Transcranial magnetic stimulation a new therapeutic approach to the treatment of depressive illness

Conca, Andreas; Koppi, St.; Swoboda, E.; Krecké, N.; König, Peter

doi:10.1016/0924-9338(96)88883-3

Cited by 3 publications

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“…The neurophysiological technique of prolonged repetitive rapid-rate transcranial magnetic stimulation (rTMS) has been proposed as a new physical treatment for depression (Belmaker et al, 1995 ;George and Wasserman, 1994 ;Sackeim, 1994 ;Schlaepfer, 1998 ;Zyss, 1994). The present clinical results are favourable (Conca et al, 1996 ;Geller et al, 1997 ;George et al, 1995George et al, , 1997Pascual-Leone et al, 1996Wassermann, 1997). In animal experiments it produced biochemical and behavioural effects regarded as correlating well with clinical activity (Belmaker, 1998 ;Ben-Shachar et al, 1997 ;Fleischman et al, 1994Fleischman et al, , 1995Fujiki and Steward, 1997 ;Zyss et al, 1997b).…”

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confidence: 82%

The influence of rapid-rate transcranial magnetic stimulation (rTMS) parameters on rTMS effects in Porsolt's forced swimming test

Zyss¹,

Mamczarz

Vetulani

1999

Int. J. Neuropsychopharm.

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To assess the similarity of the behavioural effects of the rapid transcranial magnetic stimulation (rTMS) to those produced by other antidepressant treatments, in particular to repeated electroconvulsive shock (ECS), we carried out experiments on Wistar rats. The effects of a standard ECS procedure (9 daily treatments; the current parameters: 150 mA, 50 Hz, 0.5 s) were compared with 18 d treatment with rTMS of the same field intensity of 1.6 T but with different stimulation frequency (20 or 30 Hz) and a different number of sessions (9 or 18). Twenty-four hours after the last treatment the forced swimming test was carried out and the immobility time was recorded. The standard ECT reduced the immobility by 50%, the intensive rTMS (90 or 104 K impulses for the whole period of treatment) caused a significant effect, although smaller than that induced by ECT (reduction by 20-30%). The stimulation at 20 Hz required 18 treatment sessions to produce a significant effect, while only 9 sessions with stimulation at 30 Hz were sufficient to produce a comparable result. This suggests that the effectiveness of rTMS may be augmented by increasing the number or frequency of rTMS impulses.

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