Transcranial sonography in Parkinson's disease

Bor-Seng-Shu, Edson; Pedroso, José Luiz; Andrade, Daniel Ciampi de; Barsottini, Orlando Graziani Póvoas; Andrade, Luiz Augusto Franco de; Barbosa, Egberto Reis; Teixeira, Manoel Jacobsen

doi:10.1590/s1679-45082012000200022

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…11,12 Transcranial Sonography in PD and Atypical Parkinsonian Syndromes Substantia nigra hyperechogenicity above the cutoff value as a typical finding in patients with PD ( Figure 1) was first described by Becker et al 1 Substantia nigra hyper echogenicity could be found unilaterally or asymmetrically bilaterally. This finding has been also shown by many other research groups over the last decades (for reviews, see Gaenslen and Berg 16 and Bor-Seng-Shu et al 17 ).…”

Section: A C Bsupporting

confidence: 79%

Transcranial Brain Parenchymal Sonography in Neurodegenerative and Psychiatric Diseases

Mijajlović

Tsivgoulis

Šternić

2014

J of Ultrasound Medicine

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Transcranial sonography is a highly sensitive noninvasive sonographic method for detection of early and specific echogenic changes in basal ganglia of patients with some neurodegenerative diseases. Transcranial sonography showed substantia nigra hyperechogenicity as a typical echo feature in idiopathic Parkinson disease and lenticular nucleus hyperechogenicity as a characteristic finding in atypical parkinsonian syndromes. Brain stem raphe hypoechogenicity or interruption has been shown to be highly prevalent in patients with unipolar depression as well as depression associated with certain neurodegenerative diseases. Transcranial sonography also revealed basal ganglia hyperechoic changes in movement disorders with trace metal accumulation such as Wilson disease, some entities of neurodegeneration with brain iron accumulation, as well as several forms of spinocerebellar ataxia. Transcranial sonography is a valuable neuro imaging method for early and differential diagnosis and follow-up of patients with neurodegenerative and psychiatric diseases.

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Section: A C Bsupporting

confidence: 79%

Transcranial Brain Parenchymal Sonography in Neurodegenerative and Psychiatric Diseases

Mijajlović

Tsivgoulis

Šternić

2014

J of Ultrasound Medicine

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“…Cerebral vasomotor reactivity (CVR) was evaluated by measuring the breath holding index (BHI) [ 33 ]. The hyperechogenic area at the SN was measured automatically by encircling the outer circumference of the area of hyperechogenicity, and the highest value was recorded [ 34 ]. Patients with at least one echogenic size ≥ 18 mm 2 were classified as hyperechogenic [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

George,

Roushdy,

Fathy

et al. 2024

BMC Neurol

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Background Parkinson’s disease (PD) and vascular parkinsonism (VaP) have highly overlapping phenotypes, and different prognosis. This study comprehensively investigated the clinical, brain MRI and transcranial sonography differences between VaP and PD. Methods Forty-eight patients with PD, 27 patients with VaP, and 29 healthy controls were compared. All patients were assessed using the MDS-UPDRS, Berg Balance Scale (BBS), Ten-Meter Walking Test (10-MWT), Time Up and Go Test, and Non-Motor Symptoms Scale. Beck Depression Inventory, PD questionnaire- 39, international urine incontinence scale, cognitive assessment scales, MRI brain and transcranial colour-coded doppler. The study was registered on clinical-Trial.gov (NCT04308135) on 03/12/2020. Results VaP patients showed significantly older age of onset, shorter disease duration, lower drug doses and levodopa responsiveness, higher On and Off axial scores, On and Off BBS, higher On scores for PIGD, rigidity, bradykinesia and total motor MDS-UPDRS, lower On and Off tremor, lower-half predominance, lower asymmetrical presentation and symmetric index than PD patients. VaP patients had worse non-motor symptoms Scale (NMSS) than controls except for perceptual problems/hallucinations but better symptoms than PD patients except for urinary dysfunction. Quality of life (QoL) was impaired in VaP patients and was correlated with motor function and NMSs. The VaP group had significantly higher white matter lesions and brain atrophy, with lower hyperechogenicity of the substantia nigra and more impaired cerebral vascular resistance and vasoreactivity than the PD group. Conclusions VaP has a characteristic motor and non-motor profile, with impaired QoL, white matter, and transcranial sonography abnormalities that differentiate it from PD. Further studies are warranted to explore the role of vascular lesions in the pathogenesis of VaP. Trial registration The registered identifier NCT04308135 on clinical-Trial.gov. Registered on 03/12/2020.

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“…Compared to controls, results showed that patients with tremulant form of PD had greater ALFF in the posterior cerebellum contralateral to the more affected side by tremor. 15 Enod= Nodal efficiency 16 Ndeg= Nodal degree 17 NBet= Nodal betweeness 18 Cp= Clustering coefficient 19 Lp= Path Lenght 20 Eloc= Local Efficiency Since PD is associated with a reduction of the motor activity, and based on the previous studies which, in its majority, pointed out to a decreased global efficiency, our hypothesis was more driven towards a diminished GE of the motor network in PD in comparison to controls.…”

Section: Pairwise Metrics Studies In Pdmentioning

confidence: 84%

Diminuição da conectividade funcional medida pela eficiência global da rede motora: estudo comparativo entre doença de Parkinson, tremor essencial e voluntários sadios

Pinto¹

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Background: Graph Theory (GT) is a mathematical field that analyzes complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's Disease (PD) and Essential Tremor (ET).Objectives: To evaluate the functional connectivity (FC) measured by the Global Efficiency (GE) of the motor network in PD and compare it to ET and Healthy Controls (HC), and correlate it to clinical parameters. Methods: 103 subjects (54PD, 18ET, 31HC) were submitted to structural and functional MRI. A network was designed with Regions of Interest (ROIs) involved in motor function and GT was applied to determine its GE. Clinical parameters were analyzed as covariates to estimate the impact of disease severity and medication on GE.

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Transcranial sonography in Parkinson's disease

Cited by 7 publications

References 34 publications

Transcranial Brain Parenchymal Sonography in Neurodegenerative and Psychiatric Diseases

Transcranial Brain Parenchymal Sonography in Neurodegenerative and Psychiatric Diseases

The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study

Diminuição da conectividade funcional medida pela eficiência global da rede motora: estudo comparativo entre doença de Parkinson, tremor essencial e voluntários sadios

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