2023
DOI: 10.1155/2023/8210685
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Transcription Factor E2F1 Regulates the Expression of ADRB2

Abstract: Adrenergic beta-2-receptor (ADRB2) is highly expressed in various tissue cells, affecting the susceptibility, development, and drug efficacy of diseases such as bronchial asthma and malignant tumor. However, the transcriptional regulatory mechanism of the human ADRB2 gene remains unclear. This study aimed to clarify whether E2F transcription factor 1 (E2F1) was involved in the transcriptional regulation of the human ADRB2 gene. First, the 5′ flanking region of the human ADRB2 gene was cloned, and its activity … Show more

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