Transcript Abundance Explains mRNA Mobility Data in <i>Arabidopsis thaliana</i>

Calderwood, Alexander; Kopriva, Stanislav; Morris, Richard J.

doi:10.1105/tpc.15.00956

Cited by 97 publications

(84 citation statements)

References 23 publications

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“…46 This is comparable to long-distance transport of mRNAs, which move from shootto-root in large numbers via the phloem, dependent predominantly on their abundance. 49 Whether movement of sRNAs is related to their abundance remains to be discovered. 46 we demonstrated the capacity of DCL-dependent mobile sRNAs originating in the shoots to regulate thousands of methylation loci in the roots.…”

Section: Srna Mobilitymentioning

confidence: 99%

Mobile small RNAs and their role in regulating cytosine methylation of DNA

Hardcastle

Lewsey

2016

RNA Biology

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Small (s)RNAs of 21 to 24 nucleotides are associated with RNA silencing and methylation of DNA cytosine residues. All sizes can move from cell-to-cell and long distance in plants, directing RNA silencing in destination cells. Twenty-four nucleotide sRNAs are the predominant long-distance mobile species. Thousands move from shoot to root, where they target methylation of transposable elements both directly and indirectly. We derive several classes of interaction between small RNAs and methylation and use these to explore the mechanisms of methylation and gene expression that associate with mobile sRNA signaling.

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Section: Srna Mobilitymentioning

confidence: 99%

Mobile small RNAs and their role in regulating cytosine methylation of DNA

Hardcastle

Lewsey

2016

RNA Biology

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“…Within each cell (green boxes), the random walk of mobile (blue; reaching the cell surface) and nonmobile (red) transcripts are shown for a given computational run of the model. (Reprinted from Calderwood et al [2016], Figure 1. …”

Section: Nancy R Hofmannmentioning

confidence: 99%

“…A new Breakthrough Report from Calderwood et al (2016) takes advantage of the availability of this large data set of mobile transcripts to test whether mRNA mobility can be explained by the abundance of that transcript in companion cells. The authors built a computational model in which individual mRNA molecules carry out a random walk through a box-shaped companion cell (see figure).…”

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confidence: 99%

Should I Stay or Should I Go? Abundance as a New Null Hypothesis for Determination of mRNA Mobility

Hofmann

2016

Plant Cell

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“…It is more likely that the high native sizeexclusion limit of PPUs is the key factor that determines whether a protein will, or will not, enter the translocation stream. In the case of CC proteins (Paultre et al, 2016) and mobile mRNAs (Calderwood et al, 2016), simple abundance and size may determine the likelihood of macromolecular movement from CC to SE, the size-exclusion limit of PPUs determining the upper molecular cutoff. Intriguingly, almost all the examples of native, phloemmobile macromolecules cited by Schulz (PP2, FT, and CmPP16) fit these criteria.…”

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confidence: 99%