Transcranial magnetic stimulation at 1Hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months

Le, Kai; Liu, Ling; Sun, Man-li; Hu, Ling; Xiao, Nong

doi:10.1016/j.jocn.2012.01.049

Cited by 105 publications

(74 citation statements)

References 29 publications

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“…Several studies have described reductions of tic severity by repetitive TMS over the SMA, [47][48][49] although there is no consensus. 50 Bäumer et al 51 found abnormal functional interhemispheric connectivity in TS accompanied by an altered structure-function relationship in the motor corpus callosum in a combined TMS and diffusion-tensor MRI study with stimuli in hand muscles.…”

Section: Tmsmentioning

confidence: 99%

Functional neuroimaging in Tourette syndrome: recent perspectives

Debes¹,

Préel²,

Skov³

2017

NAN

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Section: Tmsmentioning

confidence: 99%

Functional neuroimaging in Tourette syndrome: recent perspectives

Debes¹,

Préel²,

Skov³

2017

NAN

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“…In TD patients, the SMA has been linked to tic generation and sensory premonitory urges (Bohlhalter et al, 2006;Hampson et al, 2009). Additionally, multiple studies showed that repetitive transcranial magnetic stimulation (rTMS) applied to the SMA was effective to reduce tic symptoms (Kwon et al, 2011;Le et al, 2013;Mantovani et al, 2006Mantovani et al, , 2007. LRPs are also generated partly by the SMA (Rektor, 2002), and since we found a reduction in tics frequency, as well as improvements of rLRP peak amplitude, we propose that our treatment induced a physiological modification in the functioning of the SMA and probably on the top down neural mechanisms involved in the control of tics.…”

Section: Cbt Has Normalizing Effects On the Activation Of The Pre-motmentioning

confidence: 99%

Cognitive-behavioral therapy induces sensorimotor and specific electrocortical changes in chronic tic and Tourette's disorder

et al. 2015

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“…Repetitive transcranial magnetic stimulation (rTMS), inducing an electric current in cortical regions via a pulsed magnetic field, has been shown to be efficient in tic reduction when applied at 1 Hz over the supplementary motor area (SMA; Mantovani et al, 2006). In children, positive results lasted at least 6 months (Le et al, 2013). However these studies were open label without sham control.…”

Section: Introductionmentioning

confidence: 99%

Cathodal tDCS Over Motor Cortex Does Not Improve Tourette Syndrome: Lessons Learned From a Case Series

Behler

Leitner

Mezger

et al. 2018

Front. Behav. Neurosci.

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Introduction: Current pathophysiological hypotheses of Gilles de la Tourette Syndrome (GTS) refer to temporally abnormal neuronal activation in cortico-striato-thalamo-cortical (CSTC) networks. Modifying cortical activity by non-invasive brain-stimulation appears to be a new treatment option in GTS.Background: Previous studies suggested therapeutic effects of cathodal transcranial direct current stimulation (tDCS) to pre-supplementary motor areas (SMA), however, treatment modalities concerning electrode placement, current intensity and stimulation-rate have not been systematically explored. Aim of this study was to assess efficacy of an alternative stimulation regime on GTS symptoms in a pilot study. To test a treatment protocol with tDCS twice a day, we administered 10 sessions over 5 days of bilateral cathodal tDCS (30 min, 2 mA) over the pre-SMA in three patients with severe GTS. Tic severity as well as obsessive-compulsive (OC) symptoms and affective scales were rated before and after tDCS treatment.Discussion: Only one out of three patients showed a 34.5% reduction in tic severity. The two other patients showed an increase in tic severity. All patients showed a mild increase in positive affect and a reduction in negative affect, OC symptom changes were heterogeneous. Our results do not support earlier findings of extensive therapeutic effects of cathodal tDCS on tics in patients with GTS and show that prediction of stimulation effects on a targeted brain area remains inaccurate.Concluding Remarks: Future research will have to focus on the determination of most effective stimulation modes regarding site, polarity and frequency of tDCS in GTS patients.

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Transcranial magnetic stimulation at 1Hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months

Cited by 105 publications

References 29 publications

Functional neuroimaging in Tourette syndrome: recent perspectives

Functional neuroimaging in Tourette syndrome: recent perspectives

Cognitive-behavioral therapy induces sensorimotor and specific electrocortical changes in chronic tic and Tourette's disorder

Cathodal tDCS Over Motor Cortex Does Not Improve Tourette Syndrome: Lessons Learned From a Case Series

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