Transcription Factors and ncRNAs Associated with CYP3A Expression in Human Liver and Small Intestine Assessed with Weighted Gene Co-Expression Network Analysis

Huang, Hui-Na; Zhang, Siqi; Wen, Xiaozhen; Sadée, Wolfgang; Wang, Daqing; Yang, Siyao; Li, Liang

doi:10.3390/biomedicines10123061

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…It is well established that ncRNAs might act as regulators at different levels, including through modulation of the stability or translation rate of their target mRNAs (HUANG et al, 2022). In T. brucei, coding and ncRNA interactions were confirmed for Grumpy, a ncRNA involved in parasite differentiation (GUEGAN et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation inLeishmania braziliensis

Quilles,

Espada,

Orsine

et al. 2024

Preprint

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The protozoan parasiteLeishmaniaspp. is a causative agent of leishmaniasis, a disease that affects millions of people in more than 80 countries worldwide. Apart from its medical relevance, this organism has a genetic organization that is unique among eukaryotes. Studies of the mechanisms regulating gene expression in Leishmania led us to investigate noncoding RNAs (ncRNAs) as regulatory elements. We previously identified differentially expressed (DE) ncRNAs inLeishmania braziliensiswith potential roles in the parasite biology and development. Herein, we present a functional analysis of one such DE ncRNA, the 147-nucleotide-long transcript ncRNA97, which is preferentially expressed in amastigotes, the replicative form within mammalian phagocytes. By RT-qPCR the ncRNA97 was detected in greater quantities in the nucleus under physiological conditions and in the cytoplasm under nutritional stress. Interestingly, the transcript is protected at the 5' end but is not processed by the canonical trypanosomatid trans-splicing mechanism, according to the RNA circularization assay. ncRNA97 knockout (KO) and addback (AB) transfectants were generated and subjected to phenotypic analysis, which revealed that ncRNA97 impairs the starvation response and differentiation to the infective form. Comparative transcriptomics of ncRNA97KO and parental cells revealed that transcripts encoding amastigote-specific proteins were affected. This pioneering work demonstrates that ncRNAs contribute to the developmental regulatory mechanisms ofLeishmania.

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Section: Discussionmentioning

confidence: 99%

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation inLeishmania braziliensis

Quilles,

Espada,

Orsine

et al. 2024

Preprint

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show abstract

“… 57 Moreover, Wu et al found that LncRNA HNF4A-AS1 (hepatocyte nuclear factor 4 alpha antisense RNA 1) and AL109659.2 were highly expressed, and both significantly enhanced resistance to sorafenib. 58 …”

Section: Lncrna In Tumorigenesis and Chemotherapy Resistancementioning

confidence: 99%

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Zhang,

Wu,

Wang

et al. 2024

DDDT

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In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment. The abnormal expression of lncRNA is considered a contributing factor to the drug resistance. Furthermore, drug resistance may be influenced by genetic and epigenetic variations, as well as individual differences in patient treatment response, attributable to polymorphisms in metabolic enzyme genes. This review focuses on the mechanism of lncRNAs resistance to target drugs in the study of tumors with high mortality, aiming to establish a theoretical foundation for targeted therapy.

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Methyltransferase Like-3–Mediated N6-Methyladenosine Modification of Long Noncoding RNA Hepatocyte Nuclear Factor 1a Antisense RNA 1/Hepatocyte Nuclear Factor 4a Antisense RNA 1 Regulates Cytochrome P450 Enzyme Expression

Yu,

Wang,

Xiong

et al. 2024

Drug Metab Dispos

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Transcription Factors and ncRNAs Associated with CYP3A Expression in Human Liver and Small Intestine Assessed with Weighted Gene Co-Expression Network Analysis

Cited by 5 publications

References 46 publications

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation inLeishmania braziliensis

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation inLeishmania braziliensis

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Methyltransferase Like-3–Mediated N6-Methyladenosine Modification of Long Noncoding RNA Hepatocyte Nuclear Factor 1a Antisense RNA 1/Hepatocyte Nuclear Factor 4a Antisense RNA 1 Regulates Cytochrome P450 Enzyme Expression

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