Transcranial Magnetic Stimulation in Mania: A Controlled Study

Grisaru, Nimrod; Chudakov, Bella; Yaroslavsky, Yuri; Belmaker, Robert H.

doi:10.1176/ajp.155.11.1608

Cited by 179 publications

(70 citation statements)

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“…Also, functional magnetic resonance activation during an n-back task where subjects had to identify letters two positions back in a letter sequence, replicated prior findings of bilateral dorsolateral prefrontal cortex and parietal regions in healthy controls, whereas BD patients revealed reduced right parietal activation (Townsend et al, 2010). Moreover, a study (Grisaru et al, 1998) investigated the clinical properties of repetitive transcranial magnetic stimulation applied over the left and right prefrontal cortex. The results showed that manic symptoms of BD patients significantly improved after repetitive transcranial magnetic stimulation over the right prefrontal cortex compared to BD patients receiving repetitive transcranial magnetic stimulation of the left prefrontal cortex.…”

Section: Introductionsupporting

confidence: 72%

“…However, a right hemisphere involvement in BD has been suggested by findings of decreased gray matter volume in right prefrontal and parietal lobes (Lyoo et al, 2004;Adler et al, 2005) as well as cortical thinning in right superior parietal areas (Lyoo et al, 2006). In addition, neuroimaging and neurophysiological studies revealed atypical functional brain organization, particularly involving the right hemisphere rather than the left (e.g., Grisaru et al, 1998;Rubinsztein et al, 2001;Townsend et al, 2010). For example, a positron emission tomography study using a decision-making task, where participants were asked to choose between a red and a blue box to find a token, showed a decreased right superior frontal activation in manic BD patients compared to healthy controls (Rubinsztein et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Right fronto-parietal dysfunction underlying spatial attention in bipolar disorder

Najt

Bayer

Hausmann

2013

Psychiatry Research

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Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Psychiatry Research, 210, 2, 15 December 2013, 10.1016/j.psychres.2013.07.021. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. In contrast to healthy controls, BD patients did not significantly deviate from the veridical center, regardless which hand was used to bisect horizontal lines. This finding indicates an atypical functional cerebral asymmetry in visuospatial attention in BD euthymia, supporting the idea of a dysfunction especially in the right fronto-parietal cortex.

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Section: Introductionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Right fronto-parietal dysfunction underlying spatial attention in bipolar disorder

Najt

Bayer

Hausmann

2013

Psychiatry Research

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“…A reversed pattern of lateralization in a subset of patients could explain why some patients paradoxically do better with an inhibitory stimulus to the left prefrontal cortex and worse with an excitatory one (52,54). The success of Grisaru's group in treating mania with high-frequency rTMS to the right prefrontal cortex complements this model (60).…”

Section: Pulse Frequency-slow Versus Fast Rtmsmentioning

confidence: 95%

Transcranial Magnetic Stimulation in the Treatment of Depression

Gershon

Dannon²,

Grunhaus³

2003

AJP

459

246

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Objective: Transcranial magnetic stimulation (TMS) is a noninvasive and easily tolerated method of altering cortical physiology. The authors evaluate evidence from the last decade supporting a possible role for TMS in the treatment of depression and explore clinical and technical considerations that might bear on treatment success. Method:The authors review English-language controlled studies of nonconvulsive TMS therapy for depression that appeared in the MEDLINE database through early 2002, as well as one study that was in press in 2002 and was published in 2003. In addition, the authors discuss studies that have examined technical, methodological, and clinical treatment parameters of TMS. Results:Most data support an antidepressant effect of high-frequency repetitive TMS administered to the left prefrontal cortex. The absence of psychosis, younger age, and certain brain physiologic markers might predict treatment success. Technical parameters possibly affecting treatment success include intensity and duration of treatment, but these suggestions require systematic testing.Conclusions: TMS shows promise as a novel antidepressant treatment. Systematic and large-scale studies are needed to identify patient populations most likely to benefit and treatment parameters most likely to produce success. In addition to its potential clinical role, TMS promises to provide insights into the pathophysiology of depression through research designs in which the ability of TMS to alter brain activity is coupled with functional neuroimaging. (Am J Psychiatry 2003; 160:835-845)In 1831, Michael Faraday discovered that electrical currents can be converted into magnetic fields and vice versa. His principle of mutual induction is the basis of transcranial magnetic stimulation (TMS). In TMS, a bank of capacitors is rapidly discharged into an electric coil to produce a magnetic field pulse (Figure 1). When the coil is placed near the head of a human or animal, the magnetic field penetrates the brain and induces an electric field in the underlying region of the cerebral cortex (4) (Figure 2). An electrical field of sufficient intensity will depolarize cortical neurons, generating action potentials. These then propagate to exert their biological effects. For example, TMS over the left motor cortex causes action potentials that propagate through the corticospinal tract, causing twitches in contralateral skeletal muscles.This new technology has been used to affect underlying brain tissue at several levels. First, TMS can alter regional activity within the cortex. Positron emission tomography (PET) has revealed changes in cortical metabolism and dose-dependent changes in regional cortical blood flow in response to TMS (5-7). Such changes are also observed at sites distant from the magnetic stimulus, showing that the effects of TMS propagate to other parts of the brain (6, 7). The connections demonstrated in this manner correspond to known neural pathways in nonhuman primates, suggesting that the propagation of TMS effects occurs by means of...

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“…In the last two decades, research on using these tools to treat conditions such as depression 6 , mania 7 , obsessive-compulsive disorder 8 and post-traumatic stress disorder 9 began to appear. The use of electric currents for treating psychiatric disorders began in the 18 th century with the development of the voltaic pile.…”

mentioning

confidence: 99%

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

Iannone

Cruz

Brasil‐Neto

et al. 2016

Arq. Neuro-Psiquiatr.

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Transcranial magnetic stimulation (TMS) has recently been investigated as a possible adjuvant treatment for many neuropsychiatric disorders, and has already been approved for the treatment of drug-resistant depression in the United States and in Brazil, among other countries. Although its use in other neuropsychiatric disorders is still largely experimental, many physicians have been using it as an off-label add-on therapy for various disorders. More recently, another technique, transcranial direct current stimulation (tDCS), has also become available as a much cheaper and portable alternative to TMS, although its mechanisms of action are different from those of TMS. The use of off-label therapeutic TMS or tDCS tends to occur in the setting of diseases that are notoriously resistant to other treatment modalities. Here we discuss the case of anxiety disorders, namely panic and post-traumatic stress disorders, highlighting the uncertainties and potential problems and benefits of the clinical use of these neuromodulatory techniques at the current stage of knowledge.

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Transcranial Magnetic Stimulation in Mania: A Controlled Study

Abstract: The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.

Cited by 179 publications

References 9 publications

Right fronto-parietal dysfunction underlying spatial attention in bipolar disorder

Right fronto-parietal dysfunction underlying spatial attention in bipolar disorder

Transcranial Magnetic Stimulation in the Treatment of Depression

Transcranial magnetic stimulation and transcranial direct current stimulation appear to be safe neuromodulatory techniques useful in the treatment of anxiety disorders and other neuropsychiatric disorders

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