Transcranial Magnetic Stimulation of the Cerebellum

Minks, Eduard; Kopickova, Marie; Mareček, Radek; Streitová, Hana; Bareš, Martin

doi:10.5507/bp.2010.020

Cited by 25 publications

(23 citation statements)

References 42 publications

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“…This observation is important and might be critical for developing spatially targeted treatments for migraine. For example, high-frequency rTMS increase and low-frequency rTMS decrease neural excitability of the stimulated cortex [40], [56], [76]. If neuromagnetic high-gamma oscillations could reliably reveal the location and types of cortical dysfunction occurring during the phases of migraine attacks, all of the preventions and treatments targeted at cortical excitability [39], [72], [73] could be refined and optimized.…”

Section: Discussionmentioning

confidence: 99%

Neuromagnetic Abnormality of Motor Cortical Activation and Phases of Headache Attacks in Childhood Migraine

et al. 2013

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The cerebral cortex serves a primary role in the pathogenesis of migraine. This aberrant brain activation in migraine can be noninvasively detected with magnetoencephalography (MEG). The objective of this study was to investigate the differences in motor cortical activation between attacks (ictal) and pain free intervals (interictal) in children and adolescents with migraine using both low- and high-frequency neuromagnetic signals. Thirty subjects with an acute migraine and 30 subjects with a history of migraine, while pain free, were compared to age- and gender-matched controls using MEG. Motor cortical activation was elicited by a standardized, validated finger-tapping task. Low-frequency brain activation (1∼50 Hz) was analyzed with waveform measurements and high-frequency oscillations (65–150 Hz) were analyzed with wavelet-based beamforming. MEG waveforms showed that the ictal latency of low-frequency brain activation was significantly delayed as compared with controls, while the interictal latency of brain activation was similar to that of controls. The ictal amplitude of low-frequency brain activation was significantly increased as compared with controls, while the interictal amplitude of brain activation was similar to that of controls. The ictal source power of high-frequency oscillations was significantly stronger than that of the controls, while the interictal source power of high-frequency oscillations was significantly weaker than that of controls. The results suggest that aberrant low-frequency brain activation in migraine during a headache attack returned to normal interictally. However, high-frequency oscillations changed from ictal hyper-activation to interictal hypo-activation. Noninvasive assessment of cortical abnormality in migraine with MEG opens a new window for developing novel therapeutic strategies for childhood migraine by maintaining a balanced cortical excitability.

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Section: Discussionmentioning

confidence: 99%

Neuromagnetic Abnormality of Motor Cortical Activation and Phases of Headache Attacks in Childhood Migraine

et al. 2013

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“…Magnetic resonance images have been inserted with consent of St. Anne's University Hospital Department of Imaging Methods. For a better idea of the stimulation, see pictures in the articles previously published by our group [3,25].…”

Section: Methodsmentioning

confidence: 99%

“…Transcranial magnetic stimulation (TMS) is a non-invasive electrophysiological method. Cerebellar TMS can be used for studying motor cerebellar connections and functions [2,3]. TMS studies in healthy volunteers and patients with different movement disorders were aimed at assessing changes in motor-evoked potentials (MEP), intracortical inhibition (ICI) [4][5][6][7][8] and intracortical facilitation (ICF) [9,10] in the motor cortex after conditioning stimulus.…”

Section: Introductionmentioning

confidence: 99%

Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks

et al. 2011

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The aim of this study was to find whether 1-Hz cerebellar repetitive transcranial magnetic stimulation (rTMS) could affect upper limb movement in early-stage Parkinson's disease (PD). Twenty patients with PD underwent one session with real and one with sham rTMS. rTMS (1 Hz, 600 pulses) was targeted at the right lateral cerebellum. Before and after rTMS, patients performed two motor tests with their fingers and hands (ball test, nine-hole peg test). The duration of these tests was measured. There were statistically significant differences (p < 0.05) in the results of the tests after real stimulation and sham stimulation. We excluded the impact of learning. After real rTMS, we observed a significantly faster response in the ball test and a slower response in the nine-hole peg test, both on the right upper limb. This study indicates the influence of 1-Hz cerebellar rTMS in modifying the voluntary movements of the upper limb in PD. This influence is differentiated: the improvement of gross motor skills and the worsening of fine motor skills.

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“…RANSCRANIAL MAGNETIC STIMULATION(TMS) is a noninvasive neuromodulation technique which is capable of activating neurons in the brain. In TMS, a time-varying magnetic field generated by stimulator induces an electric field and causes depolarization of neurons in the targeted area via a stimulation coil [1]. When stimulation is applied repetitively over the course of weeks, the effects can create lasting changes to brain activity.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Role of Coil Designs and Anatomical Variations in Cerebellar TMS

et al. 2019

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Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique that is used for treating various neurological disorders such as major depressive disorder. TMS has been gaining popularity in the field of neurostimulation of the cerebellum, since the cerebellum is a complex structure connected with almost the entire central nervous system and TMS has promise for non-invasively probing cerebellar function. Recent studies have discovered that the cerebellum plays an important role not only in motor planning and behavior but also in the cognitive domain. However, few studies have explored how different coil designs and anatomical variations affect the effectiveness of cerebellar TMS. Therefore, in this paper, we investigated the effects of cerebellar TMS with different coil designs positioning on several locations. Finite-element modeling was conducted with Figure-8 coil and D-B80 coil. Each coil was positioned in the center, 1 and 3 cm to the left of center of the cerebellum, and all the locations were tangential to the scalp at a distance of 5 mm. Furthermore, 50 MRI derived head models were used in the computer modeling to examine how anatomical variations affect the distribution and intensity of electric field in cerebellar TMS.

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Transcranial Magnetic Stimulation of the Cerebellum

Cited by 25 publications

References 42 publications

Neuromagnetic Abnormality of Motor Cortical Activation and Phases of Headache Attacks in Childhood Migraine

Neuromagnetic Abnormality of Motor Cortical Activation and Phases of Headache Attacks in Childhood Migraine

Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks

Investigating the Role of Coil Designs and Anatomical Variations in Cerebellar TMS

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