Transcription factors in DNA replication

Fine mapping and functional activity of the adenosine deaminase origin in murine embryonic fibroblasts

“…JUND is the most broadly expressed member of the JUN family of transcription factors and in its absence primary murine fibroblasts undergo a p53‐dependent cell cycle arrest and premature senescence. The exact mechanism by which these transcription factors enhance DNA replication remains unknown, but may include recruitment of the DNA replication machinery through protein–protein interactions, modulation of chromatin structure, mediation of nuclear matrix attachment of the origins, or by regulating transcription, thereby affecting DNA replication (reviewed in [Murakami and Ito, 1999).…”

Epigenetic regulation affects gene amplification in Drosophila development

“…In mammals, many transcription factors are proto-oncogenes, including c-Jun, c-Myb, and c-Myc (20,73). Their oncogenicity is thought to be due to dysregulation of the transcription that they promote.…”

Kick-starting the cell cycle: From growth-factor stimulation to initiation of DNA replication

“…Indeed, some of these transcription factors may also play a direct role in initiating replication; for example, some replication origins in higher eukaryotes are located in promoter regions of genes such as c-myc, and replication near the c-myc promoter can indeed be induced in a model replication system ͑specifically, the negative supercoiling introduced by transcription induced the unwinding of the DNA duplex at the origin sequence͒. 15 Another intriguing observation is that the CDKactivating kinase, CAK, has been found to be a component of protein complexes involved in the basal transcription machinery and that CAK can phosphorylate RNA polymerase II; 16 thus, CAK can also provide a direct link between cell cycle control and transcription.…”