Abstract:Pervasive transcription of eukaryotic genomes requires intricate mechanisms to delineate boundaries for each transcriptional unit. How transcription is efficiently terminated before invading neighboring genes remains an open question. Here, after dissecting the cleavage and polyadenylation landscape using a hybrid approach, we observed thousands of bidirectional termination zones in the genome of Saccharomyces cerevisiae. These zones are ~120 bp wide and terminate transcription from both sense and antisense st… Show more
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