Transcranial parenchymal sonography in patients with Chronic Disorders of Consciousness: Association with neuroimaging data, and beyond

Chillura, Antonino; Naro, Antonino; Cacciola, Alberto; Bramanti, Alessia; Bramantı, Placido; Calabrò, Rocco Salvatore

doi:10.1016/j.concog.2017.04.013

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complex patterns of neuronal activity associated with consciousness are severely damaged in patients with chronic disorders of consciousness (DoC) [11,12,13,14,15,16,17,18]. This has been put in relation to the brain damage-dependent connectivity breakdown between and within fronto-parietal regions influenced by specific circuit modulations of the thalamus [19].…”

Section: Introductionmentioning

confidence: 99%

Functional Brain Network Topology Discriminates between Patients with Minimally Conscious State and Unresponsive Wakefulness Syndrome

Cacciola

Naro

Milardi

et al. 2019

JCM

Self Cite

View full text Add to dashboard Cite

Consciousness arises from the functional interaction of multiple brain structures and their ability to integrate different complex patterns of internal communication. Although several studies demonstrated that the fronto-parietal and functional default mode networks play a key role in conscious processes, it is still not clear which topological network measures (that quantifies different features of whole-brain functional network organization) are altered in patients with disorders of consciousness. Herein, we investigate the functional connectivity of unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) patients from a topological network perspective, by using resting-state EEG recording. Network-based statistical analysis reveals a subnetwork of decreased functional connectivity in UWS compared to in the MCS patients, mainly involving the interhemispheric fronto-parietal connectivity patterns. Network topological analysis reveals increased values of local-community-paradigm correlation, as well as higher clustering coefficient and local efficiency in UWS patients compared to in MCS patients. At the nodal level, the UWS patients showed altered functional topology in several limbic and temporo-parieto-occipital regions. Taken together, our results highlight (i) the involvement of the interhemispheric fronto-parietal functional connectivity in the pathophysiology of consciousness disorders and (ii) an aberrant connectome organization both at the network topology level and at the nodal level in UWS patients compared to in the MCS patients.

show abstract