Transcranial magnetic stimulation demonstrates a role for the ventrolateral prefrontal cortex in emotion perception

Chick, Christina F.; Rolle, Cammie; Trivedi, Hersh; Monuszko, Karen; Etkin, Amit

doi:10.1016/j.psychres.2019.112515

Cited by 17 publications

(5 citation statements)

References 82 publications

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“…Previous studies have shown that the VLPFC is involved in downregulating emotion responses by its structural and functional connectivity to the amygdala (Wager 2008). As shown by (Chick et al 2019) when TMS is used on VLPFC, processing of emotional facial expressions is interrupted. Consistent with this explanation we find that beta values are higher in VLPFC for explicit recognition conditions.…”

Section: The Role Of Vlpfcmentioning

confidence: 99%

The representation of bodies in high level visual, prefrontal and inferior parietal cortex varies with explicit vs. implicit expression perception

Marrazzo

Vaessen

Gelder

2020

Preprint

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Recent studies provided an increasingly detailed understanding of how visual objects like faces or bodies are categorized. What is less clear is whether a category attribute like the emotional expression influences category representation as is limited to extra-category selective areas and whether the coding of the expression in category and extra category areas is influenced by the task. Using functional magnetic resonance imaging (fMRI) and multivariate methods, we measured BOLD responses while participants viewed whole body expressions and performed an explicit (emotion) and implicit (shape) recognition task. Our results show that the type of task can be decoded in EBA, VLPFC and IPL with higher activity for the explicit task condition in the first two areas and no evidence of emotion specificity processes in any of them. During explicit recognition of the body expression, category representation was strengthened while action related information was be suppressed. These results provide evidence that body representations in high level visual cortex and frontoparietal cortex are task sensitive and that body selective areas differentially contribute to expression representation based on their different anatomical connectivity.

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Section: The Role Of Vlpfcmentioning

confidence: 99%

The representation of bodies in high level visual, prefrontal and inferior parietal cortex varies with explicit vs. implicit expression perception

Marrazzo

Vaessen

Gelder

2020

Preprint

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“…In addition, we note that the most impactful electric field effects on antidepressant outcome were not found in the targeted DLPFC, but in Brodmann area 47 (BA 47), a region categorized as ventrolateral prefrontal cortex (VLPFC), inferior frontal gyrus (IFG), and pars orbitalis. BA 47 has been implicated in language processing ( 54 ), emotion perception and regulation ( 55 ), social cognition ( 56 ), and resilience ( 57 ), and functions as a key node in a ventral emotion regulation network ( 58 ). Reduced gray matter volume and altered connectivity of the VLPFC have been implicated in suicidality in late-life depression ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

Electric field distribution predicts efficacy of accelerated intermittent theta burst stimulation for late-life depression

Quinn,

Upston,

Jones

et al. 2023

Front. Psychiatry

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IntroductionRepetitive transcranial magnetic stimulation (rTMS) is a promising intervention for late-life depression (LLD) but may have lower rates of response and remission owing to age-related brain changes. In particular, rTMS induced electric field strength may be attenuated by cortical atrophy in the prefrontal cortex. To identify clinical characteristics and treatment parameters associated with response, we undertook a pilot study of accelerated fMRI-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex in 25 adults aged 50 or greater diagnosed with LLD and qualifying to receive clinical rTMS.MethodsParticipants underwent baseline behavioral assessment, cognitive testing, and structural and functional MRI to generate individualized targets and perform electric field modeling. Forty-five sessions of iTBS were delivered over 9 days (1800 pulses per session, 50-min inter-session interval). Assessments and testing were repeated after 15 sessions (Visit 2) and 45 sessions (Visit 3). Primary outcome measure was the change in depressive symptoms on the Inventory of Depressive Symptomatology-30-Clinician (IDS-C-30) from Visit 1 to Visit 3.ResultsOverall there was a significant improvement in IDS score with the treatment (Visit 1: 38.6; Visit 2: 31.0; Visit 3: 21.3; mean improvement 45.5%) with 13/25 (52%) achieving response and 5/25 (20%) achieving remission (IDS-C-30 < 12). Electric field strength and antidepressant effect were positively correlated in a subregion of the ventrolateral prefrontal cortex (VLPFC) (Brodmann area 47) and negatively correlated in the posterior dorsolateral prefrontal cortex (DLPFC).ConclusionResponse and remission rates were lower than in recently published trials of accelerated fMRI-guided iTBS to the left DLPFC. These results suggest that sufficient electric field strength in VLPFC may be a contributor to effective rTMS, and that modeling to optimize electric field strength in this area may improve response and remission rates. Further studies are needed to clarify the relationship of induced electric field strength with antidepressant effects of rTMS for LLD.

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“…In line with this hypothesis, neuroimaging studies in individuals with PTSD point clearly to a decreased capacity for emotion regulation, where emotional stress may alter cognitive networks that process information about perception, salience processing and creating goal-oriented responses. This research points to aberrations at the prefrontal cortex that may play a role in disrupting emotion processing among individuals with PTSD, which may shape intense reactions to traumatic reminders (e.g., a triggering sound, sight or smell) and lead to decreased cognitive control of behavioral responses to emotionally salient stimuli (Frewen et al, 2008;Brown and Morey, 2012;Hayes et al, 2012;Helpman et al, 2016;Rolle et al, 2019).…”

Section: Cortical Responses -Awareness and Context Of Sensory Experiencementioning

confidence: 98%

How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD

2021

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Post-traumatic stress disorder (PTSD) is triggered by an individual experiencing or witnessing a traumatic event, often precipitating persistent flashbacks and severe anxiety that are associated with a fearful and hypervigilant presentation. Approximately 14–30% of traumatized individuals present with the dissociative subtype of PTSD, which is often associated with repeated or childhood trauma. This presentation includes symptoms of depersonalization and derealization, where individuals may feel as if the world or self is “dream-like” and not real and/or describe “out-of-body” experiences. Here, we review putative neural alterations that may underlie how sensations are experienced among traumatized individuals with PTSD and its dissociative subtype, including those from the outside world (e.g., touch, auditory, and visual sensations) and the internal world of the body (e.g., visceral sensations, physical sensations associated with feeling states). We postulate that alterations in the neural pathways important for the processing of sensations originating in the outer and inner worlds may have cascading effects on the performance of higher-order cognitive functions, including emotion regulation, social cognition, and goal-oriented action, thereby shaping the perception of and engagement with the world. Finally, we introduce a theoretical neurobiological framework to account for altered sensory processing among traumatized individuals with and without the dissociative subtype of PTSD.

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Transcranial magnetic stimulation demonstrates a role for the ventrolateral prefrontal cortex in emotion perception

Cited by 17 publications

References 82 publications

The representation of bodies in high level visual, prefrontal and inferior parietal cortex varies with explicit vs. implicit expression perception

The representation of bodies in high level visual, prefrontal and inferior parietal cortex varies with explicit vs. implicit expression perception

Electric field distribution predicts efficacy of accelerated intermittent theta burst stimulation for late-life depression

How Processing of Sensory Information From the Internal and External Worlds Shape the Perception and Engagement With the World in the Aftermath of Trauma: Implications for PTSD

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