adult rat (Lapergue et al, 2011), suggesting delayed and/or inadequate or absence of collateral support during ischemia. P7 rat pups subjected to combined pMCAo and transient double common carotid artery (CCA) occlusion a rise in mBFVs in the BT (Fig.…”