Transcription and replication of rhabdoviruses.

Banerjee, Amiya K.

doi:10.1128/mmbr.51.1.66-87.1987

Cited by 187 publications

(119 citation statements)

References 165 publications

(239 reference statements)

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“…It would appear that there is a NP and P kinase(s) of cellular origin, which is tightly associated with NCs in virions, but which can also function independently of viral NCs in vivo . These results do not rule out that a fraction of the phosphorylation is due to the L protein, as suggested for the VSV P protein (Chattopadhyah and Banerjee, 1987) . If phosphorylation of the N-terminus of P modulates its activity as is widely believed, we would then expect that the activity of V would be similarly modulated .…”

Section: The Phosphorylation Of the V Proteinmentioning

confidence: 74%

“…The P and L proteins are also found as a complex, both on and off the NC core (Hamaguchi et al, 1983 ;Portner et at, 1988) . By analogy to the rhabdovirus VSV, whose L gene and that of the paramyxoviruses are thought to share a common ancestor (Poch et at, 1989), L is the actual polymerase, and capping and poly(A) formation of mRNAs are thought to map to this protein as well (Banerjee, 1987) . The VSV counterpart to the paramyxovirus P protein is NS, which has recently been referred to as P (Herman, 1986 ;Bilsel et at, 1990), as NS (nonstructural) is a misnomer .…”

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confidence: 99%

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Characterization of the Sendai virus V protein with an anti-peptide antiserum

et al. 1991

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The Sendai virus V protein, which is a fusion of the P and V ORFs of the P gene, was characterized with antisera to a portion of the V ORF and compared to the P protein. The only property found in common with P is that V is also highly phosphorylated, and this is so even when these proteins are expressed independently of the other viral proteins. Otherwise, V was not found in virions, was not strongly associated with viral nucleocapsids like P, and anti-V had no effect on viral RNA synthesis in vitro under conditions where anti-P was highly inhibitory. The available evidence suggests that V may play a role in RNA synthesis, but it is not an essential one like that of the P protein.

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Section: The Phosphorylation Of the V Proteinmentioning

confidence: 74%

mentioning

confidence: 99%

Characterization of the Sendai virus V protein with an anti-peptide antiserum

et al. 1991

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“…1a) or rabies. Similarities between CHPV and VSV in genetic makeup, polypeptide composition and life cycle lead to include CHPV within vesiculovirus genus (Banerjee 1987a).…”

Section: Chandipura Virus: a General Overviewmentioning

confidence: 99%

Reviewing Chandipura: A Vesiculovirus in Human Epidemics

et al. 2007

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Chandipura virus, a member of the rhabdoviridae family and vesiculovirus genera, has recently emerged as human pathogen that is associated with a number of outbreaks in different parts of India. Although, the virus closely resembles with the prototype vesiculovirus, Vesicular Stomatitis Virus, it could be readily distinguished by its ability to infect humans. Studies on Chandipura virus while shed light into distinct stages of viral infection; it may also allow us to identify potential drug targets for antiviral therapy. In this review, we have summarized our current understanding of Chandipura virus life cycle at the molecular detail with particular interest in viral RNA metabolisms, namely transcription, replication and packaging of viral RNA into nucleocapsid structure. Contemporary research on otherwise extensively studied family member Vesicular Stomatitis Virus has also been addressed to present a more comprehensive picture of vesiculovirus life cycle. Finally, we reveal examples of protein economy in Chandipura virus life-cycle whereby each viral protein has evolved complexity to perform multiple tasks.

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“…Involvement of N proteins in the transcription of helical RNA viruses is by no means limited to coronaviruses. N protein functions similarly during the transcription and replication of rhabdoviruses (Banerjee, 1987).…”

Section: Nproteinmentioning

confidence: 99%

A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination

Olsen

1993

Veterinary Microbiology

112

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Feline infectious peritonitis (FIP) has been an elusive and frustrating problem for veterinary practitioners and cat breeders for many years. Over the last several years, reports have begun to elucidate aspects of the molecular biology of the causal virus (FIPV). These papers complement a rapidly growing base of knowledge concerning the molecular organization and replication of coronaviruses in general. The fascinating immunopathogenesis of FIPV infection and the virus' interaction with macrophages has also been the subject of several recent papers. It is now clear that FIPV may be of interest to scientists other than veterinary virologists since its pathogenesis may provide a useful model system for other viruses whose infectivity is enhanced in the presence of virus-specific antibody. With these advances and the recent release of the first commercially-available FIPV vaccine, it is appropriate to review what is known about the organization and replication of coronaviruses and the pathogenesis of FIPV infection.

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Transcription and replication of rhabdoviruses.

Cited by 187 publications

References 165 publications

Characterization of the Sendai virus V protein with an anti-peptide antiserum

Characterization of the Sendai virus V protein with an anti-peptide antiserum

Reviewing Chandipura: A Vesiculovirus in Human Epidemics

A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination

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