Transcranial magnetic stimulation (TMS) for geriatric depression

Cappon, Davide; Boer, Tim den; Jordan, Caleb; Yu, Wanting; Metzger, Eran D.; Pascual‐Leone, Álvaro

doi:10.1016/j.arr.2021.101531

Cited by 47 publications

(40 citation statements)

References 129 publications

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“…In addition, patients with cancer pain are often complicated with depression, which aggravates the complexity and difficulty of cancer pain treatment, and that is also one of the main reasons for poor analgesic effect ( 16 ). Many studies have found that high frequency rTMS stimulation of the dorsolateral prefrontal cortex (DLPFC) is an effective method for the treatment of depression ( 17 ). At the same time, high-frequency stimulation also relieves neuropathic pain and chronic pain to a certain extent ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Advanced Non-Small-Cell Lung Cancer: A Randomized, Sham-Controlled, Pilot Study

et al. 2022

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ObjectiveCurrent pharmacological intervention for the cancer-related pain is still limited. The aim of this study was to explore whether repetitive transcranial magnetic stimulation (rTMS) could be an effective adjuvant therapy to reduce pain in patients with advanced non-small cell lung cancer (NSCLC).MethodsThis was a randomized, sham–controlled study. A total of 41 advanced NSCLC patients with uncontrolled pain (score≥4 on pain intensity assessed with an 11-point numeric rating scale) were randomized to receive active (10 Hz, 2000 stimuli) (n = 20) or sham rTMS (n = 20) for 3 weeks. Pain was the primary outcome and was assessed with the Numeric Rating Scale (NRS). Secondary outcomes were oral morphine equivalent (OME) daily dose, quality of life (WHO Quality of Life-BREF), and psychological distress (the Hospital Depression and Anxiety Scale). All outcomes were measured at baseline, 3 days, 1 week, 2 weeks, and 3 weeks.ResultsThe pain intensity in both groups decreased gradually from day 3 and decreased to the lowest at the week 3, with a decrease rate of 41.09% in the rTMS group and 23.23% in the sham group. The NRS score of the rTMS group was significantly lower than that of the sham group on the week 2 (p < 0.001, Cohen’s d =1.135) and week 3 (p=0.017, Cohen’s d = -0.822). The OME daily dose, physiology and psychology domains of WHOQOL-BREF scores, as well as the HAM-A and HAM-D scores all were significantly improved at week 3 in rTMS group.ConclusionAdvanced NSCL patients with cancer pain treated with rTMS showed better greater pain relief, lower dosage of opioid, and better mood states and quality of life. rTMS is expected to be a new effective adjuvant therapy for cancer pain in advanced NSCLC patients.

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Section: Introductionmentioning

confidence: 99%

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Advanced Non-Small-Cell Lung Cancer: A Randomized, Sham-Controlled, Pilot Study

et al. 2022

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“…Such results suggested that multisensory stimulation wake-up nursing combined with TMS was more beneficial to the recovery of brain function in patients with massive cerebral infarction and disturbance of consciousness. It has also been suggested that repeated TMS can stimulate neuronal activity in the cerebral cortex, thereby promoting the recovery of brain function and awakening the consciousness of patients [28,29]. e multisensory stimulation wake-up nursing also helps the recovery of the human central nervous system and enhances the activity of neurons in the upper cerebral cortex, thereby enhancing the connection between the cortex and the subcortical tissue and promoting the awakening of patients [30,31].…”

Section: Discussionmentioning

confidence: 99%

Awakening Effect of Transcranial Magnetic Stimulation with Multimodal Magnetic Resonance Imaging under Three-Dimensional Reconstruction Algorithm Combined with Wake-Up Nursing on Patients with Massive Cerebral Infarction

Chen

2022

Concepts in Magnetic Resonance Part A

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This study was aimed to provide arousal treatment for disturbance of consciousness in patients with massive cerebral infarction, using multimodal magnetic resonance imaging (MRI)-assisted transcranial magnetic stimulation (TMS) under three-dimensional reconstruction algorithm combined with wake-up nursing. The application effect was also evaluated. 80 patients with massive cerebral infarction were selected as the research objects. These patients were divided into the control group (routine nursing and TMS) and the experimental group (routine nursing, multisensory stimulation wake-up nursing, and TMS) according to the even- and odd-numbered admission orders. There were 40 cases in each group, and the treatment effects of the two groups were compared and analyzed. The peak signal-to-noise ratio (PSNR) (800 dB) of the bilateral filtering algorithm was higher than that of the wavelet threshold denoising (321 dB) and the nonlocal mean filtering algorithm (455 dB). The segmentation accuracy of the improved region growing method/fuzzy spatial clustering algorithm (96.21% and 97.22%) was higher than that of the unimproved ones (82.11% and 79.99%). The Glasgow Coma Scale (GCS), Coma Recovery Scale-Revised (CRS-R), and Dysfunction Scale (DFS) scores of the experimental group were significantly higher than those of the control group 1 week and 2 weeks after treatment ( P < 0.05 ). The awakening rate of patients in the experimental group (95%) was also significantly higher than that in the control group (72.5%), and the time needed for waking up was (2.28 ± 2.92) hours, lower than that in the control group (4.34 ± 3.49) hours ( P < 0.05 ). The three-dimensional reconstruction algorithm could effectively improve the display effect of MRI images and assist in the examination of diseases. Multisensory stimulation wake-up nursing combined with TMS could promote patients to wake up more quickly and help the recovery of brain function of patients in the treatment of massive cerebral infarction and disturbance of consciousness.

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“…In addition, another interesting study ( 38 ) suggest that rural residence may have a protective effect on veterans' mental health, indicating that the environment is also an important aspect of psychological influence, but the effect on T2DM is not yet known. In recent years, neuromodulation methods such as transcranial magnetic stimulation (TMS) ( 39 , 40 ) and transcranial direct current stimulation (tDCS) ( 41 ) have also been proved to be effective treatments for depression. In the treatment of diabetes, deep repetitive TMS can promote weight loss in obesity and thus prevent T2DM ( 42 ), and tDCS treatment can improve the quality of life and physical function of patients with diabetic polyneuropathy ( 43 ).…”

Section: Treatmentmentioning

confidence: 99%

Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Zhu

Luo

et al. 2022

Front. Cardiovasc. Med.

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Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression.

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Transcranial magnetic stimulation (TMS) for geriatric depression

Cited by 47 publications

References 129 publications

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Advanced Non-Small-Cell Lung Cancer: A Randomized, Sham-Controlled, Pilot Study

Analgesic Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Advanced Non-Small-Cell Lung Cancer: A Randomized, Sham-Controlled, Pilot Study

Awakening Effect of Transcranial Magnetic Stimulation with Multimodal Magnetic Resonance Imaging under Three-Dimensional Reconstruction Algorithm Combined with Wake-Up Nursing on Patients with Massive Cerebral Infarction

Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

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