2015
DOI: 10.1186/1752-0509-9-s1-s5
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Transcription factor and microRNA-regulated network motifs for cancer and signal transduction networks

Abstract: BackgroundMolecular networks are the basis of biological processes. Such networks can be decomposed into smaller modules, also known as network motifs. These motifs show interesting dynamical behaviors, in which co-operativity effects between the motif components play a critical role in human diseases. We have developed a motif-searching algorithm, which is able to identify common motif types from the cancer networks and signal transduction networks (STNs). Some of the network motifs are interconnected which c… Show more

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Cited by 29 publications
(22 citation statements)
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“…The aberrations of TFs (e.g., AML1 and HOXs) and miRNAs (e.g., miR-150/17/ 19a/155) have been found to contribute to the disease progression of CML BC (12,13). Furthermore, TF and miRNA can regulate mutually and coregulate the same target to form feedback loop or feed-forward loop regulatory motifs (14), which are vital and common regulatory motifs in different biologic processes and diseases (14)(15)(16).…”
Section: Introductionmentioning
confidence: 99%
“…The aberrations of TFs (e.g., AML1 and HOXs) and miRNAs (e.g., miR-150/17/ 19a/155) have been found to contribute to the disease progression of CML BC (12,13). Furthermore, TF and miRNA can regulate mutually and coregulate the same target to form feedback loop or feed-forward loop regulatory motifs (14), which are vital and common regulatory motifs in different biologic processes and diseases (14)(15)(16).…”
Section: Introductionmentioning
confidence: 99%
“…2. FFL motifs are important loops in gene coregulatory networks and play critical roles in various biological processes such as cell differentiation, development, signal transduction, and diseases (Guzzi et al 2015;Zhang et al 2013;Hsieh et al 2015;Osella et al 2011).…”
Section: Resultsmentioning
confidence: 99%
“…It is tripartite co-regulatory motif of a Transcription Factor (TF), miRNA and gene in which a TF regulates a miRNA or a miRNA regulates a TF, and both jointly coregulates a target gene. This three node motifs are found significantly overexpressed in gene regulatory networks [17]. Identification of these motifs have been found helpful in predicting important targets for diagnosis, prognosis and therapeutics purpose in multifactorial disorders [18].…”
Section: Introductionmentioning
confidence: 93%