Transcranial sonography in idiopathic <scp>REM</scp> sleep behavior disorder and multiple system atrophy

Li, Xudong; Xue, Shifeng; Jia, Shaowei; Zhou, Zhi; Qiao, Yanan; Hou, Chunlei; Wei, Kun; Zheng, Wenjing; Rong, Pei; Jiao, Jinsong

doi:10.1111/pcn.12483

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…TCS can detect a hyperechogenicity of the SN in PD, while the lack of hyperechogenicity in the SN in other movement disorders is the basic principle underlying the ability of TCS to differentiate PD from other movement disorders. Besides, previous studies have shown that the basal ganglia may show hyperechogenicity of TCS in MSA [ 36 ]. In comparison, the lack of hyperechogenicity in the basal ganglia of patients with PD indicates that the SN findings combined with basal ganglia echogenicity can better distinguish patients with PD from those with other movement disorders, such as MSA.…”

Section: Discussionmentioning

confidence: 99%

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Mei

Yang

et al. 2021

Parkinson's Disease

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This meta-analysis aimed to evaluate the accuracy of hyperechogenicity of the substantia nigra (SN) for the differential diagnosis of Parkinson’s disease (PD) and other movement disorders. We systematically searched the PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure databases for relevant studies published between January 2015 and May 2020. Eligible articles comparing the echogenicity of the SN between patients with PD and those with other movement disorders were screened, and two independent reviewers extracted data according to the inclusion and exclusion criteria. Statistical analyses were conducted using STATA (version 15.0) (Stata Corporation, College Station, TX, USA), Review Manager 5.3 (Cochrane Collaboration), and Meta-DiSc1.4 to assess the pooled diagnostic value of transcranial sonography (TCS) for PD. Nine studies with a total of 1046 participants, including 669 patients with PD, were included in the final meta-analysis. Our meta-analysis demonstrated that hyperechogenicity of the SN had a pooled sensitivity and specificity of 0.85 (0.82, 0.87) and 0.71 (0.66, 0.75), respectively, for distinguishing idiopathic Parkinson’s disease from other movement disorders. Furthermore, the area under the curve of the summary receiver operating characteristic was 0.94. Transcranial sonography of the SN is a valuable tool for the differential diagnosis of PD and other movement disorders.

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Section: Discussionmentioning

confidence: 99%

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Mei

Yang

et al. 2021

Parkinson's Disease

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“…Because an important percentage of patients initially diagnosed with iRBD develop PD or other synucleopathies, this technique should be a useful tool to predict conversion of iRBD to PD and other neurodegenerative diseases. SNH was significantly more frequent in patients diagnosed with iRBD than in controls [ 21 , 48 , 49 , 50 ], although less frequent than in patients diagnosed with PD [ 48 , 51 ], and had a similar frequency than that reported in MSA patients [ 51 ]. SNH was more frequent in iRBD patients with than in those without mild motor abnormalities [ 24 ].…”

Section: Search Strategymentioning

confidence: 88%

Neurochemical Features of Rem Sleep Behaviour Disorder

Jiménez‐Jiménez

Alonso‐Navarro

García‐Martín

et al. 2021

JPM

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Dopaminergic deficiency, shown by many studies using functional neuroimaging with Single Photon Emission Computerized Tomography (SPECT) and Positron Emission Tomography (PET), is the most consistent neurochemical feature of rapid eye movement (REM) sleep behaviour disorder (RBD) and, together with transcranial ultrasonography, and determination of alpha-synuclein in certain tissues, should be considered as a reliable marker for the phenoconversion of idiopathic RBD (iRBD) to a synucleopathy (Parkinson’s disease –PD- or Lewy body dementia -LBD). The possible role in the pathogenesis of RBD of other neurotransmitters such as noradrenaline, acetylcholine, and excitatory and inhibitory neurotransmitters; hormones such as melatonin, and proinflammatory factors have also been suggested by recent reports. In general, brain perfusion and brain glucose metabolism studies have shown patterns resembling partially those of PD and LBD. Finally, the results of structural and functional MRI suggest the presence of structural changes in deep gray matter nuclei, cortical gray matter atrophy, and alterations in the functional connectivity within the basal ganglia, the cortico-striatal, and the cortico-cortical networks, but they should be considered as preliminary.

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“…Researchers also found hyperechogenicity in the basal ganglia in 50% (11 out of 22) of iRBD patients compared to 10% (2 out of 21) of controls (Li, Xue, et al, 2017). In another study, researchers reported on their investigation of echogenicity in the brainstem raphe nuclei in relation with depression in 72 iRBD patients (Vilas et al, 2015).…”

Section: Transcranial Sonographymentioning

confidence: 94%

“…Several authors reported substantia nigra hyperechogenicity in patients compared to controls (Iranzo et al, 2010;Iwanami et al, 2010;Shin et al, 2013;Stockner et al, 2009;Vilas et al, 2015), which was lower or of similar amplitude than in PD patients (Iwanami et al, 2010;Shin et al, 2013). The proportion of patients with pathological substantia nigra hyperechogenicity was higher in iRBD patients (32-63%) than in controls (5-29%) (Iranzo et al, 2010;Iwanami et al, 2010;Li, Xue, et al, 2017;Rupprecht et al, 2013;Shin et al, 2013;Stockner et al, 2009;Vilas et al, 2015).…”

Section: Transcranial Sonographymentioning

confidence: 99%

“…Researchers have conducted cross-sectional studies using transcranial sonography to estimate echogenicity of the substantia nigra in iRBD patients compared to controls (Iranzo et al, 2010;Iwanami, Miyamoto, Miyamoto, Hirata, & Takada, 2010;Li, Xue, et al, 2017;Shin, Joo, Kim, Dhong, & Cho, 2013;Stockner et al, 2009;Vilas et al, 2015). Several authors reported substantia nigra hyperechogenicity in patients compared to controls (Iranzo et al, 2010;Iwanami et al, 2010;Shin et al, 2013;Stockner et al, 2009;Vilas et al, 2015), which was lower or of similar amplitude than in PD patients (Iwanami et al, 2010;Shin et al, 2013).…”

Section: Transcranial Sonographymentioning

confidence: 99%

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Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder

Bourgouin

Rahayel

Gaubert

et al. 2019

International Review of Neurobiology

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Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by the loss of muscle atonia and the presence of undesirable motor manifestations during rapid eye movement sleep. Research findings have shown that iRBD is a prodromal stage of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. A wide array of neuroimaging techniques have improved our understanding of the prodromal stage of these diseases in patients with iRBD, and identified potential biomarkers. In this chapter, we summarize current knowledge about functional and structural central and peripheral neuroimaging in iRBD, including cross-sectional and longitudinal studies using positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging, and transcranial sonography. Current neuroimaging research has revealed several brain alterations in iRBD similar to those reported in synucleinopathies, thereby improving our understanding of the pathophysiology underlying the clinical presentation and progression of their prodromal stages. Moreover, some abnormalities detected by neuroimaging show promise as potential biomarkers to predict which individuals with iRBD may be at risk of conversion and therefore candidates for inclusion in future clinical trials of neuroprotection.

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Transcranial sonography in idiopathic REM sleep behavior disorder and multiple system atrophy

Cited by 12 publications

References 37 publications

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Neurochemical Features of Rem Sleep Behaviour Disorder

Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder

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