Transcranial magnetic stimulation (TMS) of the sensorimotor cortex and medial frontal cortex modifies human pain perception

Kanda, Masutaro; Mima, Tatsuya; Oga, Tatsuhide; Matsuhashi, Masao; Toma, Kazunori; Hara, Hidemi; Satow, Takeshi; Nakagawa, Takashi; Rothwell, John C.; Shibasaki, Hiroshi

doi:10.1016/s1388-2457(03)00034-8

Cited by 87 publications

(75 citation statements)

References 47 publications

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“…The stimulation location corresponding to SII was localised 2.5 cm anterior and 6.5 cm superior to the preauricular point, in accord with previous TMS studies [Harris et al, 2002;Kanda et al, 2003]. Finally, the stimulation location corresponding to VI was 2 cm dorsal and 0.6 cm lateral to the calcarine sulcus, which corresponds to the primary visual cortex Fernandez et al, 2002].…”

Section: Figuresupporting

confidence: 84%

Seeing touch in the somatosensory cortex: A TMS study of the visual perception of touch

Bolognini¹,

Rossetti²,

Maravita³

et al. 2011

Human Brain Mapping

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Recent studies suggest the existence of a visuo-tactile mirror system, comprising the primary (SI) and secondary (SII) somatosensory cortices, which matches observed touch with felt touch. Here, repetitive transcranial magnetic stimulation (rTMS) was used to determine whether SI or SII play a functional role in the visual processing of tactile events. Healthy participants performed a visual discrimination task with tactile stimuli (a finger touching a hand) and a control task (a finger moving without touching). During both tasks, rTMS was applied over either SI or SII, and to the occipital cortex. rTMS over SI selectively reduced subject performance for interpreting whether a contralateral visual tactile stimulus contains a tactile event, whereas SII stimulation impaired visual processing regardless of the tactile component. These findings provide evidence for a multimodal sensory-motor system with mirror properties, where somatic and visual properties of action converge. SI, a cortical area traditionally viewed as modality-specific, is selectively implicated in the visual processing of touch. These results are in line with the existence of a sensory mirror system mediating the embodied simulation concept. Hum Brain Mapp 32:2104-2114,

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Section: Figuresupporting

confidence: 84%

Seeing touch in the somatosensory cortex: A TMS study of the visual perception of touch

Bolognini¹,

Rossetti²,

Maravita³

et al. 2011

Human Brain Mapping

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“…However, in a very recent TMS study, double-pulse stimulation over the frontal cortex has been 0022-510X/$ -see front matter D 2004 Elsevier B.V. All rights reserved. doi:10.1016/j.jns.2004.08.008 demonstrated to transitorily suppress the central processing of pain perception, increasing threshold to pain stimuli [12].…”

Section: Introductionmentioning

confidence: 99%

rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study

Brighina

Piazza

Vitello

et al. 2004

Journal of the Neurological Sciences

241

180

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“…The TMS head coil (manufactured by Neotonus, Inc., Marietta, GA, USA) was placed at the midline anteriorly on the patient's scalp. This placement was intended to maximize stimulation of the medial prefrontal area that overlays the anterior cingulate region, which has been implicated in depression and central pain syndromes [11,12].…”

Section: Resultsmentioning

confidence: 99%

“…HBOT is believed to have anti-inflammatory effects, reducing the excess of proinflammatory cytokine activation such as TNF-alpha and facilitating improvement by provocation of stem cell activity [7][8][9][10]. The combination therapy of infused ketamine administered concurrent to TMS appears to address the abnormalities in brain circuits found both in treatment resistant depression and treatment resistant central pain [11][12][13][14][15][16]. Additionally, ketamine is known to act as a TNF-alpha inhibitor, thus favoring an anti-inflammatory effect [17].…”

Section: Introductionmentioning

confidence: 99%

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

Best¹,

Pavel²

2016

J Neurol Neurosci

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Background: This is the first case report of a stepped novel anti-inflammatory treatment plan for a complicated, markedly disabling neuropsychiatric condition with multiple comorbidities. The treatment consisted of 1) hyperbaric oxygen therapy, 2) combination therapy of infused ketamine applied concurrent with transcranial magnetic stimulation, 3) administration of perispinal etanercept, and finally 4) non-invasive transnasal Sphenopalatine Ganglion block.

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Transcranial magnetic stimulation (TMS) of the sensorimotor cortex and medial frontal cortex modifies human pain perception

Cited by 87 publications

References 47 publications

Seeing touch in the somatosensory cortex: A TMS study of the visual perception of touch

Seeing touch in the somatosensory cortex: A TMS study of the visual perception of touch

rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

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