Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

Abstract

Background: Cancer is the leading cause of death in the world. The mechanism is not fully elucidated and the therapeutic effect is also unsatisfactory. In our study, we aim to find new target gene in pan-cancer. Methods: Differently expressed genes (DEGs) was screened out in various types of cancers from GEO database. The expression of DEG (TCEAL2) in tumor cell lines, normal tissues and tumor tissues was calculated. Then the clinical characteristics, DNA methylation, tumor infiltration and gene enrichment of TCEAL2 was studied. Results: TCEAL2 expressions were down-regulated in most cancers. Its expression and methylation were positively or negatively associated with prognosis in different cancers. The tumor infiltration results revealed that TCEAL2 was significantly related with many immune cells especially NK cells and immune-related genes in majority cancers. Furthermore, tau protein and tubulin binding were involved in the molecular function mechanisms of TCEAL2. Conclusion: TCEAL2 may be a novel prognostic marker in different cancers and may affect tumor through immune infiltration.

TCEAL5 cooperates with the NuRD complex to epigenetically silence mesenchymal genes in glioma

“…TCEAL1 is associated with X-linked dominant neurodevelopmental syndromes and in uences neurological traits 4 . TCEAL2 has been highlighted as a prognostic marker in pan-cancer studies, indicating its signi cance in cancer biology 5 . TCEAL2 has also been reported to function as a tumor suppressor in renal cell carcinoma and to correlate with better patient prognosis 6 .…”