Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain

Semyachkina-Glushkovskaya, Oxana; Klimova, Maria; Iskra, Tatyana; Bragin, Denis E; Abdurashitov, Arkady S.; Dubrovsky, Alexander; Khorovodov, Alexander; Terskov, Andrey; Blokhina, Inna; Lezhnev, N. N.; Vinnik, Valeria; Agranovich, Ilana; Mamedova, Aysel; Shirokov, Alexander; Navolokin, Nikita A.; Khlebsov, B; Tuchin, Valery V.; Kurths, Jürgen

doi:10.1007/978-3-030-48238-1_9

Cited by 20 publications

(22 citation statements)

References 10 publications

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“…Figure 2 e shows that the spread of FAβ was higher on the ventral than on the dorsal aspect of the brain 3 h after its injection. These data reflect the FAβ distribution from the ventricle to the basal MLVs, playing an important role in the brain drainage and clearance [ 16 , 17 , 30 , 31 , 32 , 33 ]. The dcLNs are the first anatomical station of the CSF exit with dissolved unneeded substances for the brain [ 16 , 17 , 30 , 31 , 32 , 33 ].…”

Section: Resultsmentioning

confidence: 64%

“…These data reflect the FAβ distribution from the ventricle to the basal MLVs, playing an important role in the brain drainage and clearance [ 16 , 17 , 30 , 31 , 32 , 33 ]. The dcLNs are the first anatomical station of the CSF exit with dissolved unneeded substances for the brain [ 16 , 17 , 30 , 31 , 32 , 33 ]. Therefore, the more intensively the substance is released from the brain, the stronger is its level in dcLNs.…”

Section: Resultsmentioning

confidence: 64%

“…In the last years, there has been accumulating evidence suggesting that PS can reduce Aβ-mediated hippocampal neurodegeneration and memory impairments in rodents, inhibit Aβ-induced brain cell apoptosis, and cause reduction in Aβ plaques in the cerebral cortex [ 26 , 27 , 28 , 29 ]. In our previous animal experiments, we clearly showed that PS effectively stimulates the clearing function of the meningeal lymphatic vessels (MLVs), which play a crucial role in Aβ clearance [ 30 , 31 , 32 , 33 ]. We also demonstrated that the course of PS during 9 days effectively reduces the Aβ level in mice with AD [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…In our previous animal experiments, we clearly showed that PS effectively stimulates the clearing function of the meningeal lymphatic vessels (MLVs), which play a crucial role in Aβ clearance [ 30 , 31 , 32 , 33 ]. We also demonstrated that the course of PS during 9 days effectively reduces the Aβ level in mice with AD [ 33 , 34 ]. There is evidence that PS modulates the tone and permeability of the lymphatic vessels, probably through PS-induced stimulation of the synthesis of nitric oxide (NO) in the lymphatic endothelium [ 26 , 27 , 28 , 29 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Semyachkina-Glushkovskaya

Penzel

Blokhina

et al. 2021

Cells

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The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer’s disease (AD). Therefore, new strategies for the stimulation of Aβ clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including Aβ removal from the brain. There is increasing evidence that sleep plays an important role in Aβ clearance. Here, we tested our hypothesis that PS at night can stimulate Aβ clearance from the brain more effectively than PS during the day. Our results on healthy mice show that Aβ clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces Aβ accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing Aβ accumulation in the brain of people with disorder of Aβ metabolism, sleep deficit, elderly age, and jet lag.

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Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Semyachkina-Glushkovskaya

Penzel

Blokhina

et al. 2021

Cells

Self Cite

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“…Recently, a group of researchers from Russia have carried out a series of animal studies on the possible beneficial effects of PBM therapy on the lymphatic drainage function of the brain [ 15 , 16 , 59 , 84 , 85 , 86 , 87 ]. Their findings have opened up a new idea that PBM of the cranial and the extracranial lymphatics may be a promising approach for the treatment of brain disorders associated with CSF outflow abnormality [ 88 ].…”

Section: Pbm Therapymentioning

confidence: 99%

Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System

Salehpour

Khademi

Bragin

et al. 2022

IJMS

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The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system, devoted to drain away waste metabolic products and soluble proteins such as amyloid-beta. An impaired brain glymphatic system can increase the incidence of neurovascular, neuroinflammatory, and neurodegenerative diseases. Photobiomodulation (PBM) therapy can serve as a non-invasive neuroprotective strategy for maintaining and optimizing effective brain waste clearance. In this review, we discuss the crucial role of the glymphatic drainage system in removing toxins and waste metabolites from the brain. We review recent animal research on the neurotherapeutic benefits of PBM therapy on glymphatic drainage and clearance. We also highlight cellular mechanisms of PBM on the cerebral glymphatic system. Animal research has shed light on the beneficial effects of PBM on the cerebral drainage system through the clearance of amyloid-beta via meningeal lymphatic vessels. Finally, PBM-mediated increase in the blood–brain barrier permeability with a subsequent rise in Aβ clearance from PBM-induced relaxation of lymphatic vessels via a vasodilation process will be discussed. We conclude that PBM promotion of cranial and extracranial lymphatic system function might be a promising strategy for the treatment of brain diseases associated with cerebrospinal fluid outflow abnormality.

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Photobiomodulation improves functional recovery after mild traumatic brain injury

Stevens,

Hadis,

Thareja

et al. 2024

Bioengineering & Transla Med

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Mild traumatic brain injury (mTBI) is a common consequence of head injury but there are no recognized interventions to promote recovery of the brain. We previously showed that photobiomodulation (PBM) significantly reduced the number of apoptotic cells in adult rat hippocampal organotypic slice cultures. In this study, we first optimized PBM delivery parameters for use in mTBI, conducting cadaveric studies to calibrate 660 and 810 nm lasers for transcutaneous delivery of PBM to the cortical surface. We then used an in vivo weight drop mTBI model in adult rats and delivered daily optimized doses of 660, 810 nm, or combined 660/810 nm PBM. Functional recovery was assessed using novel object recognition (NOR) and beam balance tests, whilst histology and immunohistochemistry were used to assess the mTBI neuropathology. We found that PBM at 810, 660 nm, or 810/660 nm all significantly improved both NOR and beam balance performance, with 810 nm PBM having the greatest effects. Histology demonstrated no overt structural damage in the brain after mTBI, however, immunohistochemistry using brain sections showed significantly reduced activation of both CD11b+ microglia and glial fibrillary acidic protein (GFAP)+ astrocytes at 3 days post‐injury. Significantly reduced cortical localization of the apoptosis marker, cleaved caspase‐3, and modest reductions in extracellular matrix deposition after PBM treatment, limited to choroid plexus and periventricular areas were also observed. Our results demonstrate that 810 nm PBM optimally improved functional outcomes after mTBI, reduced markers associated with apoptosis and astrocyte/microglial activation, and thus may be useful as a potential regenerative therapy.

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Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain

Cited by 20 publications

References 10 publications

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System

Photobiomodulation improves functional recovery after mild traumatic brain injury

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