2019
DOI: 10.3390/genes10100802
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Transcription Factor CEBPB Inhibits the Expression of the Human HTR1A by Binding to 5′ Regulatory Region In Vitro

Abstract: This study identified a transcription factor that might bind to the 5′ regulatory region of the HTR1A and explored the potential effect on 5-HT1A receptor expression. Based on JASPAR predictions, the binding of the transcription factor was demonstrated using the electrophoretic mobility shift assay (EMSA). Vectors over-expressing the transcription factor were co-transfected into HEK-293 and SK-N-SH cells with the recombinant pGL3 vector, and relative fluorescence intensity was measured to determine regulatory … Show more

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Cited by 3 publications
(1 citation statement)
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“…In addition, neuroinflammation also contributes to lipopolysaccharide-induced depressive-like behavior in female and male rats with the involvement of glucocorticoid receptor and C/EBPβ ( Adzic et al, 2015 ). Moreover, C/EBPβ could strongly inhibit the level of the HTR1A gene (gene of 5-HT1A receptor) and resulted in the susceptibility to mental illness ( Liu et al, 2019 ). Besides neuroinflammation, HFD dysregulates glucose metabolism, causes chronic hyperglycemia and impairments of glucose tolerance, which eventually caused T2DM ( Dutheil et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, neuroinflammation also contributes to lipopolysaccharide-induced depressive-like behavior in female and male rats with the involvement of glucocorticoid receptor and C/EBPβ ( Adzic et al, 2015 ). Moreover, C/EBPβ could strongly inhibit the level of the HTR1A gene (gene of 5-HT1A receptor) and resulted in the susceptibility to mental illness ( Liu et al, 2019 ). Besides neuroinflammation, HFD dysregulates glucose metabolism, causes chronic hyperglycemia and impairments of glucose tolerance, which eventually caused T2DM ( Dutheil et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%